tetano
Editor, Senior Moderator
Eur J Immunol. 2016 Oct 4. doi: 10.1002/eji.201646548. [Epub ahead of print]
[h=1]Type I IFN signaling facilitates the development of IL-10-producing effector CD8+ T cells during murine influenza virus infection.[/h] Jiang L[SUP]1,[/SUP][SUP]2[/SUP], Yao S[SUP]1,[/SUP][SUP]2[/SUP], Huang S[SUP]1,[/SUP][SUP]2[/SUP], Wright J[SUP]3[/SUP], Braciale TJ[SUP]3[/SUP], Sun J[SUP]4,[/SUP][SUP]5[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Recent evidence has suggested that IL-10-producing effector CD8[SUP]+[/SUP] T cells play an important role in regulating excessive inflammation during acute viral infections. However, the cellular and molecular cues regulating the development of IL-10-producing effector CD8[SUP]+[/SUP] T cells are not completely defined. Here we show that type I interferons (IFNs) are required for the development of IL-10-producing effector CD8[SUP]+[/SUP] T cells during influenza virus infection in mice. We find that type I IFNs can enhance IL-27 production by lung antigen presenting cells, thereby facilitating IL-10-producing CD8[SUP]+[/SUP] T-cell development through a CD8[SUP]+[/SUP] T cell non-autonomous way. Surprisingly, we also demonstrate that direct type I IFN signaling in CD8[SUP]+[/SUP] T cells is required for the maximal generation of IL-10-producing CD8[SUP]+[/SUP] T cells. Type I IFN signaling in CD8[SUP]+[/SUP] T cells, in cooperation with IL-27 and IL-2 signaling, promotes and sustains the expression of IRF4 and Blimp-1, two transcription factors required for the production of IL-10 by effector CD8[SUP]+[/SUP] T cells. Our data reveal a critical role of the innate antiviral effector cytokines in regulating the production of a regulatory cytokine by effector CD8[SUP]+[/SUP] T cells during respiratory virus infection. This article is protected by copyright. All rights reserved.
This article is protected by copyright. All rights reserved.
[h=4]KEYWORDS:[/h] CD8+ T cells; IL-10; IL-27; Influenza; Type I IFN
PMID: 27701741 DOI: 10.1002/eji.201646548
[PubMed - as supplied by publisher]
[h=1]Type I IFN signaling facilitates the development of IL-10-producing effector CD8+ T cells during murine influenza virus infection.[/h] Jiang L[SUP]1,[/SUP][SUP]2[/SUP], Yao S[SUP]1,[/SUP][SUP]2[/SUP], Huang S[SUP]1,[/SUP][SUP]2[/SUP], Wright J[SUP]3[/SUP], Braciale TJ[SUP]3[/SUP], Sun J[SUP]4,[/SUP][SUP]5[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Recent evidence has suggested that IL-10-producing effector CD8[SUP]+[/SUP] T cells play an important role in regulating excessive inflammation during acute viral infections. However, the cellular and molecular cues regulating the development of IL-10-producing effector CD8[SUP]+[/SUP] T cells are not completely defined. Here we show that type I interferons (IFNs) are required for the development of IL-10-producing effector CD8[SUP]+[/SUP] T cells during influenza virus infection in mice. We find that type I IFNs can enhance IL-27 production by lung antigen presenting cells, thereby facilitating IL-10-producing CD8[SUP]+[/SUP] T-cell development through a CD8[SUP]+[/SUP] T cell non-autonomous way. Surprisingly, we also demonstrate that direct type I IFN signaling in CD8[SUP]+[/SUP] T cells is required for the maximal generation of IL-10-producing CD8[SUP]+[/SUP] T cells. Type I IFN signaling in CD8[SUP]+[/SUP] T cells, in cooperation with IL-27 and IL-2 signaling, promotes and sustains the expression of IRF4 and Blimp-1, two transcription factors required for the production of IL-10 by effector CD8[SUP]+[/SUP] T cells. Our data reveal a critical role of the innate antiviral effector cytokines in regulating the production of a regulatory cytokine by effector CD8[SUP]+[/SUP] T cells during respiratory virus infection. This article is protected by copyright. All rights reserved.
This article is protected by copyright. All rights reserved.
[h=4]KEYWORDS:[/h] CD8+ T cells; IL-10; IL-27; Influenza; Type I IFN
PMID: 27701741 DOI: 10.1002/eji.201646548
[PubMed - as supplied by publisher]