tetano
Editor, Senior Moderator
J Infect Dis. 2013 Jul 29. [Epub ahead of print]
Transcriptomic profiling in childhood H1N1/09 influenza reveals reduced expression of protein synthesis genes.
Herberg JA, Kaforou M, Gormley S, Sumner ER, Patel S, Jones KD, Paulus S, Fink C, Martinon-Torres F, Montana G, Wright VJ, Levin M.
Source
Section of Paediatrics.
Abstract
We compared the blood RNA transcriptome of children hospitalised with influenza A H1N1/09, RSV or bacterial infection, and healthy controls. Compared to controls, H1N1/09 patients showed increased expression of inflammatory pathway genes, and reduced expression of adaptive immune pathway genes. This was validated on an independent cohort. The most significant function distinguishing H1N1/09 patients from controls was protein synthesis, with reduced gene expression. Reduced expression of protein synthesis genes also characterised the H1N1/09 expression profile compared to children with RSV and bacterial infection, suggesting that this is a key component of the pathophysiological response in children hospitalised with H1N1/09 infection.
PMID:
23901082
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/23901082
Transcriptomic profiling in childhood H1N1/09 influenza reveals reduced expression of protein synthesis genes.
Herberg JA, Kaforou M, Gormley S, Sumner ER, Patel S, Jones KD, Paulus S, Fink C, Martinon-Torres F, Montana G, Wright VJ, Levin M.
Source
Section of Paediatrics.
Abstract
We compared the blood RNA transcriptome of children hospitalised with influenza A H1N1/09, RSV or bacterial infection, and healthy controls. Compared to controls, H1N1/09 patients showed increased expression of inflammatory pathway genes, and reduced expression of adaptive immune pathway genes. This was validated on an independent cohort. The most significant function distinguishing H1N1/09 patients from controls was protein synthesis, with reduced gene expression. Reduced expression of protein synthesis genes also characterised the H1N1/09 expression profile compared to children with RSV and bacterial infection, suggesting that this is a key component of the pathophysiological response in children hospitalised with H1N1/09 infection.
PMID:
23901082
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/23901082