tetano
Editor, Senior Moderator
Trends Immunol
. 2020 Nov 13;S1471-4906(20)30260-X.
doi: 10.1016/j.it.2020.11.002. Online ahead of print.
T Cells: Warriors of SARS-CoV-2 Infection
Paola de Candia[SUP] 1 [/SUP], Francesco Prattichizzo[SUP] 2 [/SUP], Silvia Garavelli[SUP] 3 [/SUP], Giuseppe Matarese[SUP] 4 [/SUP]
Affiliations
Abstract
Severe infection with severe acute respiratory syndrome coronavirus (SARS-CoV)-2 is characterized by massive cytokine release and T cell loss. The exaggerated host immune response, incapable of viral clearance, instead aggravates respiratory distress, as well as cardiac, and/or damage to other organs. The mortality pattern of SARS-CoV-2 infection, higher in older versus younger adults and almost absent in children, is possibly caused by the effects of age and pre-existing comorbidities on innate and adaptive immunity. Here, we speculate that the abnormal and excessive immune response to SARS-CoV-2 infection partly depends on T cell immunological memory, which is more pronounced in adults compared with children, and may significantly contribute to immunopathology and massive collateral damage in coronavirus disease 2019 (COVID-19) patients.
. 2020 Nov 13;S1471-4906(20)30260-X.
doi: 10.1016/j.it.2020.11.002. Online ahead of print.
T Cells: Warriors of SARS-CoV-2 Infection
Paola de Candia[SUP] 1 [/SUP], Francesco Prattichizzo[SUP] 2 [/SUP], Silvia Garavelli[SUP] 3 [/SUP], Giuseppe Matarese[SUP] 4 [/SUP]
Affiliations
- PMID: 33277181
- DOI: 10.1016/j.it.2020.11.002
Abstract
Severe infection with severe acute respiratory syndrome coronavirus (SARS-CoV)-2 is characterized by massive cytokine release and T cell loss. The exaggerated host immune response, incapable of viral clearance, instead aggravates respiratory distress, as well as cardiac, and/or damage to other organs. The mortality pattern of SARS-CoV-2 infection, higher in older versus younger adults and almost absent in children, is possibly caused by the effects of age and pre-existing comorbidities on innate and adaptive immunity. Here, we speculate that the abnormal and excessive immune response to SARS-CoV-2 infection partly depends on T cell immunological memory, which is more pronounced in adults compared with children, and may significantly contribute to immunopathology and massive collateral damage in coronavirus disease 2019 (COVID-19) patients.