Mary Wilson
Well-known member
Published: 03 March 2023
https://doi.org/10.1093/infdis/jiad056
Luca Schifanella, Jodi Anderson, Garritt Wieking, Peter J Southern, Spinello Antinori, Massimo Galli, Mario Corbellino, Alessia Lai, Nichole Klatt, Timothy W Schacker,
Ashley T Haase
Abstract
Alveolar type II (ATII) pneumocytes as defenders of the alveolus are critical to repairing lung injury. We investigated the ATII reparative response in COVID-19 pneumonia, because the initial proliferation of ATII cells in this reparative process should provide large numbers of target cells to amplify SARS-CoV-2 virus production and cytopathological effects to compromise lung repair. We show that both infected and uninfected ATII cells succumb to tumor necrosis factor-α (TNF)-induced necroptosis, Bruton’s tyrosine kinase (BTK)-induced pyroptosis and a new PANoptotic hybrid form of inflammatory cell death mediated by a PANoptosomal latticework that generates distinctive COVID-19 pathologies in contiguous ATII cells. Identifying TNF and BTK as the initiators of programmed cell death and SARS-CoV-2 cytopathic effects provides a rationale for early antiviral treatment combined with inhibitors of TNF and BTK to preserve ATII cell populations, reduce programmed cell death and associated hyperinflammation, and restore functioning alveoli in COVID-19 pneumonia.
https://watermark.silverchair.com/j...BPptOs1t0edLQUeWm8Whv8l2VwL6HMxvhZIgpxFvI8wDS
https://doi.org/10.1093/infdis/jiad056
Luca Schifanella, Jodi Anderson, Garritt Wieking, Peter J Southern, Spinello Antinori, Massimo Galli, Mario Corbellino, Alessia Lai, Nichole Klatt, Timothy W Schacker,
Ashley T Haase
Abstract
Alveolar type II (ATII) pneumocytes as defenders of the alveolus are critical to repairing lung injury. We investigated the ATII reparative response in COVID-19 pneumonia, because the initial proliferation of ATII cells in this reparative process should provide large numbers of target cells to amplify SARS-CoV-2 virus production and cytopathological effects to compromise lung repair. We show that both infected and uninfected ATII cells succumb to tumor necrosis factor-α (TNF)-induced necroptosis, Bruton’s tyrosine kinase (BTK)-induced pyroptosis and a new PANoptotic hybrid form of inflammatory cell death mediated by a PANoptosomal latticework that generates distinctive COVID-19 pathologies in contiguous ATII cells. Identifying TNF and BTK as the initiators of programmed cell death and SARS-CoV-2 cytopathic effects provides a rationale for early antiviral treatment combined with inhibitors of TNF and BTK to preserve ATII cell populations, reduce programmed cell death and associated hyperinflammation, and restore functioning alveoli in COVID-19 pneumonia.
https://watermark.silverchair.com/j...BPptOs1t0edLQUeWm8Whv8l2VwL6HMxvhZIgpxFvI8wDS