tetano
Editor, Senior Moderator
Intern Med. 2018;57(4):497-501. doi: 10.2169/internalmedicine.8854-17. Epub 2018 Feb 15.
[h=1]The Prophylactic Effect of Anti-influenza Agents for an Influenza Outbreak in a University Hospital.[/h] Hagihara M[SUP]1[/SUP], Kato Y[SUP]1[/SUP], Kurumiya A[SUP]1[/SUP], Takahashi T[SUP]1[/SUP], Sakata M[SUP]1[/SUP], Kato H[SUP]1[/SUP], Sakanashi D[SUP]1[/SUP], Yamada A[SUP]1[/SUP], Suematsu H[SUP]1[/SUP], Hirai J[SUP]1[/SUP], Nishiyama N[SUP]1[/SUP], Koizumi Y[SUP]1[/SUP], Yamagishi Y[SUP]1[/SUP], Mikamo H[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Objective From November 24 to December 9, 2013, an outbreak of the influenza (flu) A (H3) virus occurred in a tertiary-care university hospital (1,014 beds). We herein report the prophylactic effect of anti-flu agents for controlling the flu outbreak. Methods We administered pre- or post-exposure prophylaxis with anti-flu agents in flu outbreak. To test the effectiveness of prophylaxis in a flu outbreak, we used the posterior mean of the reproductive value during the pre- and post-intervention period. We also simulated the probability distribution of new flu cases. We performed an analysis to quantify the strength of the intervention effect. Results A total of 97 people were diagnosed with flu before the intervention, and 7 were diagnosed after the intervention. A molecular analysis of the flu virus revealed that this outbreak was due to the flu A (H3) virus. A total of 3,702 people received prophylaxis. There was a significant reduction in the reproductive value from 1.89 [95% confidence interval (CI), 1.59 to 2.24] to 0.65 (95% CI, 0.02 to 1.00) after the intervention (p<0.001). Conclusion Prophylaxis with anti-flu agents, along with prompt identification and isolation of infected individuals, was effective in reducing the impact of a flu outbreak in a hospital.
[h=4]KEYWORDS:[/h] influenza (flu); oseltamivir; outbreak; prophylaxis; zanamivir
PMID: 29445061 DOI: 10.2169/internalmedicine.8854-17
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[h=1]The Prophylactic Effect of Anti-influenza Agents for an Influenza Outbreak in a University Hospital.[/h] Hagihara M[SUP]1[/SUP], Kato Y[SUP]1[/SUP], Kurumiya A[SUP]1[/SUP], Takahashi T[SUP]1[/SUP], Sakata M[SUP]1[/SUP], Kato H[SUP]1[/SUP], Sakanashi D[SUP]1[/SUP], Yamada A[SUP]1[/SUP], Suematsu H[SUP]1[/SUP], Hirai J[SUP]1[/SUP], Nishiyama N[SUP]1[/SUP], Koizumi Y[SUP]1[/SUP], Yamagishi Y[SUP]1[/SUP], Mikamo H[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Objective From November 24 to December 9, 2013, an outbreak of the influenza (flu) A (H3) virus occurred in a tertiary-care university hospital (1,014 beds). We herein report the prophylactic effect of anti-flu agents for controlling the flu outbreak. Methods We administered pre- or post-exposure prophylaxis with anti-flu agents in flu outbreak. To test the effectiveness of prophylaxis in a flu outbreak, we used the posterior mean of the reproductive value during the pre- and post-intervention period. We also simulated the probability distribution of new flu cases. We performed an analysis to quantify the strength of the intervention effect. Results A total of 97 people were diagnosed with flu before the intervention, and 7 were diagnosed after the intervention. A molecular analysis of the flu virus revealed that this outbreak was due to the flu A (H3) virus. A total of 3,702 people received prophylaxis. There was a significant reduction in the reproductive value from 1.89 [95% confidence interval (CI), 1.59 to 2.24] to 0.65 (95% CI, 0.02 to 1.00) after the intervention (p<0.001). Conclusion Prophylaxis with anti-flu agents, along with prompt identification and isolation of infected individuals, was effective in reducing the impact of a flu outbreak in a hospital.
[h=4]KEYWORDS:[/h] influenza (flu); oseltamivir; outbreak; prophylaxis; zanamivir
PMID: 29445061 DOI: 10.2169/internalmedicine.8854-17
Free full text