tetano
Editor, Senior Moderator
Trans R Soc Trop Med Hyg
. 2021 Jun 29;trab094.
doi: 10.1093/trstmh/trab094. Online ahead of print.
SARS-CoV-2 in eight municipalities of the Colombian tropics: high immunity, clinical and sociodemographic outcomes
Evelin Garay[SUP] 1 [/SUP], Héctor Serrano-Coll[SUP] 1 [/SUP], Ricardo Rivero[SUP] 1 [/SUP], Bertha Gastelbondo[SUP] 1 [/SUP], Álvaro Faccini-Martínez[SUP] 1 [/SUP], José Berrocal[SUP] 1 [/SUP], Alejandra Pérez[SUP] 1 [/SUP], María Badillo[SUP] 1 [/SUP], Caty Martínez-Bravo[SUP] 1 [/SUP], Yesica Botero[SUP] 1 [/SUP], Germán Arrieta[SUP] 1 2 [/SUP], Alfonso Calderón[SUP] 1 [/SUP], Ketty Galeano[SUP] 1 [/SUP], Yesica López[SUP] 1 [/SUP], Jorge Miranda[SUP] 1 [/SUP], Camilo Guzmán[SUP] 1 [/SUP], Verónica Contreras[SUP] 1 [/SUP], Alejandra Arosemena[SUP] 1 [/SUP], Héctor Contreras[SUP] 1 [/SUP], Eimi Brango-Tarra[SUP] 2 [/SUP], Misael Oviedo[SUP] 3 [/SUP], Salim Mattar[SUP] 1 [/SUP]
Affiliations
Abstract
Background: Serological evaluation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an alternative that allows us to determine the prevalence and dynamics of this infection in populations. The goal of this study was to determine the clinical and sociodemographic dynamics of SARS-CoV-2 infection in a region of the Colombian Caribbean.
Methods: Between July and November 2020, a cross-sectional observational study was carried out in Córdoba, located in northeast Colombia in the Caribbean area. Eight municipalities with the largest populations were chosen and 2564 blood samples were taken. A commercial enzyme-linked immunosorbent assay was used with the recombinant protein antigen N of SARS-CoV-2. The people included in the study were asked for sociodemographic and clinical data, which were analysed by statistical methods.
Results: A seroprevalence of 40.8% was obtained for SARS-CoV-2 in the Córdoba region. In the bivariate analysis, no differences were observed in seropositivity against SARS-CoV-2 for gender or age range (p>0.05). Higher seropositivity was found in low socio-economic status and symptomatic patients (p<0.0001). A total of 30.7% of the asymptomatic patients were seropositive for SARS-CoV-2, which could be linked to the spread of this infection. In the multivariate analysis, seroconversion was related to poverty and clinical manifestations such as anosmia and ageusia (p<0.05).
Conclusions: The high seropositivity in Córdoba is due to widespread SARS-CoV-2 in this population. The relationship between seropositivity and socio-economic status suggests a higher exposure risk to the virus caused by informal economic activities in low-income groups. Clinical manifestations such as anosmia and ageusia could be clinical predictors of infection by the new emergent coronavirus.
Keywords: asymptomatic infections; economic conditions; informal social controls; public health; seroepidemiologic studies; social conditions.
. 2021 Jun 29;trab094.
doi: 10.1093/trstmh/trab094. Online ahead of print.
SARS-CoV-2 in eight municipalities of the Colombian tropics: high immunity, clinical and sociodemographic outcomes
Evelin Garay[SUP] 1 [/SUP], Héctor Serrano-Coll[SUP] 1 [/SUP], Ricardo Rivero[SUP] 1 [/SUP], Bertha Gastelbondo[SUP] 1 [/SUP], Álvaro Faccini-Martínez[SUP] 1 [/SUP], José Berrocal[SUP] 1 [/SUP], Alejandra Pérez[SUP] 1 [/SUP], María Badillo[SUP] 1 [/SUP], Caty Martínez-Bravo[SUP] 1 [/SUP], Yesica Botero[SUP] 1 [/SUP], Germán Arrieta[SUP] 1 2 [/SUP], Alfonso Calderón[SUP] 1 [/SUP], Ketty Galeano[SUP] 1 [/SUP], Yesica López[SUP] 1 [/SUP], Jorge Miranda[SUP] 1 [/SUP], Camilo Guzmán[SUP] 1 [/SUP], Verónica Contreras[SUP] 1 [/SUP], Alejandra Arosemena[SUP] 1 [/SUP], Héctor Contreras[SUP] 1 [/SUP], Eimi Brango-Tarra[SUP] 2 [/SUP], Misael Oviedo[SUP] 3 [/SUP], Salim Mattar[SUP] 1 [/SUP]
Affiliations
- PMID: 34185868
- DOI: 10.1093/trstmh/trab094
Abstract
Background: Serological evaluation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an alternative that allows us to determine the prevalence and dynamics of this infection in populations. The goal of this study was to determine the clinical and sociodemographic dynamics of SARS-CoV-2 infection in a region of the Colombian Caribbean.
Methods: Between July and November 2020, a cross-sectional observational study was carried out in Córdoba, located in northeast Colombia in the Caribbean area. Eight municipalities with the largest populations were chosen and 2564 blood samples were taken. A commercial enzyme-linked immunosorbent assay was used with the recombinant protein antigen N of SARS-CoV-2. The people included in the study were asked for sociodemographic and clinical data, which were analysed by statistical methods.
Results: A seroprevalence of 40.8% was obtained for SARS-CoV-2 in the Córdoba region. In the bivariate analysis, no differences were observed in seropositivity against SARS-CoV-2 for gender or age range (p>0.05). Higher seropositivity was found in low socio-economic status and symptomatic patients (p<0.0001). A total of 30.7% of the asymptomatic patients were seropositive for SARS-CoV-2, which could be linked to the spread of this infection. In the multivariate analysis, seroconversion was related to poverty and clinical manifestations such as anosmia and ageusia (p<0.05).
Conclusions: The high seropositivity in Córdoba is due to widespread SARS-CoV-2 in this population. The relationship between seropositivity and socio-economic status suggests a higher exposure risk to the virus caused by informal economic activities in low-income groups. Clinical manifestations such as anosmia and ageusia could be clinical predictors of infection by the new emergent coronavirus.
Keywords: asymptomatic infections; economic conditions; informal social controls; public health; seroepidemiologic studies; social conditions.