tetano
Editor, Senior Moderator
Vaccines (Basel)
. 2021 Sep 29;9(10):1104.
doi: 10.3390/vaccines9101104.
A Systematic Review and Meta-Analysis of Seasonal Influenza Vaccination of Health Workers
Tingting Li[SUP] 1 [/SUP], Xiaoling Qi[SUP] 2 [/SUP], Qin Li[SUP] 1 [/SUP], Wenge Tang[SUP] 1 [/SUP], Kun Su[SUP] 1 [/SUP], Mengmeng Jia[SUP] 3 [/SUP], Weizhong Yang[SUP] 3 [/SUP], Yu Xia[SUP] 1 [/SUP], Yu Xiong[SUP] 1 [/SUP], Li Qi[SUP] 1 [/SUP], Luzhao Feng[SUP] 3 [/SUP]
Affiliations
Abstract
A systematic review and meta-analysis was conducted to estimate the pooled effect of influenza vaccinations for health workers (HWs). Nine databases were screened to identify randomized clinical trials and comparative observational studies that reported the effect of influenza vaccination among HWs. The risk ratio (RR), standardized mean difference, and 95% confidence interval (CI) were employed to study the effect size using fixed/random-effect models. Subgroup analyses and sensitivity analyses were conducted accordingly. Publication bias was examined. Sixteen studies (involving 7971 HWs from nine countries) were included after a comprehensive literature search. The combined RR regarding the incidence of laboratory-confirmed influenza was 0.36 (95% CI: 0.25 to 0.54), the incidence of influenza-like illness (ILI) was 0.69 (95% CI: 0.45 to 1.06), the absenteeism rate was 0.63 (95% CI: 0.46 to 0.86), and the integrated standardized mean difference of workdays lost was -0.18 (95% CI: -0.28 to -0.07) days/person. The subgroup analysis indicated that vaccination significantly decreases the incidence of laboratory-confirmed influenza in different countries, study populations, and average-age vaccinated groups. Influenza vaccinations could effectively reduce the incidence of laboratory-confirmed influenza, absenteeism rates, and workdays lost among HWs. It is advisable, therefore, to improve the coverage and increase the influenza vaccination count among HWs, which may benefit both workers and medical institutions.
Keywords: absenteeism rate; health workers; incidence of laboratory-confirmed influenza; influenza vaccination; meta-analysis.
. 2021 Sep 29;9(10):1104.
doi: 10.3390/vaccines9101104.
A Systematic Review and Meta-Analysis of Seasonal Influenza Vaccination of Health Workers
Tingting Li[SUP] 1 [/SUP], Xiaoling Qi[SUP] 2 [/SUP], Qin Li[SUP] 1 [/SUP], Wenge Tang[SUP] 1 [/SUP], Kun Su[SUP] 1 [/SUP], Mengmeng Jia[SUP] 3 [/SUP], Weizhong Yang[SUP] 3 [/SUP], Yu Xia[SUP] 1 [/SUP], Yu Xiong[SUP] 1 [/SUP], Li Qi[SUP] 1 [/SUP], Luzhao Feng[SUP] 3 [/SUP]
Affiliations
- PMID: 34696212
- DOI: 10.3390/vaccines9101104
Abstract
A systematic review and meta-analysis was conducted to estimate the pooled effect of influenza vaccinations for health workers (HWs). Nine databases were screened to identify randomized clinical trials and comparative observational studies that reported the effect of influenza vaccination among HWs. The risk ratio (RR), standardized mean difference, and 95% confidence interval (CI) were employed to study the effect size using fixed/random-effect models. Subgroup analyses and sensitivity analyses were conducted accordingly. Publication bias was examined. Sixteen studies (involving 7971 HWs from nine countries) were included after a comprehensive literature search. The combined RR regarding the incidence of laboratory-confirmed influenza was 0.36 (95% CI: 0.25 to 0.54), the incidence of influenza-like illness (ILI) was 0.69 (95% CI: 0.45 to 1.06), the absenteeism rate was 0.63 (95% CI: 0.46 to 0.86), and the integrated standardized mean difference of workdays lost was -0.18 (95% CI: -0.28 to -0.07) days/person. The subgroup analysis indicated that vaccination significantly decreases the incidence of laboratory-confirmed influenza in different countries, study populations, and average-age vaccinated groups. Influenza vaccinations could effectively reduce the incidence of laboratory-confirmed influenza, absenteeism rates, and workdays lost among HWs. It is advisable, therefore, to improve the coverage and increase the influenza vaccination count among HWs, which may benefit both workers and medical institutions.
Keywords: absenteeism rate; health workers; incidence of laboratory-confirmed influenza; influenza vaccination; meta-analysis.