tetano
Editor, Senior Moderator
Trans R Soc Trop Med Hyg
. 2022 May 22;trac046.
doi: 10.1093/trstmh/trac046. Online ahead of print.
Critically ill COVID-19 patients in northeast Brazil: mortality predictors during the first and second waves including SAPS 3
Ana Paula Pires Lázaro[SUP] 1 2 [/SUP], Polianna Lemos Moura Moreira Albuquerque[SUP] 1 3 [/SUP], Gdayllon Cavalcante Meneses[SUP] 4 [/SUP], Marza de Sousa Zaranza[SUP] 3 4 [/SUP], Ana Beatriz Batista[SUP] 3 [/SUP], Natalia Linhares Ponte Aragão[SUP] 3 [/SUP], Andrea Mazza Beliero[SUP] 3 [/SUP], Álvaro Rolim Guimarães[SUP] 5 [/SUP], Nilcyeli Linhares Aragão[SUP] 4 [/SUP], Alessandra Marjorye Maia Leitão[SUP] 1 [/SUP], Marcelo Costa Freire de Carvalho[SUP] 1 [/SUP], Maria Isabel de Alencar Cavalcante[SUP] 1 [/SUP], Fabio Augusto Xerez Mota[SUP] 1 [/SUP], Elizabeth De Francesco Daher[SUP] 4 [/SUP], Alice Maria Costa Martins[SUP] 6 [/SUP], Geraldo Bezerra da Silva Junior[SUP] 1 2 7 [/SUP]
Affiliations
Abstract
Background: The Simplified Acute Physiology Score (SAPS) 3 is a reliable score to predict mortality. This study aims to investigate the predictive values of SAPS 3 and other clinical parameters for death in critically ill coronavirus disease 2019 (COVID-19) patients.
Methods: This is a prospective study in a tertiary hospital for patients who required intensive care due to COVID-19 infection in northeast Brazil. Two distinct groups were constructed according to the epidemiological data: first wave and second wave. The severity of patients admitted was estimated using the SAPS 3 score.
Results: A total of 767 patients were included: 290 were enrolled in the first wave and 477 in the second wave. Patients in the first wave had more comorbidities, were put on mechanical ventilation and required dialysis and vasopressors more frequently (p<0.05). During the second wave, non-invasive ventilation was more often required (p<0.05). In both periods, older patients and higher SAPS 3 scores on admission were associated with death (p<0.05). Non-invasive ventilation use showed a negative association with death only in the second wave period. In the first wave, the SAPS 3 score was more useful (area under the curve [AUC] 0.897) in predicting death in critically ill COVID-19 patients than in the second wave (AUC 0.810).
Conclusion: The SAPS 3 showed very reliable predictive values for death during the waves of the COVID-19 pandemic, mostly together with kidney and pulmonary dysfunction.
Keywords: COVID-19; SARS-CoV-2; Simplified Acute Physiology Score; intensive care units; mortality.
. 2022 May 22;trac046.
doi: 10.1093/trstmh/trac046. Online ahead of print.
Critically ill COVID-19 patients in northeast Brazil: mortality predictors during the first and second waves including SAPS 3
Ana Paula Pires Lázaro[SUP] 1 2 [/SUP], Polianna Lemos Moura Moreira Albuquerque[SUP] 1 3 [/SUP], Gdayllon Cavalcante Meneses[SUP] 4 [/SUP], Marza de Sousa Zaranza[SUP] 3 4 [/SUP], Ana Beatriz Batista[SUP] 3 [/SUP], Natalia Linhares Ponte Aragão[SUP] 3 [/SUP], Andrea Mazza Beliero[SUP] 3 [/SUP], Álvaro Rolim Guimarães[SUP] 5 [/SUP], Nilcyeli Linhares Aragão[SUP] 4 [/SUP], Alessandra Marjorye Maia Leitão[SUP] 1 [/SUP], Marcelo Costa Freire de Carvalho[SUP] 1 [/SUP], Maria Isabel de Alencar Cavalcante[SUP] 1 [/SUP], Fabio Augusto Xerez Mota[SUP] 1 [/SUP], Elizabeth De Francesco Daher[SUP] 4 [/SUP], Alice Maria Costa Martins[SUP] 6 [/SUP], Geraldo Bezerra da Silva Junior[SUP] 1 2 7 [/SUP]
Affiliations
- PMID: 35598042
- DOI: 10.1093/trstmh/trac046
Abstract
Background: The Simplified Acute Physiology Score (SAPS) 3 is a reliable score to predict mortality. This study aims to investigate the predictive values of SAPS 3 and other clinical parameters for death in critically ill coronavirus disease 2019 (COVID-19) patients.
Methods: This is a prospective study in a tertiary hospital for patients who required intensive care due to COVID-19 infection in northeast Brazil. Two distinct groups were constructed according to the epidemiological data: first wave and second wave. The severity of patients admitted was estimated using the SAPS 3 score.
Results: A total of 767 patients were included: 290 were enrolled in the first wave and 477 in the second wave. Patients in the first wave had more comorbidities, were put on mechanical ventilation and required dialysis and vasopressors more frequently (p<0.05). During the second wave, non-invasive ventilation was more often required (p<0.05). In both periods, older patients and higher SAPS 3 scores on admission were associated with death (p<0.05). Non-invasive ventilation use showed a negative association with death only in the second wave period. In the first wave, the SAPS 3 score was more useful (area under the curve [AUC] 0.897) in predicting death in critically ill COVID-19 patients than in the second wave (AUC 0.810).
Conclusion: The SAPS 3 showed very reliable predictive values for death during the waves of the COVID-19 pandemic, mostly together with kidney and pulmonary dysfunction.
Keywords: COVID-19; SARS-CoV-2; Simplified Acute Physiology Score; intensive care units; mortality.