tetano
Editor, Senior Moderator
Vaccine
. 2023 Dec 14:S0264-410X(23)01485-8.
doi: 10.1016/j.vaccine.2023.12.039. Online ahead of print. Influenza immune imprinting synergizes PEI-HA/CpG nanoparticle vaccine protection against heterosubtypic infection in mice
Chunhong Dong[SUP] 1 [/SUP], Yao Ma[SUP] 1 [/SUP], Wandi Zhu[SUP] 1 [/SUP], Ye Wang[SUP] 1 [/SUP], Joo Kim[SUP] 1 [/SUP], Lai Wei[SUP] 1 [/SUP], Harvinder Singh Gill[SUP] 2 [/SUP], Sang-Moo Kang[SUP] 1 [/SUP], Bao-Zhong Wang[SUP] 3 [/SUP]
Affiliations
The first influenza virus infection (imprinting) can lead to long-term immune memory and influence subsequent vaccinations and infections. Previously, we reported a polyethyleneimine (PEI)-Aichi hemagglutinin (HA)/CpG (PHC) nanoparticle with cross-protective potential against homologous and heterologous influenza strains. Here we studied how influenza immune imprinting influences the antibody responses to the PHC vaccination and the protection against heterosubtypic virus challenges. We found that pre-existing virus immunity can maintain or synergize the vaccine-induced antibody titers, depending on the imprinting virus HA phylogenetic group. The HA group 1 virus (PR8, H1N1)-imprinted mice displayed comparable antigen-specific antibody responses to those without imprinting post-PHC vaccination. In contrast, the group 2 virus (Phi, H3N2)-imprinted mice showed significantly more robust and balanced antibodies post-vaccination, conferring complete protection against body weight loss and lung inflammation upon heterosubtypic reassortant A/Shanghai/2/2013 (rSH, H7N9) virus challenge. Our findings suggest that influenza imprinting from the same HA phylogenetic group can synergize subsequent vaccination, conferring heterosubtypic protection.
Keywords: Heterosubtypic protection; Imprinting; Influenza vaccine; Nanoparticle vaccine.
. 2023 Dec 14:S0264-410X(23)01485-8.
doi: 10.1016/j.vaccine.2023.12.039. Online ahead of print. Influenza immune imprinting synergizes PEI-HA/CpG nanoparticle vaccine protection against heterosubtypic infection in mice
Chunhong Dong[SUP] 1 [/SUP], Yao Ma[SUP] 1 [/SUP], Wandi Zhu[SUP] 1 [/SUP], Ye Wang[SUP] 1 [/SUP], Joo Kim[SUP] 1 [/SUP], Lai Wei[SUP] 1 [/SUP], Harvinder Singh Gill[SUP] 2 [/SUP], Sang-Moo Kang[SUP] 1 [/SUP], Bao-Zhong Wang[SUP] 3 [/SUP]
Affiliations
- PMID: 38097456
- DOI: 10.1016/j.vaccine.2023.12.039
The first influenza virus infection (imprinting) can lead to long-term immune memory and influence subsequent vaccinations and infections. Previously, we reported a polyethyleneimine (PEI)-Aichi hemagglutinin (HA)/CpG (PHC) nanoparticle with cross-protective potential against homologous and heterologous influenza strains. Here we studied how influenza immune imprinting influences the antibody responses to the PHC vaccination and the protection against heterosubtypic virus challenges. We found that pre-existing virus immunity can maintain or synergize the vaccine-induced antibody titers, depending on the imprinting virus HA phylogenetic group. The HA group 1 virus (PR8, H1N1)-imprinted mice displayed comparable antigen-specific antibody responses to those without imprinting post-PHC vaccination. In contrast, the group 2 virus (Phi, H3N2)-imprinted mice showed significantly more robust and balanced antibodies post-vaccination, conferring complete protection against body weight loss and lung inflammation upon heterosubtypic reassortant A/Shanghai/2/2013 (rSH, H7N9) virus challenge. Our findings suggest that influenza imprinting from the same HA phylogenetic group can synergize subsequent vaccination, conferring heterosubtypic protection.
Keywords: Heterosubtypic protection; Imprinting; Influenza vaccine; Nanoparticle vaccine.