tetano
Editor, Senior Moderator
PLoS One. 2015 Sep 2;10(9):e0136526. doi: 10.1371/journal.pone.0136526. eCollection 2015.
[h=1]Viral Co-Infections in Pediatric Patients Hospitalized with Lower Tract Acute Respiratory Infections.[/h] Cebey-L?pez M[SUP]1[/SUP], Herberg J[SUP]2[/SUP], Pardo-Seco J[SUP]3[/SUP], G?mez-Carballa A[SUP]3[/SUP], Martin?n-Torres N[SUP]1[/SUP], Salas A[SUP]4[/SUP], Martin?n-S?nchez JM[SUP]1[/SUP], Gormley S[SUP]2[/SUP], Sumner E[SUP]5[/SUP], Fink C[SUP]5[/SUP], Martin?n-Torres F[SUP]1[/SUP]; GENDRES network.
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] Molecular techniques can often reveal a broader range of pathogens in respiratory infections. We aim to investigate the prevalence and age pattern of viral co-infection in children hospitalized with lower tract acute respiratory infection (LT-ARI), using molecular techniques.
[h=4]METHODS:[/h] A nested polymerase chain reaction approach was used to detect Influenza (A, B), metapneumovirus, respiratory syncytial virus (RSV), parainfluenza (1-4), rhinovirus, adenovirus (A-F), bocavirus and coronaviruses (NL63, 229E, OC43) in respiratory samples of children with acute respiratory infection prospectively admitted to any of the GENDRES network hospitals between 2011-2013. The results were corroborated in an independent cohort collected in the UK.
[h=4]RESULTS:[/h] A total of 204 and 97 nasopharyngeal samples were collected in the GENDRES and UK cohorts, respectively. In both cohorts, RSV was the most frequent pathogen (52.9% and 36.1% of the cohorts, respectively). Co-infection with multiple viruses was found in 92 samples (45.1%) and 29 samples (29.9%), respectively; this was most frequent in the 12-24 months age group. The most frequently observed co-infection patterns were RSV-Rhinovirus (23 patients, 11.3%, GENDRES cohort) and RSV-bocavirus / bocavirus-influenza (5 patients, 5.2%, UK cohort).
[h=4]CONCLUSION:[/h] The presence of more than one virus in pediatric patients admitted to hospital with LT-ARI is very frequent and seems to peak at 12-24 months of age. The clinical significance of these findings is unclear but should warrant further analysis.
PMID: 26332375 [PubMed - in process] Free full text
[h=1]Viral Co-Infections in Pediatric Patients Hospitalized with Lower Tract Acute Respiratory Infections.[/h] Cebey-L?pez M[SUP]1[/SUP], Herberg J[SUP]2[/SUP], Pardo-Seco J[SUP]3[/SUP], G?mez-Carballa A[SUP]3[/SUP], Martin?n-Torres N[SUP]1[/SUP], Salas A[SUP]4[/SUP], Martin?n-S?nchez JM[SUP]1[/SUP], Gormley S[SUP]2[/SUP], Sumner E[SUP]5[/SUP], Fink C[SUP]5[/SUP], Martin?n-Torres F[SUP]1[/SUP]; GENDRES network.
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] Molecular techniques can often reveal a broader range of pathogens in respiratory infections. We aim to investigate the prevalence and age pattern of viral co-infection in children hospitalized with lower tract acute respiratory infection (LT-ARI), using molecular techniques.
[h=4]METHODS:[/h] A nested polymerase chain reaction approach was used to detect Influenza (A, B), metapneumovirus, respiratory syncytial virus (RSV), parainfluenza (1-4), rhinovirus, adenovirus (A-F), bocavirus and coronaviruses (NL63, 229E, OC43) in respiratory samples of children with acute respiratory infection prospectively admitted to any of the GENDRES network hospitals between 2011-2013. The results were corroborated in an independent cohort collected in the UK.
[h=4]RESULTS:[/h] A total of 204 and 97 nasopharyngeal samples were collected in the GENDRES and UK cohorts, respectively. In both cohorts, RSV was the most frequent pathogen (52.9% and 36.1% of the cohorts, respectively). Co-infection with multiple viruses was found in 92 samples (45.1%) and 29 samples (29.9%), respectively; this was most frequent in the 12-24 months age group. The most frequently observed co-infection patterns were RSV-Rhinovirus (23 patients, 11.3%, GENDRES cohort) and RSV-bocavirus / bocavirus-influenza (5 patients, 5.2%, UK cohort).
[h=4]CONCLUSION:[/h] The presence of more than one virus in pediatric patients admitted to hospital with LT-ARI is very frequent and seems to peak at 12-24 months of age. The clinical significance of these findings is unclear but should warrant further analysis.
PMID: 26332375 [PubMed - in process] Free full text