tetano
Editor, Senior Moderator
Virus Res. 2012 Dec 10. pii: S0168-1702(12)00466-2. doi: 10.1016/j.virusres.2012.12.004. [Epub ahead of print]
The Role of MyD88 Signaling in Heterosubtypic Influenza A Virus Infections.
Madera RF, Libraty DH.
Source
Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, MA, USA.
Abstract
A mouse model of heterosubtypic influenza A virus infections was used to determine the role of MyD88 signaling in CD4+ T-cell, CD8+ T-cell, and IgG immune responses. We found that MyD88 signaling played an important role in anti-influenza A virus heterosubtypic lung and spleen CD4+ T-cell, and spleen CD8+ T-cell, immune responses. MyD88 dependent signaling was important for T-helper 1 cytokine production in anti-influenza A virus lung and spleen heterosubtypic CD4+ T-cells, but not for their frequencies. Toll-like receptor 7 dependent signaling played a partial role in anti-influenza A virus lung heterosubtypic CD4+ T-helper 1 responses and anti-influenza A virus heterosubtypic IgG2c antibody levels. Our results have important implications for the generation of effective universal influenza vaccines.
Copyright ? 2012. Published by Elsevier B.V.
PMID:
23238076
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/23238076
The Role of MyD88 Signaling in Heterosubtypic Influenza A Virus Infections.
Madera RF, Libraty DH.
Source
Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, MA, USA.
Abstract
A mouse model of heterosubtypic influenza A virus infections was used to determine the role of MyD88 signaling in CD4+ T-cell, CD8+ T-cell, and IgG immune responses. We found that MyD88 signaling played an important role in anti-influenza A virus heterosubtypic lung and spleen CD4+ T-cell, and spleen CD8+ T-cell, immune responses. MyD88 dependent signaling was important for T-helper 1 cytokine production in anti-influenza A virus lung and spleen heterosubtypic CD4+ T-cells, but not for their frequencies. Toll-like receptor 7 dependent signaling played a partial role in anti-influenza A virus lung heterosubtypic CD4+ T-helper 1 responses and anti-influenza A virus heterosubtypic IgG2c antibody levels. Our results have important implications for the generation of effective universal influenza vaccines.
Copyright ? 2012. Published by Elsevier B.V.
PMID:
23238076
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/23238076