Giuseppe
Emeritus
Cross-reactive antibody responses to the 2009 A/H1N1v influenza virus in the Italian population in the pre-pandemic period. (Vaccine, abstract, edited)
[Source: US National Library of Medicine, (LINK). Edited.]
Vaccine. 2010 Mar 19. [Epub ahead of print]
Cross-reactive antibody responses to the 2009 A/H1N1v influenza virus in the Italian population in the pre-pandemic period.
Rizzo C, Rota MC, Bella A, Alfonsi V, Declich S, Caporali MG, Ranghiasci A, Lapini G, Piccirella S, Salmaso S, Montomoli E. - National Centre for Epidemiology, Surveillance and Health Promotion, Istituto Superiore di Sanit? Rome, Viale Regina Elena 299, Rome, Italy.
To assess in Italy the pre-pandemic susceptibility of the general population to the 2009 A/H1N1v influenza virus, 587 serum samples collected in 2004 were analyzed using haemagglutination-inhibition (HI), single-radial-haemolysis (SRH) and microneutralisation (MN) assays. Serum samples were stratified by age group, gender, and geographic area. Overall, using HI assay, the proportion of subjects showing antibodies cross-reacting with 2009 A/H1N1v virus at seroprotection level (>=1:40) was estimated to be 6.7%, 12.4%, and 22.4% in individuals born between 2004 and 1949, 1948 and 1939, 1938 and 1909, respectively. With a HI antibody titre of >=1:10, in the same birth cohort, the seroprotection levels were 13.5%, 19.2%, and 58.2%, respectively. The results suggest that the Italian population was not fully na?f to the current pandemic virus and that the possible previous exposure and immune response increases with age.
Copyright ? 2010. Published by Elsevier Ltd.
PMID: 20307592 [PubMed - as supplied by publisher]
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[Source: US National Library of Medicine, (LINK). Edited.]
Vaccine. 2010 Mar 19. [Epub ahead of print]
Cross-reactive antibody responses to the 2009 A/H1N1v influenza virus in the Italian population in the pre-pandemic period.
Rizzo C, Rota MC, Bella A, Alfonsi V, Declich S, Caporali MG, Ranghiasci A, Lapini G, Piccirella S, Salmaso S, Montomoli E. - National Centre for Epidemiology, Surveillance and Health Promotion, Istituto Superiore di Sanit? Rome, Viale Regina Elena 299, Rome, Italy.
To assess in Italy the pre-pandemic susceptibility of the general population to the 2009 A/H1N1v influenza virus, 587 serum samples collected in 2004 were analyzed using haemagglutination-inhibition (HI), single-radial-haemolysis (SRH) and microneutralisation (MN) assays. Serum samples were stratified by age group, gender, and geographic area. Overall, using HI assay, the proportion of subjects showing antibodies cross-reacting with 2009 A/H1N1v virus at seroprotection level (>=1:40) was estimated to be 6.7%, 12.4%, and 22.4% in individuals born between 2004 and 1949, 1948 and 1939, 1938 and 1909, respectively. With a HI antibody titre of >=1:10, in the same birth cohort, the seroprotection levels were 13.5%, 19.2%, and 58.2%, respectively. The results suggest that the Italian population was not fully na?f to the current pandemic virus and that the possible previous exposure and immune response increases with age.
Copyright ? 2010. Published by Elsevier Ltd.
PMID: 20307592 [PubMed - as supplied by publisher]
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