tetano
Editor, Senior Moderator
Influenza Other Respir Viruses. 2015 May 16. doi: 10.1111/irv.12326. [Epub ahead of print]
[h=1]Viral and atypical bacterial aetiologies of infection in hospitalised patients admitted with clinical suspicion of influenza in Thailand, Vietnam and Indonesia.[/h] Wertheim HF[SUP]1,[/SUP][SUP]2[/SUP], Nadjm B[SUP]1,[/SUP][SUP]2[/SUP], Thomas S[SUP]1[/SUP], Agustiningsih A[SUP]3[/SUP], Malik S[SUP]3[/SUP], Diep NN[SUP]1[/SUP], Vu TV[SUP]1[/SUP], Kinh NV[SUP]4[/SUP], Chau NV[SUP]5[/SUP], Liem NT[SUP]6[/SUP], Sinh TT[SUP]6[/SUP], Thuy BT[SUP]6[/SUP], Trung NV[SUP]4[/SUP], Hien TT[SUP]1,[/SUP][SUP]2[/SUP], Uyen NH[SUP]1[/SUP], Taylor W[SUP]7[/SUP], Khanh TH[SUP]8[/SUP], Tuan HM[SUP]9[/SUP], Chokephaibulkit K[SUP]10[/SUP], Farrar J[SUP]1,[/SUP][SUP]2[/SUP], Wolbers M[SUP]1,[/SUP][SUP]2[/SUP], de Jong MD[SUP]1,[/SUP][SUP]11[/SUP], van Doorn HR[SUP]1,[/SUP][SUP]2[/SUP], Puthavathana P[SUP]10[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] Influenza constitutes a leading cause of morbidity and mortality worldwide. There is limited information about the etiology of infection presenting clinically as influenza in hospitalized adults and children in Southeast Asia. Such data are important for future management of respiratory infections.
[h=4]OBJECTIVES:[/h] To describe the etiology of infection presenting clinically as influenza in those hospitalized in Southeast Asia METHODS: Respiratory specimens archived from July 2008 to June 2009 from patients hospitalised with suspected influenza from (Indonesia, Thailand and Vietnam were tested for respiratory viruses and atypical bacteria by polymerase chain reaction.
[h=4]RESULTS:[/h] A total of 1222 patients' samples were tested. 776/1222 (63.5%) patients were under the age of 5. Viruses detected included rhinoviruses in 229/1222 patients (18.7%), bocaviruses in 200/1222 (16.4%), respiratory syncytial viruses in 144 (11.8%), parainfluenzaviruses in 140 (11.5%; PIV1: 32; PIV2: 12; PIV3: 71;PIV4: 25), adenovirus in 102 (8.4%), influenza viruses in 93 (7.6%; influenza A: 77; influenza B: 16), coronaviruses in 23 (1.8%; OC43: 14; E229: 9). Bacterial pathogens were: Mycoplasma pneumoniae (n=33, 2.7%), Chlamydophila psittaci (n=2), C. pneumoniae (n=1), Bordetella pertussis (n=1), and Legionella pneumophila (n=2). Overall in-hospital case fatality rate was 29/1222 (2.4%).
[h=4]CONCLUSION:[/h] Respiratory viruses were the most commonly detected pathogens in patients hospitalized with a clinical suspicion of influenza. Rhinovirus was the most frequently detected virus, and M. pneumoniae the most common atypical bacterium. The low number of detected influenza viruses demonstrate a low benefit for empirical oseltamivir therapy, unless during an influenza outbreak. This article is protected by copyright. All rights reserved.
This article is protected by copyright. All rights reserved.
[h=4]KEYWORDS:[/h] RSV ; Hospitalization; Influenza; Mycoplasma pneumoniae; Respiratory Tract Infections; Rhinovirus
PMID: 25980749 [PubMed - as supplied by publisher]
[h=1]Viral and atypical bacterial aetiologies of infection in hospitalised patients admitted with clinical suspicion of influenza in Thailand, Vietnam and Indonesia.[/h] Wertheim HF[SUP]1,[/SUP][SUP]2[/SUP], Nadjm B[SUP]1,[/SUP][SUP]2[/SUP], Thomas S[SUP]1[/SUP], Agustiningsih A[SUP]3[/SUP], Malik S[SUP]3[/SUP], Diep NN[SUP]1[/SUP], Vu TV[SUP]1[/SUP], Kinh NV[SUP]4[/SUP], Chau NV[SUP]5[/SUP], Liem NT[SUP]6[/SUP], Sinh TT[SUP]6[/SUP], Thuy BT[SUP]6[/SUP], Trung NV[SUP]4[/SUP], Hien TT[SUP]1,[/SUP][SUP]2[/SUP], Uyen NH[SUP]1[/SUP], Taylor W[SUP]7[/SUP], Khanh TH[SUP]8[/SUP], Tuan HM[SUP]9[/SUP], Chokephaibulkit K[SUP]10[/SUP], Farrar J[SUP]1,[/SUP][SUP]2[/SUP], Wolbers M[SUP]1,[/SUP][SUP]2[/SUP], de Jong MD[SUP]1,[/SUP][SUP]11[/SUP], van Doorn HR[SUP]1,[/SUP][SUP]2[/SUP], Puthavathana P[SUP]10[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] Influenza constitutes a leading cause of morbidity and mortality worldwide. There is limited information about the etiology of infection presenting clinically as influenza in hospitalized adults and children in Southeast Asia. Such data are important for future management of respiratory infections.
[h=4]OBJECTIVES:[/h] To describe the etiology of infection presenting clinically as influenza in those hospitalized in Southeast Asia METHODS: Respiratory specimens archived from July 2008 to June 2009 from patients hospitalised with suspected influenza from (Indonesia, Thailand and Vietnam were tested for respiratory viruses and atypical bacteria by polymerase chain reaction.
[h=4]RESULTS:[/h] A total of 1222 patients' samples were tested. 776/1222 (63.5%) patients were under the age of 5. Viruses detected included rhinoviruses in 229/1222 patients (18.7%), bocaviruses in 200/1222 (16.4%), respiratory syncytial viruses in 144 (11.8%), parainfluenzaviruses in 140 (11.5%; PIV1: 32; PIV2: 12; PIV3: 71;PIV4: 25), adenovirus in 102 (8.4%), influenza viruses in 93 (7.6%; influenza A: 77; influenza B: 16), coronaviruses in 23 (1.8%; OC43: 14; E229: 9). Bacterial pathogens were: Mycoplasma pneumoniae (n=33, 2.7%), Chlamydophila psittaci (n=2), C. pneumoniae (n=1), Bordetella pertussis (n=1), and Legionella pneumophila (n=2). Overall in-hospital case fatality rate was 29/1222 (2.4%).
[h=4]CONCLUSION:[/h] Respiratory viruses were the most commonly detected pathogens in patients hospitalized with a clinical suspicion of influenza. Rhinovirus was the most frequently detected virus, and M. pneumoniae the most common atypical bacterium. The low number of detected influenza viruses demonstrate a low benefit for empirical oseltamivir therapy, unless during an influenza outbreak. This article is protected by copyright. All rights reserved.
This article is protected by copyright. All rights reserved.
[h=4]KEYWORDS:[/h] RSV ; Hospitalization; Influenza; Mycoplasma pneumoniae; Respiratory Tract Infections; Rhinovirus
PMID: 25980749 [PubMed - as supplied by publisher]