tetano
Editor, Senior Moderator
Rev Peru Med Exp Salud Publica. 2019 Apr-Jun;36(2):231-238. doi: 10.17843/rpmesp.2019.362.4081. Epub 2019 Aug 22.
[h=1][Viral etiology of severe acute respiratory infections in a pediatric intensive care unit].[/h] [Article in Spanish; Abstract available in Spanish from the publisher]
Becerra M[SUP]1[/SUP], Fiestas V[SUP]2[/SUP], Tantale?n J[SUP]1,[/SUP][SUP]3[/SUP], Mallma G[SUP]1[/SUP], Alvarado M[SUP]1[/SUP], Guti?rrez V[SUP]2[/SUP], Huaringa M[SUP]2[/SUP], Rojas N[SUP]2[/SUP].
[h=3]Author information[/h] 1 Unidad de Cuidados Intensivos Pedi?tricos, Instituto Nacional de Salud del Ni?o. Lima, Per?. 2 Centro Nacional de Salud P?blica, Instituto Nacional de Salud. Lima, Per?. 3 Universidad Nacional Federico Villarreal. Lima, Per?.
[h=3]Abstract[/h] in English, Spanish
[h=4]OBJECTIVES.:[/h] To identify the main viral etiological agents in patients with severe acute respiratory infection (SARI) hospitalized in a Pediatric Intensive Care Unit (PICU) and to analyze their clinical characteristics.
[h=4]MATERIALS AND METHODS.:[/h] Prospective longitudinal study in children under five years of age hospitalized due to SARI at the PICU of t Instituto Nacional de Salud del Ni?o (National Children?s Hospital) in Lima, Peru. Real-time direct immunofluorescence and RT-PCR tests were performed for the diagnosis of respiratory viruses on tracheal aspirate or nasopharyngeal swab samples.
[h=4]RESULTS.:[/h] We included 117 patients. Median age was four months, 66% had comorbidity and 91% required mechanical ventilation. Respiratory virus monoinfection was identified in 47% and viral co-infection in 2.6%, with the respiratory syncytial virus subtype A (RSV-A) being the most frequent. The median length of hospitalization was 21 days and 20 (17%) patients died. An association was found between a history of chronic lung disease and RSV-A infection (p=0.045), and between Down syndrome and influenza A virus infection (p=0.01). After controlling for potential confounders, congenital heart disease (RR 3.1; 95% CI: 1.3-5.8, p=0.002) and nosocomial infection (RR 2.6; 95% CI: 1.0-5.3, p=0.01) were found to increase the risk of death in patients with SARI.
[h=4]CONCLUSIONS.:[/h] RSV-A was the most common viral etiology in children under five hospitalized by SARI at the PICU. No association was found between viral infection and patient survival.
PMID: 31460634 DOI: 10.17843/rpmesp.2019.362.4081
[h=1][Viral etiology of severe acute respiratory infections in a pediatric intensive care unit].[/h] [Article in Spanish; Abstract available in Spanish from the publisher]
Becerra M[SUP]1[/SUP], Fiestas V[SUP]2[/SUP], Tantale?n J[SUP]1,[/SUP][SUP]3[/SUP], Mallma G[SUP]1[/SUP], Alvarado M[SUP]1[/SUP], Guti?rrez V[SUP]2[/SUP], Huaringa M[SUP]2[/SUP], Rojas N[SUP]2[/SUP].
[h=3]Author information[/h] 1 Unidad de Cuidados Intensivos Pedi?tricos, Instituto Nacional de Salud del Ni?o. Lima, Per?. 2 Centro Nacional de Salud P?blica, Instituto Nacional de Salud. Lima, Per?. 3 Universidad Nacional Federico Villarreal. Lima, Per?.
[h=3]Abstract[/h] in English, Spanish
[h=4]OBJECTIVES.:[/h] To identify the main viral etiological agents in patients with severe acute respiratory infection (SARI) hospitalized in a Pediatric Intensive Care Unit (PICU) and to analyze their clinical characteristics.
[h=4]MATERIALS AND METHODS.:[/h] Prospective longitudinal study in children under five years of age hospitalized due to SARI at the PICU of t Instituto Nacional de Salud del Ni?o (National Children?s Hospital) in Lima, Peru. Real-time direct immunofluorescence and RT-PCR tests were performed for the diagnosis of respiratory viruses on tracheal aspirate or nasopharyngeal swab samples.
[h=4]RESULTS.:[/h] We included 117 patients. Median age was four months, 66% had comorbidity and 91% required mechanical ventilation. Respiratory virus monoinfection was identified in 47% and viral co-infection in 2.6%, with the respiratory syncytial virus subtype A (RSV-A) being the most frequent. The median length of hospitalization was 21 days and 20 (17%) patients died. An association was found between a history of chronic lung disease and RSV-A infection (p=0.045), and between Down syndrome and influenza A virus infection (p=0.01). After controlling for potential confounders, congenital heart disease (RR 3.1; 95% CI: 1.3-5.8, p=0.002) and nosocomial infection (RR 2.6; 95% CI: 1.0-5.3, p=0.01) were found to increase the risk of death in patients with SARI.
[h=4]CONCLUSIONS.:[/h] RSV-A was the most common viral etiology in children under five hospitalized by SARI at the PICU. No association was found between viral infection and patient survival.
PMID: 31460634 DOI: 10.17843/rpmesp.2019.362.4081