tetano
Editor, Senior Moderator
Influenza Other Respi Viruses. 2012 Feb 21. doi: 10.1111/j.1750-2659.2012.00339.x. [Epub ahead of print]
The first cases of 2009 pandemic influenza A (H1N1) virus infection in the United States: a serologic investigation demonstrating early transmission.
Fry AM, Hancock K, Patel M, Gladden M, Doshi S, Blau DM, Sugerman D, Veguilla V, Lu X, Noland H, Bai Y, Maroufi A, Kao A, Kriner P, Lopez K, Ginsberg M, Jain S, Olsen SJ, Katz JM; for the Influenza Serology Working Group.
Source
Centers for Disease Control and Prevention, Atlanta, GA, USA Health and Human Services Agency, San Diego, CA, USA Imperial County Public Health Department, CA, USA.
Abstract
Please cite this paper as: Fry et al. (2012) The first cases of 2009 pandemic influenza A (H1N1) virus infection in the United States: a serologic investigation demonstrating early transmission. Influenza and Other Respiratory Viruses DOI: 10.1111/j.1750-2659.2012.00339.x. Background The first two laboratory-confirmed cases of 2009 pandemic influenza A (H1N1) virus (H1N1pdm09) infection were detected in San Diego (SD) and Imperial County (IC) in southern California, April 2009. Objectives To describe H1N1pdm09 infections and transmission early in the 2009 H1N1 pandemic. Patients/Methods We identified index case-patients from SD and IC with polymerase chain reaction (PCR)-confirmed H1N1pdm09 infections and investigated close contacts for a subset of case-patients from April 17-May 6, 2009. Acute and convalescent serum was collected. Serologic evidence for H1N1pdm09 infection was determined by microneutralization and hemagglutination inhibition assays. Results Among 75 close contacts of seven index case-patients, three reported illness onset prior to patient A or B, including two patient B contacts and a third with no links to patient A or B. Among the 69 close contacts with serum collected >14 days after the onset of index case symptoms, 23 (33%) were seropositive for H1N1pdm09, and 8 (35%) had no fever, cough, or sore throat. Among 15 household contacts, 8 (53%) were seropositive for H1N1pdm09. The proportion of contacts seropositive for H1N1pdm09 was highest in persons aged 5-24 years (50%) and lowest in persons aged ≥50 years (13%) (P = 0?07). Conclusions By the end of April 2009, before H1N1pdm09 was circulating widely in the community, a third of persons with close contact to confirmed H1N1pdm09 cases had H1N1pdm09 infection in SD and IC. Three unrelated clusters during March 21-30 suggest that transmission of H1N1pdm09 had begun earlier in southern California.
? 2012 Blackwell Publishing Ltd.
PMID:
22353441
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/22353441
The first cases of 2009 pandemic influenza A (H1N1) virus infection in the United States: a serologic investigation demonstrating early transmission.
Fry AM, Hancock K, Patel M, Gladden M, Doshi S, Blau DM, Sugerman D, Veguilla V, Lu X, Noland H, Bai Y, Maroufi A, Kao A, Kriner P, Lopez K, Ginsberg M, Jain S, Olsen SJ, Katz JM; for the Influenza Serology Working Group.
Source
Centers for Disease Control and Prevention, Atlanta, GA, USA Health and Human Services Agency, San Diego, CA, USA Imperial County Public Health Department, CA, USA.
Abstract
Please cite this paper as: Fry et al. (2012) The first cases of 2009 pandemic influenza A (H1N1) virus infection in the United States: a serologic investigation demonstrating early transmission. Influenza and Other Respiratory Viruses DOI: 10.1111/j.1750-2659.2012.00339.x. Background The first two laboratory-confirmed cases of 2009 pandemic influenza A (H1N1) virus (H1N1pdm09) infection were detected in San Diego (SD) and Imperial County (IC) in southern California, April 2009. Objectives To describe H1N1pdm09 infections and transmission early in the 2009 H1N1 pandemic. Patients/Methods We identified index case-patients from SD and IC with polymerase chain reaction (PCR)-confirmed H1N1pdm09 infections and investigated close contacts for a subset of case-patients from April 17-May 6, 2009. Acute and convalescent serum was collected. Serologic evidence for H1N1pdm09 infection was determined by microneutralization and hemagglutination inhibition assays. Results Among 75 close contacts of seven index case-patients, three reported illness onset prior to patient A or B, including two patient B contacts and a third with no links to patient A or B. Among the 69 close contacts with serum collected >14 days after the onset of index case symptoms, 23 (33%) were seropositive for H1N1pdm09, and 8 (35%) had no fever, cough, or sore throat. Among 15 household contacts, 8 (53%) were seropositive for H1N1pdm09. The proportion of contacts seropositive for H1N1pdm09 was highest in persons aged 5-24 years (50%) and lowest in persons aged ≥50 years (13%) (P = 0?07). Conclusions By the end of April 2009, before H1N1pdm09 was circulating widely in the community, a third of persons with close contact to confirmed H1N1pdm09 cases had H1N1pdm09 infection in SD and IC. Three unrelated clusters during March 21-30 suggest that transmission of H1N1pdm09 had begun earlier in southern California.
? 2012 Blackwell Publishing Ltd.
PMID:
22353441
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/22353441