tetano
Editor, Senior Moderator
Comp Immunol Microbiol Infect Dis. 2013 Jan 2. pii: S0147-9571(12)00133-6. doi: 10.1016/j.cimid.2012.12.001. [Epub ahead of print]
The pathobiology of two Indonesian H5N1 avian influenza viruses representing different clade 2.1 sublineages in chickens and ducks.
Wibawa H, Bingham J, Nuradji H, Lowther S, Payne J, Harper J, Wong F, Lunt R, Junaidi A, Middleton D, Meers J.
Source
Commonwealth Scientific and Industrial Research Organisation (CSIRO)-Australian Animal Health Laboratory, Geelong, Victoria, Australia; School of Veterinary Science, The University of Queensland, Gatton Campus, Gatton, Queensland, Australia; Disease Investigation Centre Wates, Yogyakarta, Indonesia.
Abstract
To determine the pathobiology of Indonesian H5N1 highly pathogenic avian influenza, two viruses representing clades 2.1.1 and 2.1.3 were inoculated into broiler chickens and Pekin ducks via the eyes, nostrils and oropharynx. In chickens, both viruses produced fulminant disease; tissue tropism was broad but predominantly endothelial and viral loads in tissues were high. Except for one case of meningoencephalitis, the infection in ducks was sub-clinical, leading only to seroconversion. In these ducks, virus and viral antigen occurred in lower amounts, mainly in the respiratory tract (airsac and sinuses), prior to day 7 after inoculation. During clinical disease, chickens shed high virus titres orally and cloacally. Ducks intermittently shed low virus titres from the oral route for up to 8 days post-inoculation. We discuss the significance of the data for understanding the pathogenesis and pathobiology of Indonesian H5N1 in chickens and ducks.
Crown Copyright ? 2012. Published by Elsevier Ltd. All rights reserved.
PMID:
23290928
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/23290928
The pathobiology of two Indonesian H5N1 avian influenza viruses representing different clade 2.1 sublineages in chickens and ducks.
Wibawa H, Bingham J, Nuradji H, Lowther S, Payne J, Harper J, Wong F, Lunt R, Junaidi A, Middleton D, Meers J.
Source
Commonwealth Scientific and Industrial Research Organisation (CSIRO)-Australian Animal Health Laboratory, Geelong, Victoria, Australia; School of Veterinary Science, The University of Queensland, Gatton Campus, Gatton, Queensland, Australia; Disease Investigation Centre Wates, Yogyakarta, Indonesia.
Abstract
To determine the pathobiology of Indonesian H5N1 highly pathogenic avian influenza, two viruses representing clades 2.1.1 and 2.1.3 were inoculated into broiler chickens and Pekin ducks via the eyes, nostrils and oropharynx. In chickens, both viruses produced fulminant disease; tissue tropism was broad but predominantly endothelial and viral loads in tissues were high. Except for one case of meningoencephalitis, the infection in ducks was sub-clinical, leading only to seroconversion. In these ducks, virus and viral antigen occurred in lower amounts, mainly in the respiratory tract (airsac and sinuses), prior to day 7 after inoculation. During clinical disease, chickens shed high virus titres orally and cloacally. Ducks intermittently shed low virus titres from the oral route for up to 8 days post-inoculation. We discuss the significance of the data for understanding the pathogenesis and pathobiology of Indonesian H5N1 in chickens and ducks.
Crown Copyright ? 2012. Published by Elsevier Ltd. All rights reserved.
PMID:
23290928
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/23290928