tetano
Editor, Senior Moderator
Trends Immunol
. 2020 Oct 15;S1471-4906(20)30234-9.
doi: 10.1016/j.it.2020.10.005. Online ahead of print.
Coronaviruses: Innate Immunity, Inflammasome Activation, Inflammatory Cell Death, and Cytokines
SangJoon Lee[SUP] 1 [/SUP], Rudragouda Channappanavar[SUP] 2 [/SUP], Thirumala-Devi Kanneganti[SUP] 3 [/SUP]
Affiliations
Abstract
The innate immune system acts as the first line of defense against pathogens, including coronaviruses (CoVs). Severe acute respiratory syndrome (SARS)-CoV and Middle East respiratory syndrome (MERS)-CoV are epidemic zoonotic CoVs that emerged at the beginning of the 21st century. The recently emerged virus SARS-CoV-2 is a novel strain of CoV that has caused the coronavirus 2019 (COVID-19) pandemic. Scientific advancements made by studying the SARS-CoV and MERS-CoV outbreaks have provided a foundation for understanding pathogenesis and innate immunity against SARS-CoV-2. In this review, we focus on our present understanding of innate immune responses, inflammasome activation, inflammatory cell death pathways, and cytokine secretion during SARS-CoV, MERS-CoV, and SARS-CoV-2 infection. We also discuss how the pathogenesis of these viruses influences these biological processes.
Keywords: COVID-19; MERS-CoV; MHV; PANoptosis; PANoptosome; RNA virus; SARS-CoV; SARS-CoV-2; cell death; coronavirus; cytokines; inflammasome; inflammation; innate immunity.
. 2020 Oct 15;S1471-4906(20)30234-9.
doi: 10.1016/j.it.2020.10.005. Online ahead of print.
Coronaviruses: Innate Immunity, Inflammasome Activation, Inflammatory Cell Death, and Cytokines
SangJoon Lee[SUP] 1 [/SUP], Rudragouda Channappanavar[SUP] 2 [/SUP], Thirumala-Devi Kanneganti[SUP] 3 [/SUP]
Affiliations
- PMID: 33153908
- DOI: 10.1016/j.it.2020.10.005
Abstract
The innate immune system acts as the first line of defense against pathogens, including coronaviruses (CoVs). Severe acute respiratory syndrome (SARS)-CoV and Middle East respiratory syndrome (MERS)-CoV are epidemic zoonotic CoVs that emerged at the beginning of the 21st century. The recently emerged virus SARS-CoV-2 is a novel strain of CoV that has caused the coronavirus 2019 (COVID-19) pandemic. Scientific advancements made by studying the SARS-CoV and MERS-CoV outbreaks have provided a foundation for understanding pathogenesis and innate immunity against SARS-CoV-2. In this review, we focus on our present understanding of innate immune responses, inflammasome activation, inflammatory cell death pathways, and cytokine secretion during SARS-CoV, MERS-CoV, and SARS-CoV-2 infection. We also discuss how the pathogenesis of these viruses influences these biological processes.
Keywords: COVID-19; MERS-CoV; MHV; PANoptosis; PANoptosome; RNA virus; SARS-CoV; SARS-CoV-2; cell death; coronavirus; cytokines; inflammasome; inflammation; innate immunity.