tetano
Editor, Senior Moderator
Transplantation
. 2020 Oct 30.
doi: 10.1097/TP.0000000000003508. Online ahead of print.
COVID-19 in Lung Transplant Recipients
Jonathan Messika[SUP] 1 2 3 [/SUP], Philippine Eloy[SUP] 4 5 [/SUP], Antoine Roux[SUP] 3 6 7 [/SUP], Sandrine Hirschi[SUP] 8 [/SUP], Ana Nieves[SUP] 9 [/SUP], J?r?me Le Pavec[SUP] 10 11 12 [/SUP], Agathe S?n?chal[SUP] 13 [/SUP], Christel Saint Raymond[SUP] 14 [/SUP], Nicolas Carlier[SUP] 15 [/SUP], Xavier Demant[SUP] 16 [/SUP], Aur?lie Le Borgne[SUP] 17 [/SUP], Adrien Tissot[SUP] 18 [/SUP], Marie-Pierre Debray[SUP] 19 [/SUP], Laurence Beaumont[SUP] 6 [/SUP], Benjamin Renaud-Picard[SUP] 8 [/SUP], Martine Reynaud-Gaubert[SUP] 9 [/SUP], Jean-Fran?ois Mornex[SUP] 13 20 [/SUP], Lo?c Falque[SUP] 14 [/SUP], V?ronique Boussaud[SUP] 15 [/SUP], Jacques Jougon[SUP] 16 [/SUP], Sacha Mussot[SUP] 10 11 12 [/SUP], Herv? Mal[SUP] 1 2 [/SUP], French Group of Lung Transplantation.
Affiliations
Abstract
Background: A concern about the susceptibility of immunocompromised patients to the worldwide pandemic of coronavirus disease 2019 (COVID-19) has been raised. We aimed at describing COVID-19 infections in the French cohort of lung transplant (LT) patients.
Methods: Multicenter nationwide cohort study of all LT recipients with COVID-19 diagnosed from March 1 to May 19, 2020. Recipient main characteristics and their management were retrieved. Hospitalization characteristics, occurrence of complications and survival were analyzed.
Results: Thirty-five LT patients with a COVID-19 infection were included. Median age was 50.4 [40.6-62.9] years, 16 (45.7%) were female, and 80% were double-LT recipients. Infection was community-acquired in 25 (71.4%). Thirty-one (88.6%) required hospitalization, including 13 (41.9%) in the intensive care unit. The main symptoms of COVID-19 were fever, cough, and diarrhea, present in 71.4%, 54.3%, and 31.4% of cases, respectively. Extension of pneumonia on chest CT was moderate to severe in 51.4% of cases. Among the 13 critically ill patients, 7 (53.9%) received invasive mechanical ventilation. Thrombotic events occurred in 4 patients. Overall survival rate was 85.7% after a median follow-up of 50 days [41.0-56.5]. Four of 5 nonsurvivors had had bronchial complications or intensification of immunosuppression in the previous weeks. On univariate analysis, overweight was significantly associated with risk of death (odds ratio 16.0 [95% confidence interval1.5-170.6], p=0.02).
Conclusion: For the 35 LT recipients with COVID-19, the presentation was severe, requiring hospitalization in most cases, with a survival rate of 85.7%.
. 2020 Oct 30.
doi: 10.1097/TP.0000000000003508. Online ahead of print.
COVID-19 in Lung Transplant Recipients
Jonathan Messika[SUP] 1 2 3 [/SUP], Philippine Eloy[SUP] 4 5 [/SUP], Antoine Roux[SUP] 3 6 7 [/SUP], Sandrine Hirschi[SUP] 8 [/SUP], Ana Nieves[SUP] 9 [/SUP], J?r?me Le Pavec[SUP] 10 11 12 [/SUP], Agathe S?n?chal[SUP] 13 [/SUP], Christel Saint Raymond[SUP] 14 [/SUP], Nicolas Carlier[SUP] 15 [/SUP], Xavier Demant[SUP] 16 [/SUP], Aur?lie Le Borgne[SUP] 17 [/SUP], Adrien Tissot[SUP] 18 [/SUP], Marie-Pierre Debray[SUP] 19 [/SUP], Laurence Beaumont[SUP] 6 [/SUP], Benjamin Renaud-Picard[SUP] 8 [/SUP], Martine Reynaud-Gaubert[SUP] 9 [/SUP], Jean-Fran?ois Mornex[SUP] 13 20 [/SUP], Lo?c Falque[SUP] 14 [/SUP], V?ronique Boussaud[SUP] 15 [/SUP], Jacques Jougon[SUP] 16 [/SUP], Sacha Mussot[SUP] 10 11 12 [/SUP], Herv? Mal[SUP] 1 2 [/SUP], French Group of Lung Transplantation.
Affiliations
- PMID: 33141808
- DOI: 10.1097/TP.0000000000003508
Abstract
Background: A concern about the susceptibility of immunocompromised patients to the worldwide pandemic of coronavirus disease 2019 (COVID-19) has been raised. We aimed at describing COVID-19 infections in the French cohort of lung transplant (LT) patients.
Methods: Multicenter nationwide cohort study of all LT recipients with COVID-19 diagnosed from March 1 to May 19, 2020. Recipient main characteristics and their management were retrieved. Hospitalization characteristics, occurrence of complications and survival were analyzed.
Results: Thirty-five LT patients with a COVID-19 infection were included. Median age was 50.4 [40.6-62.9] years, 16 (45.7%) were female, and 80% were double-LT recipients. Infection was community-acquired in 25 (71.4%). Thirty-one (88.6%) required hospitalization, including 13 (41.9%) in the intensive care unit. The main symptoms of COVID-19 were fever, cough, and diarrhea, present in 71.4%, 54.3%, and 31.4% of cases, respectively. Extension of pneumonia on chest CT was moderate to severe in 51.4% of cases. Among the 13 critically ill patients, 7 (53.9%) received invasive mechanical ventilation. Thrombotic events occurred in 4 patients. Overall survival rate was 85.7% after a median follow-up of 50 days [41.0-56.5]. Four of 5 nonsurvivors had had bronchial complications or intensification of immunosuppression in the previous weeks. On univariate analysis, overweight was significantly associated with risk of death (odds ratio 16.0 [95% confidence interval1.5-170.6], p=0.02).
Conclusion: For the 35 LT recipients with COVID-19, the presentation was severe, requiring hospitalization in most cases, with a survival rate of 85.7%.