Transbound Emerg Dis . Piglets inoculated by different routes are not susceptible to SARS-CoV-2, but those inoculated parenterally were immunized a

[tetano]

Transbound Emerg Dis


. 2020 Oct 2.
doi: 10.1111/tbed.13861. Online ahead of print.
Piglets inoculated by different routes are not susceptible to SARS-CoV-2, but those inoculated parenterally were immunized against the virus


J?lia Vergara-Alert[SUP] 1 2 [/SUP], Jordi Rodon[SUP] 1 [/SUP], Jorge Carrillo[SUP] 3 [/SUP], Nigeer Te[SUP] 1 [/SUP], Nuria Izquierdo-Useros[SUP] 3 4 [/SUP], Mar?a Luisa Rodr?guez de, la Concepci?n[SUP] 3 [/SUP], Carlos ?vila-Nieto[SUP] 3 [/SUP], V?ctor Guallar[SUP] 5 6 [/SUP], Alfonso Valencia[SUP] 5 6 [/SUP], Guillermo Cantero[SUP] 1 [/SUP], Juli? Blanco[SUP] 3 4 7 [/SUP], Bonaventura Clotet[SUP] 3 4 7 [/SUP], Albert Bensaid[SUP] 1 2 [/SUP], Joaquim Segal?s[SUP] 2 8 9 [/SUP]



Affiliations

• PMID: 33007154
• DOI: 10.1111/tbed.13861

Abstract

Conventional piglets were inoculated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) through different routes, including intranasal, intratracheal, intramuscular and intravenous ones. Although piglets were not susceptible to SARS-CoV-2 and lacked lesions or viral RNA in tissues/swabs, seroconversion was observed in pigs inoculated parenterally (intramuscularly or intravenously).

Keywords: SARS-CoV-2; immunogenicity model; inoculation routes; lack of susceptibility; pig.