tetano
Editor, Senior Moderator
Vaccine
. 2023 Apr 1;S0264-410X(23)00349-3.
doi: 10.1016/j.vaccine.2023.03.055. Online ahead of print.
Efficacy of multivalent recombinant herpesvirus of turkey vaccines against high pathogenicity avian influenza, infectious bursal disease, and Newcastle disease viruses
Miria F Criado[SUP] 1 [/SUP], Aemro Kassa[SUP] 2 [/SUP], Kateri Bertran[SUP] 3 [/SUP], Jung-Hoon Kwon[SUP] 4 [/SUP], Mariana Sá E Silva[SUP] 5 [/SUP], Lindsay Killmaster[SUP] 6 [/SUP], Ted M Ross[SUP] 7 [/SUP], Teshome Mebatsion[SUP] 8 [/SUP], David E Swayne[SUP] 9 [/SUP]
Affiliations
Abstract
Vaccines are an essential tool for the control of viral infections in domestic animals. We generated recombinant vector herpesvirus of turkeys (vHVT) vaccines expressing computationally optimized broadly reactive antigen (COBRA) H5 of avian influenza virus (AIV) alone (vHVT-AI) or in combination with virus protein 2 (VP2) of infectious bursal disease virus (IBDV) (vHVT-IBD-AI) or fusion (F) protein of Newcastle disease virus (NDV) (vHVT-ND-AI). In vaccinated chickens, all three vHVT vaccines provided 90-100% clinical protection against three divergent clades of high pathogenicity avian influenza viruses (HPAIVs), and significantly decreased number of birds and oral viral shedding titers at 2 days post-challenge compared to shams. Four weeks after vaccination, most vaccinated birds had H5 hemagglutination inhibition antibody titers, which significantly increased post-challenge. The vHVT-IBD-AI and vHVT-ND-AI vaccines provided 100% clinical protection against IBDVs and NDV, respectively. Our findings demonstrate that multivalent HVT vector vaccines were efficacious for simultaneous control of HPAIV and other viral infections.
Keywords: HPAIV; HVT recombinant vector vaccine; IBDV; Multivalent vector; NDV; Poultry.
. 2023 Apr 1;S0264-410X(23)00349-3.
doi: 10.1016/j.vaccine.2023.03.055. Online ahead of print.
Efficacy of multivalent recombinant herpesvirus of turkey vaccines against high pathogenicity avian influenza, infectious bursal disease, and Newcastle disease viruses
Miria F Criado[SUP] 1 [/SUP], Aemro Kassa[SUP] 2 [/SUP], Kateri Bertran[SUP] 3 [/SUP], Jung-Hoon Kwon[SUP] 4 [/SUP], Mariana Sá E Silva[SUP] 5 [/SUP], Lindsay Killmaster[SUP] 6 [/SUP], Ted M Ross[SUP] 7 [/SUP], Teshome Mebatsion[SUP] 8 [/SUP], David E Swayne[SUP] 9 [/SUP]
Affiliations
- PMID: 37012117
- DOI: 10.1016/j.vaccine.2023.03.055
Abstract
Vaccines are an essential tool for the control of viral infections in domestic animals. We generated recombinant vector herpesvirus of turkeys (vHVT) vaccines expressing computationally optimized broadly reactive antigen (COBRA) H5 of avian influenza virus (AIV) alone (vHVT-AI) or in combination with virus protein 2 (VP2) of infectious bursal disease virus (IBDV) (vHVT-IBD-AI) or fusion (F) protein of Newcastle disease virus (NDV) (vHVT-ND-AI). In vaccinated chickens, all three vHVT vaccines provided 90-100% clinical protection against three divergent clades of high pathogenicity avian influenza viruses (HPAIVs), and significantly decreased number of birds and oral viral shedding titers at 2 days post-challenge compared to shams. Four weeks after vaccination, most vaccinated birds had H5 hemagglutination inhibition antibody titers, which significantly increased post-challenge. The vHVT-IBD-AI and vHVT-ND-AI vaccines provided 100% clinical protection against IBDVs and NDV, respectively. Our findings demonstrate that multivalent HVT vector vaccines were efficacious for simultaneous control of HPAIV and other viral infections.
Keywords: HPAIV; HVT recombinant vector vaccine; IBDV; Multivalent vector; NDV; Poultry.