tetano
Editor, Senior Moderator
Vet Rec
. 2023 Nov 27:e3616.
doi: 10.1002/vetr.3616. Online ahead of print. Vaccination of African penguins (Spheniscus demersus) against high-pathogenicity avian influenza
Laura Christl Roberts[SUP] 1 2 3 [/SUP], Darrell Abernethy[SUP] 3 4 [/SUP], David Gordon Roberts[SUP] 5 [/SUP], Katrin Ludynia[SUP] 5 6 [/SUP], Martha Magaretha O'Kennedy[SUP] 1 7 [/SUP], Celia Abolnik[SUP] 1 [/SUP]
Affiliations
Background: High-pathogenicity avian influenza (HPAI) has become a conservation threat to wild birds. Therefore, suitable vaccine technology and practical application methods require investigation.
Methods: Twenty-four African penguins (Spheniscus demersus) were vaccinated with either a conventional inactivated clade 2.3.4.4b H5N8 HPAI whole virus or a tobacco leaf-produced H5 haemagglutinin-based virus-like particle (VLP). Six birds received a second dose of the inactivated vaccine. Antibody responses were assessed and compared by employing haemagglutination inhibition tests.
Results: A second dose of inactivated vaccine was required to induce antibody titres above the level required to suppress virus shedding, while a single dose of VLP vaccine produced these levels by day 14, and one bird still had antibodies on day 430.
Limitations: Bacterial contamination of the VLP vaccine limited the monitoring period and sample size in that treatment group, and it was not possible to perform a challenge study with field virus.
Conclusion: VLP vaccines offer a more practical option than inactivated whole viruses, especially in logistically challenging situations involving wild birds.
. 2023 Nov 27:e3616.
doi: 10.1002/vetr.3616. Online ahead of print. Vaccination of African penguins (Spheniscus demersus) against high-pathogenicity avian influenza
Laura Christl Roberts[SUP] 1 2 3 [/SUP], Darrell Abernethy[SUP] 3 4 [/SUP], David Gordon Roberts[SUP] 5 [/SUP], Katrin Ludynia[SUP] 5 6 [/SUP], Martha Magaretha O'Kennedy[SUP] 1 7 [/SUP], Celia Abolnik[SUP] 1 [/SUP]
Affiliations
- PMID: 38012027
- DOI: 10.1002/vetr.3616
Background: High-pathogenicity avian influenza (HPAI) has become a conservation threat to wild birds. Therefore, suitable vaccine technology and practical application methods require investigation.
Methods: Twenty-four African penguins (Spheniscus demersus) were vaccinated with either a conventional inactivated clade 2.3.4.4b H5N8 HPAI whole virus or a tobacco leaf-produced H5 haemagglutinin-based virus-like particle (VLP). Six birds received a second dose of the inactivated vaccine. Antibody responses were assessed and compared by employing haemagglutination inhibition tests.
Results: A second dose of inactivated vaccine was required to induce antibody titres above the level required to suppress virus shedding, while a single dose of VLP vaccine produced these levels by day 14, and one bird still had antibodies on day 430.
Limitations: Bacterial contamination of the VLP vaccine limited the monitoring period and sample size in that treatment group, and it was not possible to perform a challenge study with field virus.
Conclusion: VLP vaccines offer a more practical option than inactivated whole viruses, especially in logistically challenging situations involving wild birds.