tetano
Editor, Senior Moderator
Vaccine
. 2023 Jun 27;S0264-410X(23)00775-2.
doi: 10.1016/j.vaccine.2023.06.072. Online ahead of print. Influenza vaccine effectiveness in preventing hospital encounters for laboratory-confirmed infection among Italian adults, 2022/23 season
Alexander Domnich[SUP] 1 [/SUP], Andrea Orsi[SUP] 2 [/SUP], Matilde Ogliastro[SUP] 3 [/SUP], Carlo-Simone Trombetta[SUP] 3 [/SUP], Marianna Scarpaleggia[SUP] 3 [/SUP], Federica Stefanelli[SUP] 4 [/SUP], Donatella Panatto[SUP] 5 [/SUP], Bianca Bruzzone[SUP] 4 [/SUP], Giancarlo Icardi[SUP] 2 [/SUP]
Affiliations
The effectiveness of seasonal influenza vaccination (SIV) varies from year to year. Interim estimates of vaccine effectiveness (VE) in outpatient settings have suggested that the 2022/23 northern hemisphere SIV was 54 % effective. The main goal of this study was to measure the 2022/23 SIV VE among Italian adults in a hospital setting. The study adopted a retrospective test-negative case-control design and was conducted in a large tertiary hospital (Genoa, Italy) between October 2022 and April 2023. Adult (≥18 years) patients accessing the hospital's Emergency Department for symptoms ascribable to an acute respiratory infection, for which a reverse-transcription real-time polymerase chain reaction test for the detection of influenza virus was prescribed, were potentially eligible. Of 33,692 referrals assessed, 487 patients were included in the study. A total of 13 % of patients were positive for influenza, most of which (63 %) belonged to the A(H3N2) subtype. SIV VE was 57 % (95 % CI: 11-81 %), 53 % (95 % CI: 2-80 %) and 38 % (95 % CI: -34-74 %) against any influenza, influenza A and A(H3N2), respectively. Although no cases caused by A(H1N1)pdm09 and B strains were observed among vaccinated individuals, VE estimates against the latter were imprecise, owing to their low detection rates. In conclusion, the 2022/23 SIV was moderately effective against hospital encounters for laboratory-confirmed influenza.
Keywords: Adults; Influenza; Influenza vaccine; Italy; Vaccine effectiveness.
. 2023 Jun 27;S0264-410X(23)00775-2.
doi: 10.1016/j.vaccine.2023.06.072. Online ahead of print. Influenza vaccine effectiveness in preventing hospital encounters for laboratory-confirmed infection among Italian adults, 2022/23 season
Alexander Domnich[SUP] 1 [/SUP], Andrea Orsi[SUP] 2 [/SUP], Matilde Ogliastro[SUP] 3 [/SUP], Carlo-Simone Trombetta[SUP] 3 [/SUP], Marianna Scarpaleggia[SUP] 3 [/SUP], Federica Stefanelli[SUP] 4 [/SUP], Donatella Panatto[SUP] 5 [/SUP], Bianca Bruzzone[SUP] 4 [/SUP], Giancarlo Icardi[SUP] 2 [/SUP]
Affiliations
- PMID: 37385889
- DOI: 10.1016/j.vaccine.2023.06.072
The effectiveness of seasonal influenza vaccination (SIV) varies from year to year. Interim estimates of vaccine effectiveness (VE) in outpatient settings have suggested that the 2022/23 northern hemisphere SIV was 54 % effective. The main goal of this study was to measure the 2022/23 SIV VE among Italian adults in a hospital setting. The study adopted a retrospective test-negative case-control design and was conducted in a large tertiary hospital (Genoa, Italy) between October 2022 and April 2023. Adult (≥18 years) patients accessing the hospital's Emergency Department for symptoms ascribable to an acute respiratory infection, for which a reverse-transcription real-time polymerase chain reaction test for the detection of influenza virus was prescribed, were potentially eligible. Of 33,692 referrals assessed, 487 patients were included in the study. A total of 13 % of patients were positive for influenza, most of which (63 %) belonged to the A(H3N2) subtype. SIV VE was 57 % (95 % CI: 11-81 %), 53 % (95 % CI: 2-80 %) and 38 % (95 % CI: -34-74 %) against any influenza, influenza A and A(H3N2), respectively. Although no cases caused by A(H1N1)pdm09 and B strains were observed among vaccinated individuals, VE estimates against the latter were imprecise, owing to their low detection rates. In conclusion, the 2022/23 SIV was moderately effective against hospital encounters for laboratory-confirmed influenza.
Keywords: Adults; Influenza; Influenza vaccine; Italy; Vaccine effectiveness.