tetano
Editor, Senior Moderator
Sci Rep. 2017 Jan 4;7:39956. doi: 10.1038/srep39956.
[h=1]Universal and reusable virus deactivation system for respiratory protection.[/h] Quan FS[SUP]1[/SUP], Rubino I[SUP]2[/SUP], Lee SH[SUP]3[/SUP], Koch B[SUP]2[/SUP], Choi HJ[SUP]2[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Aerosolized pathogens are a leading cause of respiratory infection and transmission. Currently used protective measures pose potential risk of primary/secondary infection and transmission. Here, we report the development of a universal, reusable virus deactivation system by functionalization of the main fibrous filtration unit of surgical mask with sodium chloride salt. The salt coating on the fiber surface dissolves upon exposure to virus aerosols and recrystallizes during drying, destroying the pathogens. When tested with tightly sealed sides, salt-coated filters showed remarkably higher filtration efficiency than conventional mask filtration layer, and 100% survival rate was observed in mice infected with virus penetrated through salt-coated filters. Viruses captured on salt-coated filters exhibited rapid infectivity loss compared to gradual decrease on bare filters. Salt-coated filters proved highly effective in deactivating influenza viruses regardless of subtypes and following storage in harsh environmental conditions. Our results can be applied in obtaining a broad-spectrum, airborne pathogen prevention device in preparation for epidemic and pandemic of respiratory diseases.
PMID: 28051158 PMCID: PMC5209731 DOI: 10.1038/srep39956
[PubMed - in process] Free PMC Article
[h=1]Universal and reusable virus deactivation system for respiratory protection.[/h] Quan FS[SUP]1[/SUP], Rubino I[SUP]2[/SUP], Lee SH[SUP]3[/SUP], Koch B[SUP]2[/SUP], Choi HJ[SUP]2[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Aerosolized pathogens are a leading cause of respiratory infection and transmission. Currently used protective measures pose potential risk of primary/secondary infection and transmission. Here, we report the development of a universal, reusable virus deactivation system by functionalization of the main fibrous filtration unit of surgical mask with sodium chloride salt. The salt coating on the fiber surface dissolves upon exposure to virus aerosols and recrystallizes during drying, destroying the pathogens. When tested with tightly sealed sides, salt-coated filters showed remarkably higher filtration efficiency than conventional mask filtration layer, and 100% survival rate was observed in mice infected with virus penetrated through salt-coated filters. Viruses captured on salt-coated filters exhibited rapid infectivity loss compared to gradual decrease on bare filters. Salt-coated filters proved highly effective in deactivating influenza viruses regardless of subtypes and following storage in harsh environmental conditions. Our results can be applied in obtaining a broad-spectrum, airborne pathogen prevention device in preparation for epidemic and pandemic of respiratory diseases.
PMID: 28051158 PMCID: PMC5209731 DOI: 10.1038/srep39956
[PubMed - in process] Free PMC Article