tetano
Editor, Senior Moderator
Pediatr Infect Dis J. 2012 Nov 28. [Epub ahead of print]
Viral Etiology of Acute Respiratory Infections in Hospitalized and Outpatient Children in Buenos Aires, Argentina.
Marcone DN, Ellis A, Videla C, Ekstrom J, Ricarte C, Carballal G, Vidaurreta SM, Echavarr?a M.
Source
* Virology Unit and Clinical Virology Laboratory, Centro de Educaci?n M?dica e Investigaciones Cl?nicas (CEMIC) University Hospital. Av. Galv?n 4102, Buenos Aires, Argentina. ? Department of Pediatrics, Centro de Educaci?n M?dica e Investigaciones Cl?nicas (CEMIC) University Hospital. Av. Galv?n 4102, Buenos Aires, Argentina. ? Department of Pediatrics, Mater Dei Hospital. San Mart?n de Tours 2952, Buenos Aires, Argentina.
Abstract
OBJECTIVES:: To determine and compare the viral frequency, seasonality, and clinical-demographic features in two groups of children (hospitalized vs. outpatients) with acute respiratory infections (ARI). MATERIAL AND METHODS:: A cross sectional, descriptive study was performed from 2008 to 2010, in 620 children < 6 years of age with ARI. Respiratory samples were studied for classical respiratory viruses by immunofluorescence (IF) and for human rhinoviruses (HRV) by real time RT-PCR. Clinical and demographic data were recorded. RESULTS:: Viral detection by IF was 48% in 434 inpatients and 37% in 186 outpatients. Viral diagnosis increased to 83% and 62%, respectively, when testing for HRV. HRV (41%) and respiratory syncytial virus (RSV) (27%) were most common viruses identified, followed by metapneumovirus (9%), influenza A and parainfluenza (3%), adenovirus and influenza B (2%). HRV frequency was significantly higher in hospitalized patients (47%) than in outpatients (27%) (p<0.001). Coinfection was detected in 12% of hospitalized and 4% of outpatients (p<0.031). HRV and adenovirus circulated throughout the entire year. RSV, influenza A and B predominated in winter, while metapneumovirus and parainfluenza predominated in spring. Of 362 patients with bronchiolitis, 84% had a virus identified; HRV (42%) and RSV (38%) were predominant. Of 77 patients with pneumonia, 84% had a virus detected with HRV (43%) and RSV (29%) predominating. CONCLUSIONS:: HRV were significant pathogens associated with bronchiolitis and pneumonia, especially in hospitalized patients. Both, HRV and coinfections, were risk factors for hospitalization. These findings support the importance of including HRV detection in children with ARI.
PMID:
23190781
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/23190781
Viral Etiology of Acute Respiratory Infections in Hospitalized and Outpatient Children in Buenos Aires, Argentina.
Marcone DN, Ellis A, Videla C, Ekstrom J, Ricarte C, Carballal G, Vidaurreta SM, Echavarr?a M.
Source
* Virology Unit and Clinical Virology Laboratory, Centro de Educaci?n M?dica e Investigaciones Cl?nicas (CEMIC) University Hospital. Av. Galv?n 4102, Buenos Aires, Argentina. ? Department of Pediatrics, Centro de Educaci?n M?dica e Investigaciones Cl?nicas (CEMIC) University Hospital. Av. Galv?n 4102, Buenos Aires, Argentina. ? Department of Pediatrics, Mater Dei Hospital. San Mart?n de Tours 2952, Buenos Aires, Argentina.
Abstract
OBJECTIVES:: To determine and compare the viral frequency, seasonality, and clinical-demographic features in two groups of children (hospitalized vs. outpatients) with acute respiratory infections (ARI). MATERIAL AND METHODS:: A cross sectional, descriptive study was performed from 2008 to 2010, in 620 children < 6 years of age with ARI. Respiratory samples were studied for classical respiratory viruses by immunofluorescence (IF) and for human rhinoviruses (HRV) by real time RT-PCR. Clinical and demographic data were recorded. RESULTS:: Viral detection by IF was 48% in 434 inpatients and 37% in 186 outpatients. Viral diagnosis increased to 83% and 62%, respectively, when testing for HRV. HRV (41%) and respiratory syncytial virus (RSV) (27%) were most common viruses identified, followed by metapneumovirus (9%), influenza A and parainfluenza (3%), adenovirus and influenza B (2%). HRV frequency was significantly higher in hospitalized patients (47%) than in outpatients (27%) (p<0.001). Coinfection was detected in 12% of hospitalized and 4% of outpatients (p<0.031). HRV and adenovirus circulated throughout the entire year. RSV, influenza A and B predominated in winter, while metapneumovirus and parainfluenza predominated in spring. Of 362 patients with bronchiolitis, 84% had a virus identified; HRV (42%) and RSV (38%) were predominant. Of 77 patients with pneumonia, 84% had a virus detected with HRV (43%) and RSV (29%) predominating. CONCLUSIONS:: HRV were significant pathogens associated with bronchiolitis and pneumonia, especially in hospitalized patients. Both, HRV and coinfections, were risk factors for hospitalization. These findings support the importance of including HRV detection in children with ARI.
PMID:
23190781
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/23190781