tetano
Editor, Senior Moderator
Virol J
. 2021 Jul 14;18(1):147.
doi: 10.1186/s12985-021-01615-y.
Clinical and virological course of patients with coronavirus disease 2019 in Jiangsu province, China: a retrospective, multi-center cohort study
Rui Huang[SUP] #[/SUP][SUP] 1 [/SUP], Li Zhu[SUP] #[/SUP][SUP] 2 [/SUP], Leyang Xue[SUP] #[/SUP][SUP] 3 [/SUP], Xuebing Yan[SUP] #[/SUP][SUP] 4 [/SUP], Jian Wang[SUP] #[/SUP][SUP] 1 [/SUP], Songping Huang[SUP] #[/SUP][SUP] 5 [/SUP], Biao Zhang[SUP] 6 [/SUP], Tianmin Xu[SUP] 7 [/SUP], Fang Ji[SUP] 4 [/SUP], Chunyang Li[SUP] 4 [/SUP], Fang Ming[SUP] 5 [/SUP], Yun Zhao[SUP] 8 [/SUP], Yang Li[SUP] 9 [/SUP], Juan Cheng[SUP] 10 [/SUP], Yinling Wang[SUP] 2 [/SUP], Huaping Shao[SUP] 11 [/SUP], Shuqin Hong[SUP] 12 [/SUP], Kang Chen[SUP] 13 [/SUP], Xiang-An Zhao[SUP] 14 [/SUP], Dawen Sang[SUP] 10 [/SUP], Lei Zou[SUP] 10 [/SUP], Haiyan Zhao[SUP] 11 [/SUP], Xinying Guan[SUP] 15 [/SUP], Xiaobing Chen[SUP] 16 [/SUP], Biyun Xu[SUP] 17 [/SUP], Juan Xia[SUP] 1 [/SUP], Yuxin Chen[SUP] 18 [/SUP], Xiaomin Yan[SUP] 1 [/SUP], Jie Wei[SUP] 19 [/SUP], Jiacheng Liu[SUP] 20 [/SUP], Longgen Liu[SUP] 21 [/SUP], Chuanwu Zhu[SUP] 22 [/SUP], Chao Wu[SUP] 23 [/SUP]
Affiliations
Abstract
Background: The clinical and virological course of patients with coronavirus disease 2019 (COVID-19) are lacking. We aimed to describe the clinical and virological characteristics of COVID-19 patients from 10 designated hospitals in 10 cities of Jiangsu province, China. The factors associated with the clearance of SARS-CoV-2 were investigated.
Methods: A total of 328 hospitalized patients with COVID-19 were retrospectively recruited. The epidemiological, clinical, laboratory, radiology and treatment data were collected. The associated factors of SARS-CoV-2 clearance were analyzed.
Results: The median duration of hospitalization was 16.0 days (interquartile range [IQR] 13.0-21.0 days). On multivariate Cox regression analysis, age > 60 years (hazard ratio
0.643, 95% confidence interval [CI] 0.454-0.911, P = 0.013) was associated with the delayed SARS-CoV-2 clearance, while the atomized inhalation of interferon α-2b could improve the clearance of SARS-CoV-2 (HR, 1.357, 95% CI 1.050-1.755, P = 0.020). Twenty-six (7.9%) patients developed respiratory failure and 4 (1.2%) patients developed ARDS. Twenty (6.1%) patients were admitted to the ICU, while no patient was deceased.
Conclusions: Our study found that age > 60 years was associated with the delayed SARS-CoV-2 clearance, while treated with atomized inhalation of interferon α-2b could promote the clearance of SARS-CoV-2.
Keywords: Clearance; Coronavirus disease 2019; SARS-CoV-2; Viral.
. 2021 Jul 14;18(1):147.
doi: 10.1186/s12985-021-01615-y.
Clinical and virological course of patients with coronavirus disease 2019 in Jiangsu province, China: a retrospective, multi-center cohort study
Rui Huang[SUP] #[/SUP][SUP] 1 [/SUP], Li Zhu[SUP] #[/SUP][SUP] 2 [/SUP], Leyang Xue[SUP] #[/SUP][SUP] 3 [/SUP], Xuebing Yan[SUP] #[/SUP][SUP] 4 [/SUP], Jian Wang[SUP] #[/SUP][SUP] 1 [/SUP], Songping Huang[SUP] #[/SUP][SUP] 5 [/SUP], Biao Zhang[SUP] 6 [/SUP], Tianmin Xu[SUP] 7 [/SUP], Fang Ji[SUP] 4 [/SUP], Chunyang Li[SUP] 4 [/SUP], Fang Ming[SUP] 5 [/SUP], Yun Zhao[SUP] 8 [/SUP], Yang Li[SUP] 9 [/SUP], Juan Cheng[SUP] 10 [/SUP], Yinling Wang[SUP] 2 [/SUP], Huaping Shao[SUP] 11 [/SUP], Shuqin Hong[SUP] 12 [/SUP], Kang Chen[SUP] 13 [/SUP], Xiang-An Zhao[SUP] 14 [/SUP], Dawen Sang[SUP] 10 [/SUP], Lei Zou[SUP] 10 [/SUP], Haiyan Zhao[SUP] 11 [/SUP], Xinying Guan[SUP] 15 [/SUP], Xiaobing Chen[SUP] 16 [/SUP], Biyun Xu[SUP] 17 [/SUP], Juan Xia[SUP] 1 [/SUP], Yuxin Chen[SUP] 18 [/SUP], Xiaomin Yan[SUP] 1 [/SUP], Jie Wei[SUP] 19 [/SUP], Jiacheng Liu[SUP] 20 [/SUP], Longgen Liu[SUP] 21 [/SUP], Chuanwu Zhu[SUP] 22 [/SUP], Chao Wu[SUP] 23 [/SUP]
Affiliations
- PMID: 34261488
- DOI: 10.1186/s12985-021-01615-y
Abstract
Background: The clinical and virological course of patients with coronavirus disease 2019 (COVID-19) are lacking. We aimed to describe the clinical and virological characteristics of COVID-19 patients from 10 designated hospitals in 10 cities of Jiangsu province, China. The factors associated with the clearance of SARS-CoV-2 were investigated.
Methods: A total of 328 hospitalized patients with COVID-19 were retrospectively recruited. The epidemiological, clinical, laboratory, radiology and treatment data were collected. The associated factors of SARS-CoV-2 clearance were analyzed.
Results: The median duration of hospitalization was 16.0 days (interquartile range [IQR] 13.0-21.0 days). On multivariate Cox regression analysis, age > 60 years (hazard ratio
0.643, 95% confidence interval [CI] 0.454-0.911, P = 0.013) was associated with the delayed SARS-CoV-2 clearance, while the atomized inhalation of interferon α-2b could improve the clearance of SARS-CoV-2 (HR, 1.357, 95% CI 1.050-1.755, P = 0.020). Twenty-six (7.9%) patients developed respiratory failure and 4 (1.2%) patients developed ARDS. Twenty (6.1%) patients were admitted to the ICU, while no patient was deceased.
Conclusions: Our study found that age > 60 years was associated with the delayed SARS-CoV-2 clearance, while treated with atomized inhalation of interferon α-2b could promote the clearance of SARS-CoV-2.
Keywords: Clearance; Coronavirus disease 2019; SARS-CoV-2; Viral.