tetano
Editor, Senior Moderator
PLoS One. 2015 Sep 14;10(9):e0137802. doi: 10.1371/journal.pone.0137802. eCollection 2015.
[h=1]The Functional Study of the N-Terminal Region of Influenza B Virus Nucleoprotein.[/h] Liu M[SUP]1[/SUP], Lam MK[SUP]1[/SUP], Zhang Q[SUP]2[/SUP], Elderfield R[SUP]3[/SUP], Barclay WS[SUP]3[/SUP], Shaw PC[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Influenza nucleoprotein (NP) is a major component of the ribonucleoprotein (vRNP) in influenza virus, which functions for the transcription and replication of viral genome. Compared to the nucleoprotein of influenza A (ANP), the N-terminal region of influenza B nucleoprotein (BNP) is much extended. By virus reconstitution, we found that the first 38 residues are essential for viral growth. We further illustrated the function of BNP by mini-genome reconstitution, fluorescence microscopy, electron microscopy, light scattering and gel shift. Results show that the N terminus is involved in the formation of both higher homo-oligomers of BNP and BNP-RNA complex.
PMID: 26368391 [PubMed - in process]
[h=1]The Functional Study of the N-Terminal Region of Influenza B Virus Nucleoprotein.[/h] Liu M[SUP]1[/SUP], Lam MK[SUP]1[/SUP], Zhang Q[SUP]2[/SUP], Elderfield R[SUP]3[/SUP], Barclay WS[SUP]3[/SUP], Shaw PC[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Influenza nucleoprotein (NP) is a major component of the ribonucleoprotein (vRNP) in influenza virus, which functions for the transcription and replication of viral genome. Compared to the nucleoprotein of influenza A (ANP), the N-terminal region of influenza B nucleoprotein (BNP) is much extended. By virus reconstitution, we found that the first 38 residues are essential for viral growth. We further illustrated the function of BNP by mini-genome reconstitution, fluorescence microscopy, electron microscopy, light scattering and gel shift. Results show that the N terminus is involved in the formation of both higher homo-oligomers of BNP and BNP-RNA complex.
PMID: 26368391 [PubMed - in process]