tetano
Editor, Senior Moderator
Vaccine X
. 2023 Jun 5;14:100327.
doi: 10.1016/j.jvacx.2023.100327. eCollection 2023 Aug. High-dose influenza vaccine in older adults by age and seasonal characteristics: Systematic review and meta-analysis update
Jason K H Lee[SUP] 1 2 [/SUP], Gary K L Lam[SUP] 1 2 [/SUP], J Kevin Yin[SUP] 3 4 [/SUP], Matthew M Loiacono[SUP] 5 [/SUP], Sandrine I Samson[SUP] 6 [/SUP]
Affiliations
This updated systematic review and meta-analysis of randomized and observational studies published up to April 2023 assessed the relative performance of high-dose inactivated influenza vaccine (HD-IIV) and standard-dose influenza vaccines (SD-IIV) against influenza-associated outcomes in older adults (≥65 years). The analysis included studies conducted over 12 influenza seasons (2009/2010 to 2019/2020, 2021/2022), including over 45 million individuals aged ≥ 65 years, and showed that HD-IIV provided significantly better protection than SD-IIV against influenza-like illness and influenza-related hospitalizations, as well as cardiovascular, cardiorespiratory, and all-cause hospitalizations. Subgroup analyses showed HD-IIV consistently provided better protection than SD-IIV against influenza outcomes across the age range (65+, 75+ 85+ years), and regardless of the predominantly circulating influenza strain and vaccine antigenic match/mismatch. Randomized studies continue to drive high-quality evidence on the effectiveness of high-dose inactivated influenza vaccine relative to SD-IIV against severe influenza outcomes in adults aged ≥ 65 years, supported by observational data.
Keywords: Effectiveness; Elderly; High dose influenza vaccine; Hospitalization; Influenza; Meta-analysis.
. 2023 Jun 5;14:100327.
doi: 10.1016/j.jvacx.2023.100327. eCollection 2023 Aug. High-dose influenza vaccine in older adults by age and seasonal characteristics: Systematic review and meta-analysis update
Jason K H Lee[SUP] 1 2 [/SUP], Gary K L Lam[SUP] 1 2 [/SUP], J Kevin Yin[SUP] 3 4 [/SUP], Matthew M Loiacono[SUP] 5 [/SUP], Sandrine I Samson[SUP] 6 [/SUP]
Affiliations
- PMID: 37333054
- PMCID: PMC10276206
- DOI: 10.1016/j.jvacx.2023.100327
This updated systematic review and meta-analysis of randomized and observational studies published up to April 2023 assessed the relative performance of high-dose inactivated influenza vaccine (HD-IIV) and standard-dose influenza vaccines (SD-IIV) against influenza-associated outcomes in older adults (≥65 years). The analysis included studies conducted over 12 influenza seasons (2009/2010 to 2019/2020, 2021/2022), including over 45 million individuals aged ≥ 65 years, and showed that HD-IIV provided significantly better protection than SD-IIV against influenza-like illness and influenza-related hospitalizations, as well as cardiovascular, cardiorespiratory, and all-cause hospitalizations. Subgroup analyses showed HD-IIV consistently provided better protection than SD-IIV against influenza outcomes across the age range (65+, 75+ 85+ years), and regardless of the predominantly circulating influenza strain and vaccine antigenic match/mismatch. Randomized studies continue to drive high-quality evidence on the effectiveness of high-dose inactivated influenza vaccine relative to SD-IIV against severe influenza outcomes in adults aged ≥ 65 years, supported by observational data.
Keywords: Effectiveness; Elderly; High dose influenza vaccine; Hospitalization; Influenza; Meta-analysis.