tetano
Editor, Senior Moderator
Launes, C., Garcia-Garcia, J. J., Jordan, I., Selva, L., Rello, J. and Mu?oz-Almagro, C. (2012), Viral load at diagnosis and influenza A H1N1 (2009) disease severity in children. Influenza and Other Respiratory Viruses. doi: 10.1111/j.1750-2659.2012.00383.x
Author Information
1
Infectious Diseases Unit, Department of Pediatrics, Hospital Sant Joan de D?u, University of Barcelona, Barcelona, Spain.
2
Pediatric Intensive Care Unit, Hospital Sant Joan de D?u, University of Barcelona, Barcelona, Spain.
3
Department of Molecular Microbiology, Hospital Sant Joan de D?u, University of Barcelona, Barcelona, Spain.
4
Critical Care Department, Hospital Vall d?Hebron, Autonomous University of Barcelona, CIBERES, Barcelona, Spain.
5
Department of Molecular Microbiology, Hospital Sant Joan de D?u, University of Barcelona, Barcelona, Spain.
*Cristian Launes, Pediatric Infectious Diseases Unit, Hospital Sant Joan de D?u, Passeig Sant Joan de D?u no2, ES-08150 Esplugues de Llobregat, Barcelona, Spain. E-mail: claunes@hsjdbcn.org
Publication History
Article first published online: 24 MAY 2012
Accepted 23 April 2012. Published Online 24 May 2012.
To assess viral load at diagnosis (VLAD) as a biomarker of novel influenza disease severity, epidemiologic and clinical data of admitted patients <18 years old with Influenza A H1N1 (2009) infection and respiratory symptoms were prospectively collected in a single pediatric tertiary hospital, from weeks 30?51 of 2009. Seventy patients were included. VLAD in children who had symptoms for ≥5 days was an accurate parameter distinguishing the patients who required mechanical ventilation (MV) from those who did not required it (area under the ROC curve: 0?73; P = 0?03). Having <4?5 log10 copies/ml with ≥5 days of symptoms was associated with a lower risk of requiring MV.
http://onlinelibrary.wiley.com/doi/10.1111/j.1750-2659.2012.00383.x/abstract
Author Information
1
Infectious Diseases Unit, Department of Pediatrics, Hospital Sant Joan de D?u, University of Barcelona, Barcelona, Spain.
2
Pediatric Intensive Care Unit, Hospital Sant Joan de D?u, University of Barcelona, Barcelona, Spain.
3
Department of Molecular Microbiology, Hospital Sant Joan de D?u, University of Barcelona, Barcelona, Spain.
4
Critical Care Department, Hospital Vall d?Hebron, Autonomous University of Barcelona, CIBERES, Barcelona, Spain.
5
Department of Molecular Microbiology, Hospital Sant Joan de D?u, University of Barcelona, Barcelona, Spain.
*Cristian Launes, Pediatric Infectious Diseases Unit, Hospital Sant Joan de D?u, Passeig Sant Joan de D?u no2, ES-08150 Esplugues de Llobregat, Barcelona, Spain. E-mail: claunes@hsjdbcn.org
Publication History
Article first published online: 24 MAY 2012
Accepted 23 April 2012. Published Online 24 May 2012.
To assess viral load at diagnosis (VLAD) as a biomarker of novel influenza disease severity, epidemiologic and clinical data of admitted patients <18 years old with Influenza A H1N1 (2009) infection and respiratory symptoms were prospectively collected in a single pediatric tertiary hospital, from weeks 30?51 of 2009. Seventy patients were included. VLAD in children who had symptoms for ≥5 days was an accurate parameter distinguishing the patients who required mechanical ventilation (MV) from those who did not required it (area under the ROC curve: 0?73; P = 0?03). Having <4?5 log10 copies/ml with ≥5 days of symptoms was associated with a lower risk of requiring MV.
http://onlinelibrary.wiley.com/doi/10.1111/j.1750-2659.2012.00383.x/abstract