tetano
Editor, Senior Moderator
Ann Epidemiol. 2019 Jul 31. pii: S1047-2797(19)30040-7. doi: 10.1016/j.annepidem.2019.07.013. [Epub ahead of print]
[h=1]The respiratory microbiota: associations with influenza symptomatology and viral shedding.[/h] Lee KH[SUP]1[/SUP], Foxman B[SUP]2[/SUP], Kuan G[SUP]3[/SUP], L?pez R[SUP]4[/SUP], Shedden K[SUP]5[/SUP], Ng S[SUP]6[/SUP], Balmaseda A[SUP]7[/SUP], Gordon A[SUP]8[/SUP].
[h=3]Author information[/h] 1 Center for Molecular and Clinical Epidemiology of Infectious Diseases, Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor; Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD. 2 Center for Molecular and Clinical Epidemiology of Infectious Diseases, Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor. 3 Centro de Salud S?crates Flores Vivas, Ministry of Health, Managua, Nicaragua; Sustainable Sciences Institute, Managua, Nicaragua. 4 National Virology Laboratory, Centro Nacional de Diagn?stico y Referencia, Ministry of Health, Managua, Nicaragua. 5 Department of Statistics, University of Michigan, Ann Arbor; Department of Biostatistics, School of Public Health, University of Michigan, Ann Arbor. 6 Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor. 7 Sustainable Sciences Institute, Managua, Nicaragua; National Virology Laboratory, Centro Nacional de Diagn?stico y Referencia, Ministry of Health, Managua, Nicaragua. 8 Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor. Electronic address: gordonal@umich.edu.
[h=3]Abstract[/h] [h=4]PURPOSE:[/h] Manifestations of infection and the degree of influenza virus vary. We hypothesized that the nose/throat microbiota modifies the duration of influenza symptoms and viral shedding. Exploring these relationships may help identify additional methods for reducing influenza severity and transmission.
[h=4]METHODS:[/h] Using a household transmission study in Nicaragua, we identified secondary cases of influenza virus infection, defined as contacts with detectable virus or a greater than 4-fold change in hemagglutinin inhibition antibody titer. We characterized the nose/throat microbiota of secondary cases before infection and explored whether the duration of symptoms and shedding differed by bacterial community characteristics.
[h=4]RESULTS:[/h] Among 124 secondary cases of influenza, higher bacterial community diversity before infection was associated with longer shedding duration (Shannon acceleration factor [AF]: 1.61, 95% confidence interval [CI]: 1.24, 2.10) and earlier time to infection (Shannon AF: 0.72, 95% CI: 0.53, 0.97; Chao1 AF: 0.992, 95% CI: 0.986, 0.998). Neisseria and multiple other oligotypes were significantly associated with symptom and shedding durations and time to infection.
[h=4]CONCLUSIONS:[/h] The nose/throat microbiota before influenza virus infection was associated with influenza symptoms and shedding durations. Further studies are needed to determine if the nose/throat microbiota is a viable target for reducing influenza symptoms and transmission.
Copyright ? 2019 Elsevier Inc. All rights reserved.
[h=4]KEYWORDS:[/h] Influenza; Microbiota; Signs and symptoms; Virus shedding
PMID: 31451313 DOI: 10.1016/j.annepidem.2019.07.013
[h=1]The respiratory microbiota: associations with influenza symptomatology and viral shedding.[/h] Lee KH[SUP]1[/SUP], Foxman B[SUP]2[/SUP], Kuan G[SUP]3[/SUP], L?pez R[SUP]4[/SUP], Shedden K[SUP]5[/SUP], Ng S[SUP]6[/SUP], Balmaseda A[SUP]7[/SUP], Gordon A[SUP]8[/SUP].
[h=3]Author information[/h] 1 Center for Molecular and Clinical Epidemiology of Infectious Diseases, Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor; Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD. 2 Center for Molecular and Clinical Epidemiology of Infectious Diseases, Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor. 3 Centro de Salud S?crates Flores Vivas, Ministry of Health, Managua, Nicaragua; Sustainable Sciences Institute, Managua, Nicaragua. 4 National Virology Laboratory, Centro Nacional de Diagn?stico y Referencia, Ministry of Health, Managua, Nicaragua. 5 Department of Statistics, University of Michigan, Ann Arbor; Department of Biostatistics, School of Public Health, University of Michigan, Ann Arbor. 6 Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor. 7 Sustainable Sciences Institute, Managua, Nicaragua; National Virology Laboratory, Centro Nacional de Diagn?stico y Referencia, Ministry of Health, Managua, Nicaragua. 8 Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor. Electronic address: gordonal@umich.edu.
[h=3]Abstract[/h] [h=4]PURPOSE:[/h] Manifestations of infection and the degree of influenza virus vary. We hypothesized that the nose/throat microbiota modifies the duration of influenza symptoms and viral shedding. Exploring these relationships may help identify additional methods for reducing influenza severity and transmission.
[h=4]METHODS:[/h] Using a household transmission study in Nicaragua, we identified secondary cases of influenza virus infection, defined as contacts with detectable virus or a greater than 4-fold change in hemagglutinin inhibition antibody titer. We characterized the nose/throat microbiota of secondary cases before infection and explored whether the duration of symptoms and shedding differed by bacterial community characteristics.
[h=4]RESULTS:[/h] Among 124 secondary cases of influenza, higher bacterial community diversity before infection was associated with longer shedding duration (Shannon acceleration factor [AF]: 1.61, 95% confidence interval [CI]: 1.24, 2.10) and earlier time to infection (Shannon AF: 0.72, 95% CI: 0.53, 0.97; Chao1 AF: 0.992, 95% CI: 0.986, 0.998). Neisseria and multiple other oligotypes were significantly associated with symptom and shedding durations and time to infection.
[h=4]CONCLUSIONS:[/h] The nose/throat microbiota before influenza virus infection was associated with influenza symptoms and shedding durations. Further studies are needed to determine if the nose/throat microbiota is a viable target for reducing influenza symptoms and transmission.
Copyright ? 2019 Elsevier Inc. All rights reserved.
[h=4]KEYWORDS:[/h] Influenza; Microbiota; Signs and symptoms; Virus shedding
PMID: 31451313 DOI: 10.1016/j.annepidem.2019.07.013