tetano
Editor, Senior Moderator
Braz J Microbiol. 2018 Dec 5. doi: 10.1007/s42770-018-0033-2. [Epub ahead of print]
[h=1]Viral pathogens associated with acute lower respiratory tract infections in children younger than 5 years of age in Bulgaria.[/h] Korsun N[SUP]1[/SUP], Angelova S[SUP]2[/SUP], Trifonova I[SUP]2[/SUP], Georgieva I[SUP]2[/SUP], Voleva S[SUP]2[/SUP], Tzotcheva I[SUP]3[/SUP], Mileva S[SUP]2,[/SUP][SUP]3[/SUP], Ivanov I[SUP]4[/SUP], Tcherveniakova T[SUP]4[/SUP], Perenovska P[SUP]3[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Acute lower respiratory infections (ALRIs) are a leading cause of morbidity and hospital admissions in children. This study aimed to determine the viral etiology of these infections in children aged < 5 years during three successive epidemic seasons in Bulgaria. Nasopharyngeal and throat specimens were collected from children with bronchiolitis and pneumonia during the 2015/2016, 2016/2017, and 2017/2018 seasons. The viral etiology was determined by individual real-time PCR assays against 11 respiratory viruses. Of the 515 children examined, 402 (78.1%) were positive for at least one virus. Co-infections with two and three viruses were found in 64 (15.9%) of the infected children. Respiratory syncytial virus (RSV) was the predominant pathogen (37.5%), followed by rhinoviruses (13.8%), metapneumovirus (9.1%), adenoviruses (7%), bocaviruses (7%), influenza A(H1N1)pdm09 (4.9%), A(H3N2) (4.3%), type B (4.1%), and parainfluenza viruses 1/2/3 (2.9%). RSV-B were more prevalent than RSV-A during the three seasons. At least one respiratory virus was identified in 82.6% and 70.1% of the children with bronchiolitis and pneumonia, respectively. Respiratory viruses, especially RSV, are principal pathogens of ALRIs in children aged < 5 years. Diagnostic testing for respiratory viruses using molecular methods may lead to the reduced use of antibiotics and may assist in measures to control infection.
[h=4]KEYWORDS:[/h] Acute lower respiratory infections; Bronchiolitis; Pneumonia; Viral infection
PMID: 30637646 DOI: 10.1007/s42770-018-0033-2
[h=1]Viral pathogens associated with acute lower respiratory tract infections in children younger than 5 years of age in Bulgaria.[/h] Korsun N[SUP]1[/SUP], Angelova S[SUP]2[/SUP], Trifonova I[SUP]2[/SUP], Georgieva I[SUP]2[/SUP], Voleva S[SUP]2[/SUP], Tzotcheva I[SUP]3[/SUP], Mileva S[SUP]2,[/SUP][SUP]3[/SUP], Ivanov I[SUP]4[/SUP], Tcherveniakova T[SUP]4[/SUP], Perenovska P[SUP]3[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Acute lower respiratory infections (ALRIs) are a leading cause of morbidity and hospital admissions in children. This study aimed to determine the viral etiology of these infections in children aged < 5 years during three successive epidemic seasons in Bulgaria. Nasopharyngeal and throat specimens were collected from children with bronchiolitis and pneumonia during the 2015/2016, 2016/2017, and 2017/2018 seasons. The viral etiology was determined by individual real-time PCR assays against 11 respiratory viruses. Of the 515 children examined, 402 (78.1%) were positive for at least one virus. Co-infections with two and three viruses were found in 64 (15.9%) of the infected children. Respiratory syncytial virus (RSV) was the predominant pathogen (37.5%), followed by rhinoviruses (13.8%), metapneumovirus (9.1%), adenoviruses (7%), bocaviruses (7%), influenza A(H1N1)pdm09 (4.9%), A(H3N2) (4.3%), type B (4.1%), and parainfluenza viruses 1/2/3 (2.9%). RSV-B were more prevalent than RSV-A during the three seasons. At least one respiratory virus was identified in 82.6% and 70.1% of the children with bronchiolitis and pneumonia, respectively. Respiratory viruses, especially RSV, are principal pathogens of ALRIs in children aged < 5 years. Diagnostic testing for respiratory viruses using molecular methods may lead to the reduced use of antibiotics and may assist in measures to control infection.
[h=4]KEYWORDS:[/h] Acute lower respiratory infections; Bronchiolitis; Pneumonia; Viral infection
PMID: 30637646 DOI: 10.1007/s42770-018-0033-2