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U. of Navarre Biosafety Level 3 Lab

Shiloh

Editor, Senior Moderator
Source: http://www.europapress.es/navarra/n...bioseguridad-nivel-espana-20090408132424.html

La CUN cuenta con uno de los primeros laboratorios cl?nicos de bioseguridad de nivel 3 de Espa?a

Google translation:
The CUN has one of the first clinical laboratories of biosafety level 3 Spain
Allows handling of microorganisms that cause diseases such as Anthrax, avian influenza or tuberculosis


PAMPLONA, Apr 8. (EUROPA PRESS) --

Clinic of the University of Navarre has a laboratory of biosafety level 3 which allows the handling of biological agents that cause potentially lethal diseases to humans such as Anthrax, avian influenza and tuberculosis, among others. This is one of the first clinical laboratories of this type launched in Spain.

The security level of the laboratories are classified into four levels according to risk of infection showing the various biological agents. The most dangerous are the level 3 and 4. Specifically, within the level 3, including those "micro-organisms that can cause severe disease in humans, have high potential for transmission, but there are treatments or vaccines against them", explains Dr. Jose Leiva Leon, director of the Microbiology Service Clinic of the University of Navarre, who owns the laboratory. The risk level is the highest biological 4, where there is no effective prophylaxis or treatment for the disease caused.

In addition to the biosecurity measures required by such facilities, the laboratory of the University Clinic of Navarre system adds features to ensure the containment of pathogens within the site.

The activity of the laboratory focuses on the isolation and cultivation of microorganisms, identification, study of the efficacy of anti-infective agents (treatment) and, finally, the sterilization of the samples and managed crops.

Says Dr. Leiva, "the first step is to isolate the microorganisms in a culture medium from clinical samples, at which time its concentration increases and consequently the danger of handling, resulting, at times, their level of risk may come to move from level 2 to level 3. "

Once the microorganism is carried out tests to determine the most appropriate treatment, which is to analyze the susceptibility of the pathogenic microbial agents capable of interfering with their growth and viability. In the case of microbacterias, causing tuberculosis, is an antibiotic to which antibiotics are known to sensitive "

In addition to the causative agents of Anthrax, tuberculosis and avian influenza, laboratory biosafety level 3 of the University Clinic of Navarre is designed to work with the virus that causes dengue or for research on HIV.

Similarly, in their facilities can be analyzed samples of Creutzfeldt-Jakob disease, known as' mad cow disease ', and the bacteria that cause brucellosis and tularemia. Other microorganisms are capable of being operated fungi that cause infections such as histoplasmosis, blastomycosis or paracoccidioidomycosis the disease that is endemic in Central and South America.

The samples, specifically Dr. Leiva come in for the most part of the clinical and public hospitals Navarre. In his view, the surge of cases of tuberculosis among the pathogens that is dedicated to the daily work of the laboratory or the emergence of unusual fungal infections in Spain may be due to population movements that are currently both by immigration and by tourism, which facilitates the introduction of micro-organisms coming from other parts of the world. "

Furthermore, it is the reference laboratory in Navarre in the national surveillance system for influenza. "When the campaign starts from the flu, doctors who are part of the sentinel network in Navarre send us samples of patients suspected of having the disease to proceed to the isolation, identification and typing of strains," he explains.

The aim is to check whether the vaccine in force adequately protect information and have the virus for the preparation of the vaccine the following year. Although not required to manipulate the common flu virus in a laboratory level 3 as the reference laboratory can receive samples of patients with suspected bird flu viruses that do require this level of biosecurity, as the director of the Microbiology Clinic of the University of Navarre. Also, the laboratory may be substances that could be used as biological weapons in attacks.
 
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