tetano
Editor, Senior Moderator
Vaccine
. 2020 Oct 9;S0264-410X(20)31303-7.
doi: 10.1016/j.vaccine.2020.10.013. Online ahead of print.
COVID-19 vaccine and boosted immunity: Nothing ad interim to do?
Luca Roncati[SUP] 1 [/SUP], Maria Vadal?[SUP] 2 [/SUP], Veronica Corazzari[SUP] 3 [/SUP], Beniamino Palmieri[SUP] 2 [/SUP]
Affiliations
Abstract
Today, Coronavirus Disease 2019 (COVID-19) is a global public health emergency and vaccination measures to counter its diffusion are deemed necessary. Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), the etiological agent of the disease, unleashes a T-helper 2 immune response in those patients requiring intensive care. Here, we illustrate the immunological mechanism to train the immune system towards a more effective and less symptomatic T-helper 1 immune response, to be exploited against SARS-CoV-2.
Keywords: Bacillus Calmette-Gu?rin (BCG); Coronavirus Disease 2019 (COVID-19); Corynebacterium parvum (C. parvum); Cutibacterium acnes (C. acnes); Hyaluronic acid; Propionibacterium acnes (P. acnes); Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2); T helper 1 (T(h)1); T helper 2 (T(h)2); Vaccine; cluster of differentiation 44 (CD44).
. 2020 Oct 9;S0264-410X(20)31303-7.
doi: 10.1016/j.vaccine.2020.10.013. Online ahead of print.
COVID-19 vaccine and boosted immunity: Nothing ad interim to do?
Luca Roncati[SUP] 1 [/SUP], Maria Vadal?[SUP] 2 [/SUP], Veronica Corazzari[SUP] 3 [/SUP], Beniamino Palmieri[SUP] 2 [/SUP]
Affiliations
- PMID: 33071005
- PMCID: PMC7546174
- DOI: 10.1016/j.vaccine.2020.10.013
Abstract
Today, Coronavirus Disease 2019 (COVID-19) is a global public health emergency and vaccination measures to counter its diffusion are deemed necessary. Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), the etiological agent of the disease, unleashes a T-helper 2 immune response in those patients requiring intensive care. Here, we illustrate the immunological mechanism to train the immune system towards a more effective and less symptomatic T-helper 1 immune response, to be exploited against SARS-CoV-2.
Keywords: Bacillus Calmette-Gu?rin (BCG); Coronavirus Disease 2019 (COVID-19); Corynebacterium parvum (C. parvum); Cutibacterium acnes (C. acnes); Hyaluronic acid; Propionibacterium acnes (P. acnes); Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2); T helper 1 (T(h)1); T helper 2 (T(h)2); Vaccine; cluster of differentiation 44 (CD44).