tetano
Editor, Senior Moderator
Ther Adv Chronic Dis
. 2021 Mar 19;12:2040622321998860.
doi: 10.1177/2040622321998860. eCollection 2021.
Outcomes of coronavirus 2019 infection in patients with chronic kidney disease: a systematic review and meta-analysis
Yi-Chih Lin[SUP] 1 [/SUP], Tai-Shuan Lai[SUP] 2 [/SUP], Shuei-Liong Lin[SUP] 3 [/SUP], Yung-Ming Chen[SUP] 3 [/SUP], Tzong-Shinn Chu[SUP] 3 [/SUP], Yu-Kang Tu[SUP] 4 [/SUP]
Affiliations
Abstract
Background: Information on coronavirus disease 2019 (COVID-19) infection in patients with chronic kidney disease (CKD) remains limited. To understand the influence of COVID-19 infection in patients with pre-existing CKD, we conducted a systematic review and meta-analysis to evaluate and compare the risks of all-cause mortality, hospitalization, and critical progression between patients with and without CKD.
Methods: We selected randomized controlled trials (RCTs), prospective or retrospective observational, case-control, cross-sectional, and case-series studies analyzing outcomes of COVID-19 infection in patients with pre-existing CKD from the PubMed, Embase, and Cochrane Central Register of Controlled Trials databases published on the Internet before 16 July 2020.
Results: A total of 27 studies comprising 77,856 patients with COVID-19 infection was identified; 3922 patients with pre-existing CKD were assigned CKD group, and 73,934 patients were assigned to the non-CKD group. The pooled analysis showed that patients with CKD had a significantly higher risk of all-cause mortality and hospitalization than those without CKD [odds ratio (OR) 2.25, 95% confidence interval (CI) 1.91-2.66, p < 0.001; OR 4.29, 95% CI 2.93-6.28, p < 0.001; respectively]. Patients with CKD had a higher risk of critically ill conditions than those without CKD in the pooled analysis of studies with multivariable adjustment (adjusted OR 2.12, 95% CI 0.95-4.77, p = 0.07) and in the analysis of all included studies (OR 1.27, 95% CI 0.71-2.26, p = 0.41), but both analyses did not attain statistical significance.
Conclusion: COVID-19 infected patients with CKD had significantly increased risks of all-cause mortality and hospitalization compared with those without CKD.
Keywords: COVID-19; chronic kidney disease; hospitalization; meta-analysis; mortality.
. 2021 Mar 19;12:2040622321998860.
doi: 10.1177/2040622321998860. eCollection 2021.
Outcomes of coronavirus 2019 infection in patients with chronic kidney disease: a systematic review and meta-analysis
Yi-Chih Lin[SUP] 1 [/SUP], Tai-Shuan Lai[SUP] 2 [/SUP], Shuei-Liong Lin[SUP] 3 [/SUP], Yung-Ming Chen[SUP] 3 [/SUP], Tzong-Shinn Chu[SUP] 3 [/SUP], Yu-Kang Tu[SUP] 4 [/SUP]
Affiliations
- PMID: 33796245
- PMCID: PMC7985947
- DOI: 10.1177/2040622321998860
Abstract
Background: Information on coronavirus disease 2019 (COVID-19) infection in patients with chronic kidney disease (CKD) remains limited. To understand the influence of COVID-19 infection in patients with pre-existing CKD, we conducted a systematic review and meta-analysis to evaluate and compare the risks of all-cause mortality, hospitalization, and critical progression between patients with and without CKD.
Methods: We selected randomized controlled trials (RCTs), prospective or retrospective observational, case-control, cross-sectional, and case-series studies analyzing outcomes of COVID-19 infection in patients with pre-existing CKD from the PubMed, Embase, and Cochrane Central Register of Controlled Trials databases published on the Internet before 16 July 2020.
Results: A total of 27 studies comprising 77,856 patients with COVID-19 infection was identified; 3922 patients with pre-existing CKD were assigned CKD group, and 73,934 patients were assigned to the non-CKD group. The pooled analysis showed that patients with CKD had a significantly higher risk of all-cause mortality and hospitalization than those without CKD [odds ratio (OR) 2.25, 95% confidence interval (CI) 1.91-2.66, p < 0.001; OR 4.29, 95% CI 2.93-6.28, p < 0.001; respectively]. Patients with CKD had a higher risk of critically ill conditions than those without CKD in the pooled analysis of studies with multivariable adjustment (adjusted OR 2.12, 95% CI 0.95-4.77, p = 0.07) and in the analysis of all included studies (OR 1.27, 95% CI 0.71-2.26, p = 0.41), but both analyses did not attain statistical significance.
Conclusion: COVID-19 infected patients with CKD had significantly increased risks of all-cause mortality and hospitalization compared with those without CKD.
Keywords: COVID-19; chronic kidney disease; hospitalization; meta-analysis; mortality.