tetano
Editor, Senior Moderator
Vaccine
. 2024 Oct 2;42(26):126381.
doi: 10.1016/j.vaccine.2024.126381. Online ahead of print. Real-world effectiveness of influenza vaccine over a decade during the 2011-2021 seasons-Implications of vaccine mismatch
Yu Jung Choi[SUP] 1 [/SUP], Joon Young Song[SUP] 1 [/SUP], Seong-Heon Wie[SUP] 2 [/SUP], Won Suk Choi[SUP] 3 [/SUP], Jacob Lee[SUP] 4 [/SUP], Jin-Soo Lee[SUP] 5 [/SUP], Young Keun Kim[SUP] 6 [/SUP], Shin Woo Kim[SUP] 7 [/SUP], Sun Hee Lee[SUP] 8 [/SUP], Kyung-Hwa Park[SUP] 9 [/SUP], Hye Won Jeong[SUP] 10 [/SUP], Jin Gu Yoon[SUP] 1 [/SUP], Hye Seong[SUP] 1 [/SUP], Eliel Nham[SUP] 1 [/SUP], Ji Yun Noh[SUP] 1 [/SUP], Hee Jin Cheong[SUP] 1 [/SUP], Woo Joo Kim[SUP] 11 [/SUP]
Affiliations
Background: Influenza imposes a significant healthcare burden in Korea, leading the government to initiate a national immunization program. Previous studies on vaccine effectiveness (VE) were limited to single-season estimation in Korea.
Methods: This multicenter prospective cohort study enrolled patients with influenza-like illnesses at 10 medical centers in Korea from 2011 to 2021. The demographic and clinical data were collected from questionnaire surveys and electronic medical records. Using a test-negative design, we aimed to investigate the effectiveness of a seasonal influenza vaccine for antigenic matching of the vaccine and circulating viral strains over 10 seasons.
Results: Overall, 5322 adults aged ≥65 years were enrolled. Only three (33.3 %) of nine seasons showed >70 % antigenic match between vaccine and circulating strains. Influenza VE was significantly variable by season, ranging from -46.9 % (95 %confidence interval [CI]: -127.6-5.2) in the 2011/12 season to 47.7 % (95 %CI: 22.6-64.7) in the 2016/17 season. A significant difference was observed in the VE depending on whether the vaccine strains matched with epidemic strains: 28.8 % (95 %CI: 8.8-44.8) in matched seasons versus -12.0 % (95 %CI: -30.0-3.7) in mismatched seasons. Across the study period, influenza-related hospitalizations were reduced by 13.6 % (95 %CI: 0.7-24.8) with vaccination. In a subgroup analysis, the VE against influenza-related hospitalization was 48.4 % (95 %CI 29.6-62.2) in A/H3N2 dominant seasons and 53.8 % (95 %CI: -73.4-87.7) in A/H1N1 dominant seasons, respectively.
Conclusion: Influenza vaccine mismatch was frequent over the study period, leading to negligibly low VE in mismatched seasons. Influenza vaccination reduces the risk of influenza-related hospitalizations.
Keywords: Hospitalization; Influenza; Influenza vaccine; Vaccine; Vaccine effectiveness.
. 2024 Oct 2;42(26):126381.
doi: 10.1016/j.vaccine.2024.126381. Online ahead of print. Real-world effectiveness of influenza vaccine over a decade during the 2011-2021 seasons-Implications of vaccine mismatch
Yu Jung Choi[SUP] 1 [/SUP], Joon Young Song[SUP] 1 [/SUP], Seong-Heon Wie[SUP] 2 [/SUP], Won Suk Choi[SUP] 3 [/SUP], Jacob Lee[SUP] 4 [/SUP], Jin-Soo Lee[SUP] 5 [/SUP], Young Keun Kim[SUP] 6 [/SUP], Shin Woo Kim[SUP] 7 [/SUP], Sun Hee Lee[SUP] 8 [/SUP], Kyung-Hwa Park[SUP] 9 [/SUP], Hye Won Jeong[SUP] 10 [/SUP], Jin Gu Yoon[SUP] 1 [/SUP], Hye Seong[SUP] 1 [/SUP], Eliel Nham[SUP] 1 [/SUP], Ji Yun Noh[SUP] 1 [/SUP], Hee Jin Cheong[SUP] 1 [/SUP], Woo Joo Kim[SUP] 11 [/SUP]
Affiliations
- PMID: 39362009
- DOI: 10.1016/j.vaccine.2024.126381
Background: Influenza imposes a significant healthcare burden in Korea, leading the government to initiate a national immunization program. Previous studies on vaccine effectiveness (VE) were limited to single-season estimation in Korea.
Methods: This multicenter prospective cohort study enrolled patients with influenza-like illnesses at 10 medical centers in Korea from 2011 to 2021. The demographic and clinical data were collected from questionnaire surveys and electronic medical records. Using a test-negative design, we aimed to investigate the effectiveness of a seasonal influenza vaccine for antigenic matching of the vaccine and circulating viral strains over 10 seasons.
Results: Overall, 5322 adults aged ≥65 years were enrolled. Only three (33.3 %) of nine seasons showed >70 % antigenic match between vaccine and circulating strains. Influenza VE was significantly variable by season, ranging from -46.9 % (95 %confidence interval [CI]: -127.6-5.2) in the 2011/12 season to 47.7 % (95 %CI: 22.6-64.7) in the 2016/17 season. A significant difference was observed in the VE depending on whether the vaccine strains matched with epidemic strains: 28.8 % (95 %CI: 8.8-44.8) in matched seasons versus -12.0 % (95 %CI: -30.0-3.7) in mismatched seasons. Across the study period, influenza-related hospitalizations were reduced by 13.6 % (95 %CI: 0.7-24.8) with vaccination. In a subgroup analysis, the VE against influenza-related hospitalization was 48.4 % (95 %CI 29.6-62.2) in A/H3N2 dominant seasons and 53.8 % (95 %CI: -73.4-87.7) in A/H1N1 dominant seasons, respectively.
Conclusion: Influenza vaccine mismatch was frequent over the study period, leading to negligibly low VE in mismatched seasons. Influenza vaccination reduces the risk of influenza-related hospitalizations.
Keywords: Hospitalization; Influenza; Influenza vaccine; Vaccine; Vaccine effectiveness.