tetano
Editor, Senior Moderator
Trends Mol Med
. 2022 Feb 14;S1471-4914(22)00045-4.
doi: 10.1016/j.molmed.2022.02.004. Online ahead of print.
COVID-19 in pregnancy: implications for fetal brain development
Lydia L Shook[SUP] 1 [/SUP], Elinor L Sullivan[SUP] 2 [/SUP], Jamie O Lo[SUP] 3 [/SUP], Roy H Perlis[SUP] 4 [/SUP], Andrea G Edlow[SUP] 5 [/SUP]
Affiliations
Abstract
The impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection during pregnancy on the developing fetal brain is poorly understood. Other antenatal infections such as influenza have been associated with adverse neurodevelopmental outcomes in offspring. Although vertical transmission has been rarely observed in SARS-CoV-2 to date, given the potential for profound maternal immune activation (MIA), impact on the developing fetal brain is likely. Here we review evidence that SARS-CoV-2 and other viral infections during pregnancy can result in maternal, placental, and fetal immune activation, and ultimately in offspring neurodevelopmental morbidity. Finally, we highlight the need for cellular models of fetal brain development to better understand potential short- and long-term impacts of maternal SARS-CoV-2 infection on the next generation.
Keywords: COVID-19; SARS-CoV-2; fetal brain; neurodevelopment; placenta; pregnancy.
. 2022 Feb 14;S1471-4914(22)00045-4.
doi: 10.1016/j.molmed.2022.02.004. Online ahead of print.
COVID-19 in pregnancy: implications for fetal brain development
Lydia L Shook[SUP] 1 [/SUP], Elinor L Sullivan[SUP] 2 [/SUP], Jamie O Lo[SUP] 3 [/SUP], Roy H Perlis[SUP] 4 [/SUP], Andrea G Edlow[SUP] 5 [/SUP]
Affiliations
- PMID: 35277325
- DOI: 10.1016/j.molmed.2022.02.004
Abstract
The impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection during pregnancy on the developing fetal brain is poorly understood. Other antenatal infections such as influenza have been associated with adverse neurodevelopmental outcomes in offspring. Although vertical transmission has been rarely observed in SARS-CoV-2 to date, given the potential for profound maternal immune activation (MIA), impact on the developing fetal brain is likely. Here we review evidence that SARS-CoV-2 and other viral infections during pregnancy can result in maternal, placental, and fetal immune activation, and ultimately in offspring neurodevelopmental morbidity. Finally, we highlight the need for cellular models of fetal brain development to better understand potential short- and long-term impacts of maternal SARS-CoV-2 infection on the next generation.
Keywords: COVID-19; SARS-CoV-2; fetal brain; neurodevelopment; placenta; pregnancy.