UK: 607 confirmed fatalities due to influenza

NS1 · Jan 10, 2011

Re: UK: Reports of Approximately 57 Deaths and 800+ Patients in intensive care (50 deaths confirmed by HPA as for Jan. 06 2011) due to influenza

Re: UK: Reports of Approximately 57 Deaths and 800+ Patients in intensive care (50 deaths confirmed by HPA as for Jan. 06 2011) due to influenza

Toaster2 said:
Just a question. Can anyone give a short and comprehensive response to these questions ? I see a huge amount of data and analyses and have lost the overview:

The changes in aa 188 and 186: As I understand these are in about half of teh UK sequences. Are they expected to be linked to the severity and vaccine escape ?

188T may be related to VxX, but not verified yet. Severity is not determined due to lack of data being published.

D225G: only present in 2 of the sequences ?

Yes, only 2. The essential description of this UK sequence set is Divergence.

H275Y: Tamiflu resitance - I saw somewhere that this is getting fixed in this years H1n1. Is this correct ?

More than 100 sequences in US and Asia, but not fixed with 275Y yet.

In other words: Are the novel sequences as alarming as for example suggested by HenryN or is there "no cause for concern" ?

Of vital concern due to viral reservoir behaviour in the hosts.

Novelty is always a problem. Novelty that also appears in multiple animal reservoirs from known human-infective / donation serotypes increases the potential for a "confused" virus and the potential for severity.

tetano · Jan 10, 2011

Re: UK: Reports of Approximately 57 Deaths and 800+ Patients in intensive care (50 deaths confirmed by HPA as for Jan. 06 2011) due to influenza

Re: UK: Reports of Approximately 57 Deaths and 800+ Patients in intensive care (50 deaths confirmed by HPA as for Jan. 06 2011) due to influenza

Liverpool council manager dies of swine flu

A DAD-OF-TWO who became ill during his birthday celebrations died two weeks later from swine flu.

David Hanson fell ill while having a meal with his family for his 59th birthday, on December 16.

Mr Hanson was a marketing manager at Liverpool City Council who worked on a number of key regeneration projects across the city.

His wife of 30 years, Carol, said it was first thought he had a bad cold which developed into a chest infection until the morning of December 23 when he became ?delirious?.

http://www.liverpoolecho.co.uk/live...il-manager-dies-of-swine-flu-100252-27957851/

Anne · Jan 10, 2011

Re: UK: Reports of Approximately 57 Deaths and 800+ Patients in intensive care (50 deaths confirmed by HPA as for Jan. 06 2011) due to influenza

Re: UK: Reports of Approximately 57 Deaths and 800+ Patients in intensive care (50 deaths confirmed by HPA as for Jan. 06 2011) due to influenza

Local man dies from Swine Flu

North Belfast News 10th of January 2011

By Kieran Hughes

http://www.belfastmedia.com/home_article.php?ID=2281

A North Belfast man

has died from swine flu despite previoulsy being in good health.
Paul Morrissey, who was born and bred in the New Lodge, died yesterday morning (Wednesday) after being admitted to the Royal Victoria Hospital on Tuesday evening.
Fifty two year old Paul, who was brought up in Pim Street but who had been living in Cavendish Street off the Falls Road, had been sick for a couple of days before going to hospital, his ex-wife Susan told the North Belfast News.
And, although his death was first attributed to pneumonia and multiple-organ failure, the family was subsequently contacted by the health authorities who informed them the cause of death was swine flu.

JJackson · Jan 10, 2011

Re: UK: Reports of Approximately 57 Deaths and 800+ Patients in intensive care (50 deaths confirmed by HPA as for Jan. 06 2011) due to influenza

Re: UK: Reports of Approximately 57 Deaths and 800+ Patients in intensive care (50 deaths confirmed by HPA as for Jan. 06 2011) due to influenza

I have posted some thoughts (all stricktly mine not FluTrackers') on the current situation as post #38 in the UK Genetic Evaluation thread (not wanting to clog this news thread with too much speculation on the meaning of the available sequence data - and it is rather long). It in part addresses Toaster2’s question and addresses some points raised in posts by ironorehopper, mixin and NS1. It looks at phylogenic analysis, vaccine escape, anti-viral resistance, sequence collection, limitations of correlating sequences to severity and other issues. I am sure some will not agree with all - or possibly any - of my conclusion but the other thread is a better venue for discussion and speculation.

tetano · Jan 11, 2011

Re: UK: Reports of Approximately 57 Deaths and 800+ Patients in intensive care (50 deaths confirmed by HPA as for Jan. 06 2011) due to influenza

Re: UK: Reports of Approximately 57 Deaths and 800+ Patients in intensive care (50 deaths confirmed by HPA as for Jan. 06 2011) due to influenza

Liverpool Royal Hospital chief says ?we are coping with swine flu?

HOSPITAL chiefs assured patients the city was coping with the swine flu outbreak last night.

Health bosses said although Liverpool wards were seeing a high number of seriously ill flu patients, everything was under control.

At least nine people in Merseyside have died from the H1N1 strain so far this winter.

Figures released on Friday showed cases were going down, but Liverpool still has much higher rates than average.

Diane Wake, Director of nursing and operations at the Royal Liverpool and Broadgreen hospitals, said the trust had increased its intensive care capacity from 13 beds to 20, but that they were not all currently being used.

All Merseyside hospitals have been told to cancel none emergency operations when necessary by the strategic health authority, to accommodate serious flu patients. But Ms Wake said procedures were still going ahead.

She added that flu patients have continued to come to A&E, and urged people to stop.

http://www.liverpooldailypost.co.uk...-we-are-coping-with-swine-flu-92534-27963155/

tetano · Jan 11, 2011

Re: UK: Reports of Approximately 57 Deaths and 800+ Patients in intensive care (50 deaths confirmed by HPA as for Jan. 06 2011) due to influenza

Re: UK: Reports of Approximately 57 Deaths and 800+ Patients in intensive care (50 deaths confirmed by HPA as for Jan. 06 2011) due to influenza

WAG gives GPs vote of confidence over flu jabs

DOCTORS were last night given a vote of confidence as the Assembly Government said there were no plans to strip GP practices of the responsibility for ordering flu vaccines.

Officials said GPs were well placed to ensure Wales had sufficient stocks of the jab in the future as it emerged more than one in 10 people had already been immunised.

Supplies of the last year?s swine flu vaccine will continue to be sent to GP practices that have run out of this year?s seasonal flu jabs in the response to extra demand from patients.

Prime Minister David Cameron had raised the spectre of flu vaccines being ordered centrally by the Department of Health following reports of shortages across the UK.

..

http://www.walesonline.co.uk/news/w...e-of-confidence-over-flu-jabs-91466-27963338/

tetano · Jan 11, 2011

Re: UK: Reports of Approximately 57 Deaths and 800+ Patients in intensive care (50 deaths confirmed by HPA as for Jan. 06 2011) due to influenza

Re: UK: Reports of Approximately 57 Deaths and 800+ Patients in intensive care (50 deaths confirmed by HPA as for Jan. 06 2011) due to influenza

It was a week and then she was gone: Fit and healthy mother-of-three dies from swine flu

A pharmacy worker and mother-of-three has died of swine flu.

Lindsay Goddard, 36, was described by her family as fit and healthy. She thought she just had a cold, and took over-the-counter medication.

But she became seriously ill with the H1N1 virus and died 10 days later. She was rushed into hospital and put on a ventilator when she started struggling for breath.

She was treated for a week with Tamiflu but the virus caused internal bleeding to her bowel and damage to her liver. Despite two operations, doctors at Royal Blackburn Hospital, Lancashire, couldn't save her.

Ms Goddard, a healthcare assistant at St Peter's Pharmacy in Burnley would normally have received the swine flu vaccine at work - but she'd been on long-term leave.
She'd caught suspected swine flu the year before, but had overcome it after being prescribed Tamiflu.
...

http://www.dailymail.co.uk/health/a...-mother-dies-swine-flu.html?ito=feeds-newsxml

tetano · Jan 11, 2011

Re: UK: Reports of Approximately 57 Deaths and 800+ Patients in intensive care (50 deaths confirmed by HPA as for Jan. 06 2011) due to influenza

Re: UK: Reports of Approximately 57 Deaths and 800+ Patients in intensive care (50 deaths confirmed by HPA as for Jan. 06 2011) due to influenza

'Fit and healthy' former bouncer, 44, dies of swine flu

'Fit and healthy' former bouncer, 44, dies of swine flu
Premium Article !

Published Date: 11 January 2011
The fiancee of a South Yorkshire man who died after contracting swine flu has shared her shock at how quickly the "fit and healthy" former bouncer succumbed to the virus.
Dean Brown from East Herringthorpe, Rotherham, died last Wednesday - six days after being taken into Rotherham Hospital. He is one of four people from the borough to have died with swine flu recently.

The 44-year-old's fiancee Sandra Kelsall, who received an eternity ring from the 'gentle giant' on Boxing Day, said he suffered from no underlying health complaints. "He was a fit man," she added.

Professor Walid Al-Wali, medical director at Rotherham Hospital, agreed and said: "He was quite healthy and did sport and gym work.

"Unfortunately, he died despite aggressive treatment and was confirmed to have swine flu."

The other deaths in the area include a 16-year-old who died at home and two 52-year-olds who died in hospital. They all had other health problems, but swine flu was a "contributory factor" in their deaths.

http://www.thestar.co.uk/rotherham/39Fit-and-healthy39-former-bouncer.6685879.jp

tetano · Jan 11, 2011

Re: UK: Reports of Approximately 57 Deaths and 800+ Patients in intensive care (50 deaths confirmed by HPA as for Jan. 06 2011) due to influenza

Re: UK: Reports of Approximately 57 Deaths and 800+ Patients in intensive care (50 deaths confirmed by HPA as for Jan. 06 2011) due to influenza

FLU: ONE DEAD AND THREE IN INTENSIVE CARE

ONE patient with swine flu has died and three others are currently in intensive care at Warwick Hospital, it was confirmed yesterday

In Coventry and Warwickshire, four patients with swine flu have died this winter, but an NHS Warwickshire spokeswoman said it could not be confirmed that they had died directly as a result of the disease.

She said that swine flu was part of seasonal flu which caused deaths every winter: ?We are not seeing abnormal levels of death this year from seasonal flu (including the swine flu strain), but we are seeing a different demographic of people affected.

?We?re generally seeing a younger demographic affected, whereas generally seasonal flu tends to affect older people more severely.?

http://www.stratford-herald.com/mainstory.php?ID=2532

tetano · Jan 11, 2011

Re: UK: Reports of Approximately 57 Deaths and 800+ Patients in intensive care (50 deaths confirmed by HPA as for Jan. 06 2011) due to influenza

Re: UK: Reports of Approximately 57 Deaths and 800+ Patients in intensive care (50 deaths confirmed by HPA as for Jan. 06 2011) due to influenza

Swine flu figures in Warrington high according to Health Protection Agency

LEVELS of swine flu in Warrington are the third highest in the north west.

According to the Health Protection Agency 108.8 people per 100,000 had flu in the last week of December compared to 82 the previous week with 69 confirmed cases. A more recent set of results will be published at the end of this week.

In Liverpool the rate was 88.5 per 100,000, in Manchester it was 83.5 and worst hit was Stockport at 147.

In spite of its high rate NHS Warrington confirmed it currently has enough swine flu vaccine to give to at risk patients across the borough.

http://www.warringtonguardian.co.uk...lu_in_Warrington_third_highest_in_north_west/

tetano · Jan 11, 2011

Re: UK: Reports of Approximately 57 Deaths and 800+ Patients in intensive care (50 deaths confirmed by HPA as for Jan. 06 2011) due to influenza

Re: UK: Reports of Approximately 57 Deaths and 800+ Patients in intensive care (50 deaths confirmed by HPA as for Jan. 06 2011) due to influenza

Swine flu victim from Greater Manchester makes jab plea

A swine flu victim from Greater Manchester who was given hours to live is urging people to get the flu jab.

Before contracting the illness, Phil Smith from Sale was a fit and active person but spent almost four weeks in intensive care over Christmas.

At one point, his partner Vicky Culshaw was told it was unlikely he would "make it through the night".

Phil is now urging everyone, whether they're at risk or not, to see their GP about getting vaccinated.

..

http://news.bbc.co.uk/local/manchester/hi/people_and_places/newsid_9357000/9357955.stm

tetano · Jan 11, 2011

Re: UK: Reports of Approximately 57 Deaths and 800+ Patients in intensive care (50 deaths confirmed by HPA as for Jan. 06 2011) due to influenza

Re: UK: Reports of Approximately 57 Deaths and 800+ Patients in intensive care (50 deaths confirmed by HPA as for Jan. 06 2011) due to influenza

Wirral swine flu cases down

FLU cases in Wirral have dropped but remain high.

According to Health Protection Agency (HPA) figures, 86.1 people per 100,000 had flu in the last week of December, compared to 91.4 the week before.

Experts said the drop should be looked at with caution, because the closure of schools and work holidays may have reduced the spread.

The figures are used only as a guide, because not all GP surgeries report cases, and several would have closed over the holiday period.

...

http://www.wirralnews.co.uk/wirral-...2/wirral-swine-flu-cases-down-80491-27967755/

Ronan Kelly · Jan 11, 2011

Re: UK: Reports of Approximately 57 Deaths and 800+ Patients in intensive care (50 deaths confirmed by HPA as for Jan. 06 2011) due to influenza

Re: UK: Reports of Approximately 57 Deaths and 800+ Patients in intensive care (50 deaths confirmed by HPA as for Jan. 06 2011) due to influenza

:tiphat: monotreme @ PFI

Health Unit Reports London's First Flu-Related Death
Miranda Chant
1/11/2011

The London region has had its first influenza related death of the year.

The Middlesex London Health Unit says an elderly person, who had existing medical issues and tested positive for influenza, died between December 30th and January 6th.

The health unit also reports there were 15 new lab confirmed cases of influenza during the same time period.

10 of the cases were within the community while the other 5 were institutional outbreaks.

...

http://www.cjbk.com/LocalNews/Story.aspx?ID=1341706

JimO · Jan 11, 2011

Re: UK: Reports of Approximately 57 Deaths and 800+ Patients in intensive care (50 deaths confirmed by HPA as for Jan. 06 2011) due to influenza

Re: UK: Reports of Approximately 57 Deaths and 800+ Patients in intensive care (50 deaths confirmed by HPA as for Jan. 06 2011) due to influenza

I'm not sure how we want to handle these types of reports, but at the beginning when we were first tracking fatalities in Argentina, we tracked confirmed and suspected cases. This report would be sufficient to make the total for Wales 57. For the time being, I'll keep a separate list of suspected fatalities, but for some reason public health agencies seem to always want to downplay the impacts of this virus.

RoRo said:
Just want to emphasize this point from one of Tetano's posts earlier. This states that the number of flu related deaths in Wales is 57 not 12. Applying the same factor of 5 to the UK as a whole suggests around 250 fatalities with confirmed flu involvement.

NS1 · Jan 12, 2011

UK Severe Wave Demonstrates Diversity with Vaccine Escape Positional Changes

UK Severe Wave Demonstrates Diversity with Vaccine Escape Positional Changes

UK Severe Wave Demonstrates Diversity with Vaccine Escape Positional Changes

The UK Health Protection Agency released a group of 37 sequences at GISAID dated 2010-01-05 that appeared sometime after that date. Some of the sequences in this deposit also appear on the Figure 3 Phylogenetic Tree from the HPA Eurosurveilance paper requested to be cited as:

Ellis J, Galiano M, Pebody R, Lackenby A, Thompson C, Bermingham A, McLean E, Zhao H, Bolotin S, Dar O, Watson JM, Zambon M. Virological analysis of fatal influenza cases in the United Kingdom during the early wave of influenza in winter 2010/11. Euro Surveill. 2011;16(1)

ii=19760. 
Available online:
<a href="http://www.eurosurveillance.org/ViewArticle.aspx?ArticleId=19760" target="_blank">http://www.eurosurveillance.org/ViewArticle.aspx?ArticleId=19760</a> 
Date of submission: 31 December 2010

Amino acid positions 158 and 159 have been tracked with changes associated with multiple "Low Reactor" specimens.

188T with 225G - UKEngland4880378_2010_12 [<a href="http://pf11.blogspot.com/2011/01/uk-severe-wave-sequences-show-no.html">Link</a>]
188T with 158E - UKEngland106_2010_11

Where is 188T with 158E and 225G similar to domained 156E, 188T and 225G on <a href="http://pf11.blogspot.com/2010/12/ha-225g-paired-with-188t-in-diverse.html" target="_blank">OzBrisbane209_51F_2010_08_09</a>?

<a href="http://genewurx.com/data/GeneWurx_UK_December_Emerging_Genetics_v4.xls" target="_blank">GeneWurx_UK_December_Emerging_Genetics_v4.xls</a>

. . . . UKEngland106_2010_11 (
. . . . . . . . 0A,
. . . . . . . . syn55L,
. . . . . . . . 158E mix wt,
. . . . . . . . 188T,
. . . . . . . . syn258F [RussiaPermCREI_ZTS_2009_11_30
. . . . . . . . . . . . . . . . . . with 0A, 377K],
. . . . . . . . syn338G,
. . . . . . . . 377K,
. . . . . . . . 452I [H3N8 nucleotide donor],
. . . . . . . . . . . . [H11 nucleotide donor],
. . . . . . . . 454N,
. . . . . . . . syn529L)

. . . . UKEngland3380426_2010_08 (
. . . . . . . . syn44L,
. . . . . . . . syn106E,
. . . . . . . . 128D,
. . . . . . . . 159K [NY3230_2010_01_25
. . . . . . . . . . . . with 100N, syn177L, syn231N],
. . . . . . . . 377K)

tetano · Jan 12, 2011

Re: UK: Reports of Approximately 73 Deaths and 800+ Patients in intensive care (50 deaths confirmed by HPA as for Jan. 06 2011) due to influenza

Re: UK: Reports of Approximately 73 Deaths and 800+ Patients in intensive care (50 deaths confirmed by HPA as for Jan. 06 2011) due to influenza

Birmingham parent's desperate vaccination plea after tot dies of swine flu

Birmingham parent's desperate vaccination plea after tot dies of swine flu

Jan 12 2011 By Amanda Crook
Lana Ameen

THE heartbroken parents of a three-year-old Birmingham girl killed by swine flu in less than 48 hours have released this harrowing picture of the tot fighting for her life in intensive care.

Gemma and Zana Ameen said their daughter Lana had no other health problems, yet died just two days after developing the deadly H1N1 virus on Christmas Eve.

Mrs Ameen, aged 28, has asked the Birmingham Mail to publish the tragic image of Lana in hospital to persuade the Government to make the swine flu vaccine available to all children ? so no other families will experience the devastation they are now suffering.

The nurse, who is 12 weeks? pregnant, also hopes it will serve as a warning to people who are eligible for an NHS vaccine to get themselves protected.

Mrs Ameen, from Quinton, said: ?We had never thought about swine flu ? then in less than 24 hours, our baby was practically dead.

<a href="http://s190.photobucket.com/albums/z27/prandot/?action=view&current=lana-ameen-590840449.jpg" target="_blank"><img src="http://i190.photobucket.com/albums/z27/prandot/lana-ameen-590840449.jpg" border="0" alt="Photobucket"></a>

http://www.birminghammail.net/news/...a-after-tot-dies-of-swine-flu-97319-27972550/

tetano · Jan 12, 2011

Re: UK: Reports of Approximately 73 Deaths and 800+ Patients in intensive care (50 deaths confirmed by HPA as for Jan. 06 2011) due to influenza

Re: UK: Reports of Approximately 73 Deaths and 800+ Patients in intensive care (50 deaths confirmed by HPA as for Jan. 06 2011) due to influenza

Aldeburgh: Mum of swine flu baby tells of anger over 13-hour wait for appointment

SUFFOLK’S out of hours doctors service came under fire last night from a concerned mother who was told she would have to travel for over an hour to get treatment for her baby son.

Melissa Sheppard, of Franklin Road, Aldeburgh, said that she was also left waiting a total of 13 hours over two days before she was offered an appointment.

The 34-year-old said she feared there could be a tragedy if no changes were made to the current out of hours set up, which is run by Harmoni.

Last night a spokesman for the company said they experienced their highest ever amount of calls over the festive period and the system and staff coped “admirably”.

He also pledged to investigate Mrs Sheppard’s experience to see if any lessons could be learnt.

The mum-of-three contacted Harmoni on Boxing Day after she became concerned for her 15-month-old son Connor, who was eventually diagnosed with swine flu and pneumonia.....

http://www.eadt.co.uk/news/aldeburg...er_over_13_hour_wait_for_appointment_1_771692

tetano · Jan 12, 2011

Re: UK: Reports of Approximately 73 Deaths and 800+ Patients in intensive care (50 deaths confirmed by HPA as for Jan. 06 2011) due to influenza

Re: UK: Reports of Approximately 73 Deaths and 800+ Patients in intensive care (50 deaths confirmed by HPA as for Jan. 06 2011) due to influenza

Tributes paid to latest victim of swine flu

THE swine flu epidemic has claimed a North East bus driver as its latest victim as concern grows that thousands of businesses could be hit by the flu outbreak.

Heartfelt tributes have been made to 40-year-old Peter Bladen who died in County Durham where he lived with his wife Sharon.

It is unknown how quickly the killer virus took hold of Mr Bladen?s system before his sudden death on January 4.

The home he shared with his family in Scardale Walk, Belmont, near Durham city, has been inundated with condolence cards and flowers from well-wishers paying tribute to the driver remembered for his brilliant sense of humour.

...

http://www.journallive.co.uk/north-...to-latest-victim-of-swine-flu-61634-27970832/

tetano · Jan 12, 2011

Re: UK: Reports of Approximately 73 Deaths and 800+ Patients in intensive care (50 deaths confirmed by HPA as for Jan. 06 2011) due to influenza

Re: UK: Reports of Approximately 73 Deaths and 800+ Patients in intensive care (50 deaths confirmed by HPA as for Jan. 06 2011) due to influenza

Anfield mum-of-two Tracey Louise Hulse dies from swine flu

<a href="http://s190.photobucket.com/albums/z27/prandot/?action=view&current=tracey-louise-hulse-family-746531722.jpg" target="_blank"><img src="http://i190.photobucket.com/albums/z27/prandot/tracey-louise-hulse-family-746531722.jpg" border="0" alt="Photobucket"></a>

TRIBUTES were today paid to a mum-of-two who died from swine flu.

Tracey Louise Hulse, 30, from Anfield, passed away after contracting the illness.

She lived with her boyfriend, Anthony Jervis, and her two daughters, Chloe, six, and Melissa, 11.

Ms Hulse suffered from asthma, and was rushed to the Royal Liverpool on December 16 when she started having trouble breathing, but died two days later.

She is the tenth victim of the illness in the region known to the ECHO.

http://www.liverpoolecho.co.uk/live...se-hulse-dies-from-swine-flu-100252-27971091/

tetano · Jan 12, 2011

Re: UK: Reports of Approximately 73 Deaths and 800+ Patients in intensive care (50 deaths confirmed by HPA as for Jan. 06 2011) due to influenza

Re: UK: Reports of Approximately 73 Deaths and 800+ Patients in intensive care (50 deaths confirmed by HPA as for Jan. 06 2011) due to influenza

Flu: No epidemic despite surge in cases says NHS Western Cheshire

A HUNDRED cases of influenza ? including swine flu ? have been diagnosed in the space of just three weeks in West Cheshire.

A surge in demand for the flu jab has seen some GP practices hit by shortages, while most chemists and pharmacies have run out of the vaccine.

People aged 15-44 have been most affected, with the Countess of Chester Hospital confirming some patients have needed critical care.

Between December 5 and Boxing Day the number of people suffering from flu shot up from 14 to 114.

However, NHS Western Cheshire says the figure remains well below those that would be seen in an epidemic.

http://www.ellesmereportpioneer.co....ses-says-nhs-western-cheshire-55940-27967827/

UK: 607 confirmed fatalities due to influenza

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