tetano
Editor, Senior Moderator
Genes Immun. 2017 Mar 23. doi: 10.1038/gene.2017.1. [Epub ahead of print]
[h=1]The immunogenetics of narcolepsy associated with A(H1N1)pdm09 vaccination (Pandemrix) supports a potent gene-environment interaction.[/h] Bomfim IL[SUP]1,[/SUP][SUP]2[/SUP], Lamb F[SUP]3[/SUP], Fink K[SUP]1,[/SUP][SUP]4[/SUP], Szak?cs A[SUP]5[/SUP], Silveira A[SUP]2,[/SUP][SUP]6[/SUP], Franz?n L[SUP]1,[/SUP][SUP]2[/SUP], Azhary V[SUP]1,[/SUP][SUP]2[/SUP], Maeurer M[SUP]7,[/SUP][SUP]8[/SUP], Feltelius N[SUP]9[/SUP], Darin N[SUP]10[/SUP], Hallb??k T[SUP]10[/SUP], Arnheim-Dahlstr?m L[SUP]3[/SUP], Kockum I[SUP]1,[/SUP][SUP]2[/SUP], Olsson T[SUP]1,[/SUP][SUP]2,[/SUP][SUP]4[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] The influenza A(H1N1)pdm09 vaccination campaign from 2009 to 2010 was associated with a sudden increase in the incidence of narcolepsy in several countries. Narcolepsy with cataplexy is strongly associated with the human leukocyte antigen (HLA) class II DQB1*06:02 allele, and protective associations with the DQB1*06:03 allele have been reported. Several non-HLA gene loci are also associated, such as common variants of the T-cell receptor-α (TRA), the purinergic receptor P2RY11, cathepsin H (CTSH) and TNFSF4/OX40L/CD252. In this retrospective multicenter study, we investigated if these predisposing gene loci were also involved in vaccination-associated narcolepsy. We compared HLA- along with single-nucleotide polymorphism genotypes for non-HLA regions between 42 Pandemrix-vaccinated narcolepsy cases and 1990 population-based controls. The class II gene loci associations supported previous findings. Nominal association (P-value<0.05) with TRA as well as suggestive (P-value<0.1) associations with P2RY11 and CTSH were found. These associations suggest a very strong gene-environment interaction, in which the influenza A(H1N1)pdm09 strain or Pandemrix vaccine can act as potent environmental triggers.Genes and Immunity advance online publication, 23 March 2017; doi:10.1038/gene.2017.1.
PMID: 28332559 DOI: 10.1038/gene.2017.1
[h=1]The immunogenetics of narcolepsy associated with A(H1N1)pdm09 vaccination (Pandemrix) supports a potent gene-environment interaction.[/h] Bomfim IL[SUP]1,[/SUP][SUP]2[/SUP], Lamb F[SUP]3[/SUP], Fink K[SUP]1,[/SUP][SUP]4[/SUP], Szak?cs A[SUP]5[/SUP], Silveira A[SUP]2,[/SUP][SUP]6[/SUP], Franz?n L[SUP]1,[/SUP][SUP]2[/SUP], Azhary V[SUP]1,[/SUP][SUP]2[/SUP], Maeurer M[SUP]7,[/SUP][SUP]8[/SUP], Feltelius N[SUP]9[/SUP], Darin N[SUP]10[/SUP], Hallb??k T[SUP]10[/SUP], Arnheim-Dahlstr?m L[SUP]3[/SUP], Kockum I[SUP]1,[/SUP][SUP]2[/SUP], Olsson T[SUP]1,[/SUP][SUP]2,[/SUP][SUP]4[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] The influenza A(H1N1)pdm09 vaccination campaign from 2009 to 2010 was associated with a sudden increase in the incidence of narcolepsy in several countries. Narcolepsy with cataplexy is strongly associated with the human leukocyte antigen (HLA) class II DQB1*06:02 allele, and protective associations with the DQB1*06:03 allele have been reported. Several non-HLA gene loci are also associated, such as common variants of the T-cell receptor-α (TRA), the purinergic receptor P2RY11, cathepsin H (CTSH) and TNFSF4/OX40L/CD252. In this retrospective multicenter study, we investigated if these predisposing gene loci were also involved in vaccination-associated narcolepsy. We compared HLA- along with single-nucleotide polymorphism genotypes for non-HLA regions between 42 Pandemrix-vaccinated narcolepsy cases and 1990 population-based controls. The class II gene loci associations supported previous findings. Nominal association (P-value<0.05) with TRA as well as suggestive (P-value<0.1) associations with P2RY11 and CTSH were found. These associations suggest a very strong gene-environment interaction, in which the influenza A(H1N1)pdm09 strain or Pandemrix vaccine can act as potent environmental triggers.Genes and Immunity advance online publication, 23 March 2017; doi:10.1038/gene.2017.1.
PMID: 28332559 DOI: 10.1038/gene.2017.1