tetano
Editor, Senior Moderator
Transpl Infect Dis
. 2021 Oct 4.
doi: 10.1111/tid.13740. Online ahead of print.
Antibody response to two doses of inactivated SARS-CoV-2 vaccine (CoronaVac) in Kidney Transplant Recipients
Rezzan Eren Sadioğlu[SUP] 1 [/SUP], Erol Demir[SUP] 2 [/SUP], Ebru Evren[SUP] 3 [/SUP], Merve Aktar[SUP] 1 [/SUP], Seda Şafak[SUP] 2 [/SUP], Ayşe Serra Artan[SUP] 2 [/SUP], Sevim Meşe[SUP] 4 [/SUP], Ali Ağaçfidan[SUP] 4 [/SUP], Güle Çınar[SUP] 5 [/SUP], Mustafa Önel[SUP] 4 [/SUP], Zeynep Ceren Karahan[SUP] 3 [/SUP], Şule Şengül[SUP] 1 [/SUP], Kenan Keven[SUP] 1 [/SUP], Aydın Türkmen[SUP] 2 [/SUP]
Affiliations
Abstract
Background: Coronavirus Disease-19 (COVID-19) has a high mortality in kidney transplant recipients (KTR), and vaccination against Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2) is vital for this population. Although humoral response to messenger RNA vaccines was shown to be impaired in KTR, there is a lack of data regarding the antibody response to inactivated vaccines. We investigated the antibody response to two consequent doses of the inactivated SARS-CoV-2 vaccine (CoronaVac, Sinovac Biotech, China).
Methods: A total of 118 patients from two centers were included. The levels of Anti-SARS-CoV-2 IgG antibodies against the nucleocapsid and spike antigens were determined with enzyme immunoassay (DIA.PRO, Milano, Italy) before the vaccine and one month after the second dose of the vaccine. Thirty three patients were excluded due to antibody positivity in the serum samples obtained before vaccination.
Results: Eighty-five patients, 47 of whom were female, with a mean age of 46±12, were included in the statistical analysis. The maintenance immunosuppressive therapy comprised tacrolimus (88.2%), mycophenolate (63.6%), and low dose steroids (95.3%) in the majority of the patients. After a median of 31 days following the second dose of the vaccine, only 16 (18.8%) patients developed an antibody response. The median (IQR) antibody level was 52.5 IU/ml (21.5-96). Age (48 vs 38, p=0.005) and serum creatinine levels (1.14 vs. 0.91, p=0.04) were higher in non-responders, and were also found to be independently associated with the antibody response (OR, 0.93, p=0.012 and 0.15, p=0.045, respectively) in multivariate analysis.
Conclusion: In this study, we found the antibody response to the inactivated vaccine to be considerably low (18.8%) in KTR. Increased age and impaired renal function were associated with worse antibody response. Based on the knowledge that mRNA vaccines yield better humoral responses, this special population might be considered for additional doses of mRNA vaccination. This article is protected by copyright. All rights reserved.
Keywords: COVID-19; SARS-CoV-2; antibody response; inactivated vaccine; renal transplantation.
. 2021 Oct 4.
doi: 10.1111/tid.13740. Online ahead of print.
Antibody response to two doses of inactivated SARS-CoV-2 vaccine (CoronaVac) in Kidney Transplant Recipients
Rezzan Eren Sadioğlu[SUP] 1 [/SUP], Erol Demir[SUP] 2 [/SUP], Ebru Evren[SUP] 3 [/SUP], Merve Aktar[SUP] 1 [/SUP], Seda Şafak[SUP] 2 [/SUP], Ayşe Serra Artan[SUP] 2 [/SUP], Sevim Meşe[SUP] 4 [/SUP], Ali Ağaçfidan[SUP] 4 [/SUP], Güle Çınar[SUP] 5 [/SUP], Mustafa Önel[SUP] 4 [/SUP], Zeynep Ceren Karahan[SUP] 3 [/SUP], Şule Şengül[SUP] 1 [/SUP], Kenan Keven[SUP] 1 [/SUP], Aydın Türkmen[SUP] 2 [/SUP]
Affiliations
- PMID: 34606134
- DOI: 10.1111/tid.13740
Abstract
Background: Coronavirus Disease-19 (COVID-19) has a high mortality in kidney transplant recipients (KTR), and vaccination against Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2) is vital for this population. Although humoral response to messenger RNA vaccines was shown to be impaired in KTR, there is a lack of data regarding the antibody response to inactivated vaccines. We investigated the antibody response to two consequent doses of the inactivated SARS-CoV-2 vaccine (CoronaVac, Sinovac Biotech, China).
Methods: A total of 118 patients from two centers were included. The levels of Anti-SARS-CoV-2 IgG antibodies against the nucleocapsid and spike antigens were determined with enzyme immunoassay (DIA.PRO, Milano, Italy) before the vaccine and one month after the second dose of the vaccine. Thirty three patients were excluded due to antibody positivity in the serum samples obtained before vaccination.
Results: Eighty-five patients, 47 of whom were female, with a mean age of 46±12, were included in the statistical analysis. The maintenance immunosuppressive therapy comprised tacrolimus (88.2%), mycophenolate (63.6%), and low dose steroids (95.3%) in the majority of the patients. After a median of 31 days following the second dose of the vaccine, only 16 (18.8%) patients developed an antibody response. The median (IQR) antibody level was 52.5 IU/ml (21.5-96). Age (48 vs 38, p=0.005) and serum creatinine levels (1.14 vs. 0.91, p=0.04) were higher in non-responders, and were also found to be independently associated with the antibody response (OR, 0.93, p=0.012 and 0.15, p=0.045, respectively) in multivariate analysis.
Conclusion: In this study, we found the antibody response to the inactivated vaccine to be considerably low (18.8%) in KTR. Increased age and impaired renal function were associated with worse antibody response. Based on the knowledge that mRNA vaccines yield better humoral responses, this special population might be considered for additional doses of mRNA vaccination. This article is protected by copyright. All rights reserved.
Keywords: COVID-19; SARS-CoV-2; antibody response; inactivated vaccine; renal transplantation.