tetano
Editor, Senior Moderator
Thromb Haemost
. 2022 Mar 4.
doi: 10.1055/a-1788-7592. Online ahead of print.
THE ADA (AGE-D-DIMER-ALBUMIN) SCORE TO PREDICT THROMBOSIS IN SARS-CoV-2
Francesco Violi[SUP] 1 [/SUP], Pasquale Pignatelli[SUP] 2 [/SUP], Annarita Vestri[SUP] 3 [/SUP], Alessandra Spagnoli[SUP] 4 [/SUP], Francesco Cipollone[SUP] 5 [/SUP], Giancarlo Ceccarelli[SUP] 6 [/SUP], Alessandra Oliva[SUP] 6 [/SUP], Maria Amitrano[SUP] 7 [/SUP], Matteo Pirro[SUP] 8 [/SUP], Gloria Taliani[SUP] 6 [/SUP], Roberto Cangemi[SUP] 6 [/SUP], Miriam Lichtner[SUP] 9 [/SUP], Francesco Pugliese[SUP] 10 [/SUP], Marco Falcone[SUP] 11 [/SUP], Mario Venditti[SUP] 10 [/SUP], Claudio Maria Mastroianni[SUP] 10 [/SUP], Lorenzo Loffredo[SUP] 12 [/SUP]
Affiliations
Abstract
Background: Severe acute respiratory syndrome coronavirus-2 (SARS-CoV2)-related pneumonia is associated with venous and arterial thrombosis . Aim of the study was to find-out a new score for predicting thrombosis in patients with SARS-CoV-2.
Methods: We included a cohort of 674 patients affected by SARS-CoV-2, not requiring intensive care units, and followed-up during the hospitalization until discharge. Routinary analyses performed at in-hospital admission included also serum albumin and D-dimer while arterial and venous thromboses were the end-points of the study.
Results: During the follow-up thrombotic events 110 were registered; patients with thrombotic events were older and had lower albumin and higher D-dimer, compared to thrombotic event-free ones. On multivariable logistic regression with step by stepwise procedure age, serum albumin, D-dimer, were independently associated with thrombotic events. The linear combination of age, D-dimer, albumin allowed to build-up the ADA score, whose AUC was 0.752 (95% CI, 0.708-0.795). ADA score was internally validated by bootstrap sampling procedure giving an AUC of 0.752 (95% CI: 0.708 - 0.794).
Conclusions: Combination of age, D-dimer, albumin in the ADA score allows identifying SARS-CoV-2 patients at higher risk of thrombotic events.
. 2022 Mar 4.
doi: 10.1055/a-1788-7592. Online ahead of print.
THE ADA (AGE-D-DIMER-ALBUMIN) SCORE TO PREDICT THROMBOSIS IN SARS-CoV-2
Francesco Violi[SUP] 1 [/SUP], Pasquale Pignatelli[SUP] 2 [/SUP], Annarita Vestri[SUP] 3 [/SUP], Alessandra Spagnoli[SUP] 4 [/SUP], Francesco Cipollone[SUP] 5 [/SUP], Giancarlo Ceccarelli[SUP] 6 [/SUP], Alessandra Oliva[SUP] 6 [/SUP], Maria Amitrano[SUP] 7 [/SUP], Matteo Pirro[SUP] 8 [/SUP], Gloria Taliani[SUP] 6 [/SUP], Roberto Cangemi[SUP] 6 [/SUP], Miriam Lichtner[SUP] 9 [/SUP], Francesco Pugliese[SUP] 10 [/SUP], Marco Falcone[SUP] 11 [/SUP], Mario Venditti[SUP] 10 [/SUP], Claudio Maria Mastroianni[SUP] 10 [/SUP], Lorenzo Loffredo[SUP] 12 [/SUP]
Affiliations
- PMID: 35253143
- DOI: 10.1055/a-1788-7592
Abstract
Background: Severe acute respiratory syndrome coronavirus-2 (SARS-CoV2)-related pneumonia is associated with venous and arterial thrombosis . Aim of the study was to find-out a new score for predicting thrombosis in patients with SARS-CoV-2.
Methods: We included a cohort of 674 patients affected by SARS-CoV-2, not requiring intensive care units, and followed-up during the hospitalization until discharge. Routinary analyses performed at in-hospital admission included also serum albumin and D-dimer while arterial and venous thromboses were the end-points of the study.
Results: During the follow-up thrombotic events 110 were registered; patients with thrombotic events were older and had lower albumin and higher D-dimer, compared to thrombotic event-free ones. On multivariable logistic regression with step by stepwise procedure age, serum albumin, D-dimer, were independently associated with thrombotic events. The linear combination of age, D-dimer, albumin allowed to build-up the ADA score, whose AUC was 0.752 (95% CI, 0.708-0.795). ADA score was internally validated by bootstrap sampling procedure giving an AUC of 0.752 (95% CI: 0.708 - 0.794).
Conclusions: Combination of age, D-dimer, albumin in the ADA score allows identifying SARS-CoV-2 patients at higher risk of thrombotic events.