tetano
Editor, Senior Moderator
J Infect Dis. 2019 Jan 31. doi: 10.1093/infdis/jiz004. [Epub ahead of print]
[h=1]Universal Influenza Vaccine Approaches Employing Full-Length or Head-only HA Proteins.[/h] Ross TM[SUP]1,[/SUP][SUP]2[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] There is currently an unmet need to develop an effective broadly-reactive or universal vaccine against influenza viruses capable of conferring protection against both seasonal and pre-pandemic strains. Currently, influenza vaccines elicit immune responses that are protective against antigenically similar viruses within a subtype. These vaccines elicit antibodies that target the surface viral glycoproteins hemagglutinin (HA) and neuraminidase (NA). If there is an antigenic mismatch between these proteins in the influenza vaccines and co-circulating influenza isolates, there is a decrease in the vaccine effectiveness in vaccinated people. Various novel influenza vaccine candidates are being evaluated in animal studies and clinical human trials. This article focuses on the advantages and potential short-comings of broadly-reactive or universal vaccine candidates based upon the HA globular head and the thoughts about using this antigen as the basis for future influenza vaccine strategies.
PMID: 30715379 DOI: 10.1093/infdis/jiz004
[h=1]Universal Influenza Vaccine Approaches Employing Full-Length or Head-only HA Proteins.[/h] Ross TM[SUP]1,[/SUP][SUP]2[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] There is currently an unmet need to develop an effective broadly-reactive or universal vaccine against influenza viruses capable of conferring protection against both seasonal and pre-pandemic strains. Currently, influenza vaccines elicit immune responses that are protective against antigenically similar viruses within a subtype. These vaccines elicit antibodies that target the surface viral glycoproteins hemagglutinin (HA) and neuraminidase (NA). If there is an antigenic mismatch between these proteins in the influenza vaccines and co-circulating influenza isolates, there is a decrease in the vaccine effectiveness in vaccinated people. Various novel influenza vaccine candidates are being evaluated in animal studies and clinical human trials. This article focuses on the advantages and potential short-comings of broadly-reactive or universal vaccine candidates based upon the HA globular head and the thoughts about using this antigen as the basis for future influenza vaccine strategies.
PMID: 30715379 DOI: 10.1093/infdis/jiz004