Giuseppe
Emeritus
[Source: Virology Journal, full text: (LINK). Abstract, edited.]
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A baculovirus dual expression system-based vaccine confers complete protection against lethal challenge with H9N2 avian inuenza virus in mice
Wenyao Lin, Huiying Fan, Xiaoliang Cheng, Yu Ye, Xiaowei Chen, Tao Ren, Wenbao Qi and Ming Liao
Virology Journal 2011, 8:273 doi:10.1186/1743-422X-8-273
Published: 4 June 2011
Abstract (provisional)
Background
Avian influenza viruses of H9N2 subtype have become highly prevalent in avian species. Although these viruses generally cause only mild to moderate disease, they can infect a wide variety of species, including chickens, quail, turkeys, ducks, geese, pheasant, partridge, and pigeon, even transmitted to mammalian species, including humans, accelerating the efforts to devise protective strategies against them.
Results
The results showed that stronger immune responses were induced in a mouse model immunized with BV-Dual-HA than in those vaccinated with a DNA vaccine encoding the same antigen. Moreover, complete protection against lethal challenge with H9N2 virus was observed in mice.
Conclusion
BV-Dual-HA could be utilized as a vaccine candidate against H9N2 virus infection.
- Wenyao Lin, Huiying Fan, Xiaoliang Cheng, Yu Ye, Xiaowei Chen, Tao Ren, Wenbao Qi and Ming Liao
Virology Journal 2011, 8:273 doi:10.1186/1743-422X-8-273
Published: 4 June 2011
Abstract (provisional)
Background
Avian influenza viruses of H9N2 subtype have become highly prevalent in avian species. Although these viruses generally cause only mild to moderate disease, they can infect a wide variety of species, including chickens, quail, turkeys, ducks, geese, pheasant, partridge, and pigeon, even transmitted to mammalian species, including humans, accelerating the efforts to devise protective strategies against them.
Results
The results showed that stronger immune responses were induced in a mouse model immunized with BV-Dual-HA than in those vaccinated with a DNA vaccine encoding the same antigen. Moreover, complete protection against lethal challenge with H9N2 virus was observed in mice.
Conclusion
BV-Dual-HA could be utilized as a vaccine candidate against H9N2 virus infection.
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