tetano
Editor, Senior Moderator
Influenza Other Respir Viruses. 2016 Mar 25. doi: 10.1111/irv.12391. [Epub ahead of print]
[h=1]Viral etiology of Severe Acute Respiratory Infections in hospitalized children in Cameroon, 2011-2013.[/h] Kenmoe S[SUP]1[/SUP], Tchendjou P[SUP]1[/SUP], Vernet MA[SUP]1[/SUP], Moyo-Tetang S[SUP]2[/SUP], Mossus T[SUP]1[/SUP], Njankouo-Ripa M[SUP]1[/SUP], Kenne A[SUP]1[/SUP], Penlap Mbeng V[SUP]3[/SUP], Vabret A[SUP]4[/SUP], Njouom R[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] Severe Acute Respiratory Illness (SARI) is recognized as an important cause of morbidity, mortality, and hospitalization among children in developing countries. Little is known, however, in tropical countries like Cameroon about the cause and seasonality of respiratory infections, especially in hospitalized settings.
[h=4]OBJECTIVES:[/h] Our study investigates the viral etiology and seasonality of SARI in hospitalized children in Yaounde, Cameroon.
[h=4]METHODS:[/h] Prospective clinic surveillance was conducted to identify hospitalized children ≤ 15 years of age presenting with respiratory symptoms ≤ 5 days duration. Demographics and clinical data, and respiratory specimens were collected. Nasopharyngeal samples were tested for 17 respiratory viruses using a multiplex polymerase chain reaction. The viral distribution and demographic data were statistically analyzed.
[h=4]RESULTS:[/h] From September 2011 through September 2013, 347 children ≤ 15 years of age were enrolled. At least 1 virus was identified in each of 65.4% children, of which 29.5% were coinfections; 27.3% were positive for human Adenovirus (hAdV), 13.2% for human Respiratory Syncytial Virus (hRSV), 11.5% for Rhinovirus/Enterovirus (RV/EV), 10.6% for human Bocavirus (hBoV), 9.8% for Influenza Virus (Inf), 6.6% for human Parainfluenzavirus (hPIV), 5.7% for human Coronavirus (hCoV), and 2.3% for human Metapneumovirus (hMPV). While hRSV showed seasonal patterns, hAdV and RV/EV were detected throughout the year and no evident temporal patterns were observed for the remaining viruses.
[h=4]CONCLUSION:[/h] Respiratory viruses were associated with a high burden of hospitalizations among children in Cameroon. Nevertheless, additional studies evaluating asymptomatic Cameroonian children will be important in understanding the relationship between viral carriage and disease. This article is protected by copyright. All rights reserved.
This article is protected by copyright. All rights reserved.
[h=4]KEYWORDS:[/h] Africa; Cameroon; Etiology; SARI; Virus
PMID: 27012372 [PubMed - as supplied by publisher] Free full text
[h=1]Viral etiology of Severe Acute Respiratory Infections in hospitalized children in Cameroon, 2011-2013.[/h] Kenmoe S[SUP]1[/SUP], Tchendjou P[SUP]1[/SUP], Vernet MA[SUP]1[/SUP], Moyo-Tetang S[SUP]2[/SUP], Mossus T[SUP]1[/SUP], Njankouo-Ripa M[SUP]1[/SUP], Kenne A[SUP]1[/SUP], Penlap Mbeng V[SUP]3[/SUP], Vabret A[SUP]4[/SUP], Njouom R[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] Severe Acute Respiratory Illness (SARI) is recognized as an important cause of morbidity, mortality, and hospitalization among children in developing countries. Little is known, however, in tropical countries like Cameroon about the cause and seasonality of respiratory infections, especially in hospitalized settings.
[h=4]OBJECTIVES:[/h] Our study investigates the viral etiology and seasonality of SARI in hospitalized children in Yaounde, Cameroon.
[h=4]METHODS:[/h] Prospective clinic surveillance was conducted to identify hospitalized children ≤ 15 years of age presenting with respiratory symptoms ≤ 5 days duration. Demographics and clinical data, and respiratory specimens were collected. Nasopharyngeal samples were tested for 17 respiratory viruses using a multiplex polymerase chain reaction. The viral distribution and demographic data were statistically analyzed.
[h=4]RESULTS:[/h] From September 2011 through September 2013, 347 children ≤ 15 years of age were enrolled. At least 1 virus was identified in each of 65.4% children, of which 29.5% were coinfections; 27.3% were positive for human Adenovirus (hAdV), 13.2% for human Respiratory Syncytial Virus (hRSV), 11.5% for Rhinovirus/Enterovirus (RV/EV), 10.6% for human Bocavirus (hBoV), 9.8% for Influenza Virus (Inf), 6.6% for human Parainfluenzavirus (hPIV), 5.7% for human Coronavirus (hCoV), and 2.3% for human Metapneumovirus (hMPV). While hRSV showed seasonal patterns, hAdV and RV/EV were detected throughout the year and no evident temporal patterns were observed for the remaining viruses.
[h=4]CONCLUSION:[/h] Respiratory viruses were associated with a high burden of hospitalizations among children in Cameroon. Nevertheless, additional studies evaluating asymptomatic Cameroonian children will be important in understanding the relationship between viral carriage and disease. This article is protected by copyright. All rights reserved.
This article is protected by copyright. All rights reserved.
[h=4]KEYWORDS:[/h] Africa; Cameroon; Etiology; SARI; Virus
PMID: 27012372 [PubMed - as supplied by publisher] Free full text