tetano
Editor, Senior Moderator
BMC Infect Dis. 2015 Nov 14;15(1):515. doi: 10.1186/s12879-015-1251-y.
[h=1]Viral and bacterial etiology of severe acute respiratory illness among children < 5 years of age without influenza in Niger.[/h] Lagare A[SUP]1[/SUP], Ma?nassara HB[SUP]2[/SUP], Issaka B[SUP]3[/SUP], Sidiki A[SUP]4[/SUP], Tempia S[SUP]5,[/SUP][SUP]6[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] Globally, pneumonia is the leading cause of morbidity and mortality in children, with the highest burden experienced in sub-Saharan Africa and Asia. However, there is a dearth of information on the etiology of severe acute respiratory illness (SARI) in Africa, including Niger.
[h=4]METHODS:[/h] We implemented a retrospective study as part of national influenza sentinel surveillance in Niger. We randomly selected a sample of nasopharyngeal specimens collected from children <5 years of age hospitalized with SARI from January 2010 through December 2012 in Niger. The samples were selected from individuals that tested negative by real-time reverse transcription polymerase chain reaction (rRT-PCR) for influenza A and B virus. The samples were analyzed using the Fast Track Diagnostic Respiratory Pathogens 21plus Kit (BioM?rieux, Luxemburg), which detects 23 respiratory pathogens including 18 viral and 5 bacterial agents.
[h=4]RESULTS:[/h] Among the 160 samples tested, 138 (86 %) tested positive for at least one viral or bacterial pathogen; in 22 (16 %) sample, only one pathogen was detected. We detected at least one respiratory virus in 126 (78 %) samples and at least one bacterium in 102 (64 %) samples. Respiratory syncytial virus (56/160; 35 %), rhinovirus (47/160; 29 %) and parainfluenza virus (39/160; 24 %) were the most common viral pathogens detected. Among bacterial pathogens, Streptococcus pneumoniae (90/160; 56 %) and Haemophilus influenzae type b (20/160; 12 %) predominated.
[h=4]CONCLUSIONS:[/h] The high prevalence of certain viral and bacterial pathogens among children <5 years of age with SARI highlights the need for continued and expanded surveillance in Niger.
PMID: 26567015 [PubMed - in process] PMCID: PMC4644278 Free PMC Article
[h=1]Viral and bacterial etiology of severe acute respiratory illness among children < 5 years of age without influenza in Niger.[/h] Lagare A[SUP]1[/SUP], Ma?nassara HB[SUP]2[/SUP], Issaka B[SUP]3[/SUP], Sidiki A[SUP]4[/SUP], Tempia S[SUP]5,[/SUP][SUP]6[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] Globally, pneumonia is the leading cause of morbidity and mortality in children, with the highest burden experienced in sub-Saharan Africa and Asia. However, there is a dearth of information on the etiology of severe acute respiratory illness (SARI) in Africa, including Niger.
[h=4]METHODS:[/h] We implemented a retrospective study as part of national influenza sentinel surveillance in Niger. We randomly selected a sample of nasopharyngeal specimens collected from children <5 years of age hospitalized with SARI from January 2010 through December 2012 in Niger. The samples were selected from individuals that tested negative by real-time reverse transcription polymerase chain reaction (rRT-PCR) for influenza A and B virus. The samples were analyzed using the Fast Track Diagnostic Respiratory Pathogens 21plus Kit (BioM?rieux, Luxemburg), which detects 23 respiratory pathogens including 18 viral and 5 bacterial agents.
[h=4]RESULTS:[/h] Among the 160 samples tested, 138 (86 %) tested positive for at least one viral or bacterial pathogen; in 22 (16 %) sample, only one pathogen was detected. We detected at least one respiratory virus in 126 (78 %) samples and at least one bacterium in 102 (64 %) samples. Respiratory syncytial virus (56/160; 35 %), rhinovirus (47/160; 29 %) and parainfluenza virus (39/160; 24 %) were the most common viral pathogens detected. Among bacterial pathogens, Streptococcus pneumoniae (90/160; 56 %) and Haemophilus influenzae type b (20/160; 12 %) predominated.
[h=4]CONCLUSIONS:[/h] The high prevalence of certain viral and bacterial pathogens among children <5 years of age with SARI highlights the need for continued and expanded surveillance in Niger.
PMID: 26567015 [PubMed - in process] PMCID: PMC4644278 Free PMC Article