tetano
Editor, Senior Moderator
Vaccines (Basel). 2018 Jul 3;6(3). pii: E39. doi: 10.3390/vaccines6030039.
[h=1]The Effects of Birth Year, Age and Sex on Hemagglutination Inhibition Antibody Responses to Influenza Vaccination.[/h] Plant EP[SUP]1[/SUP], Eick-Cost AA[SUP]2[/SUP], Ezzeldin H[SUP]3[/SUP], Sanchez JL[SUP]4[/SUP], Ye Z[SUP]5[/SUP], Cooper MJ[SUP]6[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] The first exposure to influenza is thought to impact subsequent immune responses later in life. The consequences of this can be seen during influenza epidemics and pandemics with differences in morbidity and mortality for different birth cohorts. There is a need for better understanding of how vaccine responses are affected by early exposures to influenza viruses. In this analysis of hemagglutination inhibition (HI) antibody responses in two cohorts of military personnel we noticed differences related to age, sex, prior vaccination, deployment and birth year. These data suggest that HI antibody production, in response to influenza vaccination, is affected by these factors. The magnitude of this antibody response is associated with, among other factors, the influenza strain that circulated following birth.
[h=4]KEYWORDS:[/h] IgG; hemagglutinin; humoral antibody; influenza; original antigenic sin; serum
PMID: 29970820 DOI: 10.3390/vaccines6030039
Free full text
[h=1]The Effects of Birth Year, Age and Sex on Hemagglutination Inhibition Antibody Responses to Influenza Vaccination.[/h] Plant EP[SUP]1[/SUP], Eick-Cost AA[SUP]2[/SUP], Ezzeldin H[SUP]3[/SUP], Sanchez JL[SUP]4[/SUP], Ye Z[SUP]5[/SUP], Cooper MJ[SUP]6[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] The first exposure to influenza is thought to impact subsequent immune responses later in life. The consequences of this can be seen during influenza epidemics and pandemics with differences in morbidity and mortality for different birth cohorts. There is a need for better understanding of how vaccine responses are affected by early exposures to influenza viruses. In this analysis of hemagglutination inhibition (HI) antibody responses in two cohorts of military personnel we noticed differences related to age, sex, prior vaccination, deployment and birth year. These data suggest that HI antibody production, in response to influenza vaccination, is affected by these factors. The magnitude of this antibody response is associated with, among other factors, the influenza strain that circulated following birth.
[h=4]KEYWORDS:[/h] IgG; hemagglutinin; humoral antibody; influenza; original antigenic sin; serum
PMID: 29970820 DOI: 10.3390/vaccines6030039
Free full text