tetano
Editor, Senior Moderator
Virol J
. 2023 Sep 8;20(1):209.
doi: 10.1186/s12985-023-02177-x. Clinical characteristics of abruptly increased paediatric patients with Omicron BF.7 or BA.5.2 in Beijing
Lei Yu[SUP] #[/SUP][SUP] 1 [/SUP], Congying Wang[SUP] #[/SUP][SUP] 2 [/SUP], Xiaoyun Li[SUP] #[/SUP][SUP] 3 [/SUP], Xinning Wang[SUP] 4 [/SUP], Yingying Kang[SUP] 2 [/SUP], Xiaomei Ma[SUP] 2 [/SUP], Rui Sun[SUP] 2 [/SUP], Yu Sun[SUP] 3 [/SUP], Runan Zhu[SUP] 3 [/SUP], Liping Jia[SUP] 3 [/SUP], Yao Yao[SUP] 3 [/SUP], Xiaohui Li[SUP] 2 [/SUP], Daitao Zhang[SUP] 5 [/SUP], Yang Pan[SUP] 5 [/SUP], Bing Lv[SUP] 5 [/SUP], Jing Yuan[SUP] 6 [/SUP], Linqing Zhao[SUP] 7 [/SUP], Qinglong Gu[SUP] 8 [/SUP], Jian Zhang[SUP] 9 [/SUP]
Affiliations
Background: The coronavirus disease 2019 outbreak has hit Beijing since mid-Nov, 2022, with soaring growth of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) among children. Therefore, it is vital to determine the clinical manifestations of epidemic SARS-CoV-2 strains in paediatric patients.
Methods: In this study, nucleic acid tests (NATs) for SARS-CoV-2 were performed in paediatric outpatients with symptoms of acute respiratory tract infection during 18 Nov-6 Dec, 2022. Half of the outpatients positive for SARS-CoV-2 were randomly selected to screen for other respiratory pathogens, whereas those with low cycle threshold values in SARS-CoV-2 NATs were amplified and sequenced to determine the SARS-CoV-2 variants. Finally, children positive for SARS-CoV-2 with clinical information in detail were enrolled in a follow-up study to identify potential factors significantly associated with long recovery.
Results: Among 9625 paediatric outpatients tested for nucleic acid of SARS-CoV-2, 733 (7.62%, 733/9625) were identified as SARS-CoV-2 NAT positive, with only three (0.82%, 3/366) co-infected with other pathogens among 366 randomly selected patients, and 71 (62.83%) determined as Omicron subvariant BF.7 and 42 (37.22%) as BA.5.2 among 113 successfully sequenced. Among the 681 patients with complete clinical information, fever was the most common symptom (96.8%). In a follow-up study of 592 patients, 46.96% became asymptomatic on the third day and 65.71% on the fifth day. Only 1.7% of infected children experienced febrile seizures. Combined with abnormal C-reactive protein, a higher percentage of antibiotics administration was observed. More co-living members and longer duration of first symptoms served as independent risk factors for long-term recovery, especially in children vaccinated for SARS-CoV-2.
Conclusions: BF.7 and BA.5.2 were the dominate Omicron subvariants and caused milder infections during the SARS-CoV-2 outbreak in Beijing. The number of co-living members and duration of first symptoms were independent risk factors for long-term recovery.
Keywords: Clinical characteristics; Omicron; Paediatric patients; Risk factors.
. 2023 Sep 8;20(1):209.
doi: 10.1186/s12985-023-02177-x. Clinical characteristics of abruptly increased paediatric patients with Omicron BF.7 or BA.5.2 in Beijing
Lei Yu[SUP] #[/SUP][SUP] 1 [/SUP], Congying Wang[SUP] #[/SUP][SUP] 2 [/SUP], Xiaoyun Li[SUP] #[/SUP][SUP] 3 [/SUP], Xinning Wang[SUP] 4 [/SUP], Yingying Kang[SUP] 2 [/SUP], Xiaomei Ma[SUP] 2 [/SUP], Rui Sun[SUP] 2 [/SUP], Yu Sun[SUP] 3 [/SUP], Runan Zhu[SUP] 3 [/SUP], Liping Jia[SUP] 3 [/SUP], Yao Yao[SUP] 3 [/SUP], Xiaohui Li[SUP] 2 [/SUP], Daitao Zhang[SUP] 5 [/SUP], Yang Pan[SUP] 5 [/SUP], Bing Lv[SUP] 5 [/SUP], Jing Yuan[SUP] 6 [/SUP], Linqing Zhao[SUP] 7 [/SUP], Qinglong Gu[SUP] 8 [/SUP], Jian Zhang[SUP] 9 [/SUP]
Affiliations
- PMID: 37684638
- DOI: 10.1186/s12985-023-02177-x
Background: The coronavirus disease 2019 outbreak has hit Beijing since mid-Nov, 2022, with soaring growth of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) among children. Therefore, it is vital to determine the clinical manifestations of epidemic SARS-CoV-2 strains in paediatric patients.
Methods: In this study, nucleic acid tests (NATs) for SARS-CoV-2 were performed in paediatric outpatients with symptoms of acute respiratory tract infection during 18 Nov-6 Dec, 2022. Half of the outpatients positive for SARS-CoV-2 were randomly selected to screen for other respiratory pathogens, whereas those with low cycle threshold values in SARS-CoV-2 NATs were amplified and sequenced to determine the SARS-CoV-2 variants. Finally, children positive for SARS-CoV-2 with clinical information in detail were enrolled in a follow-up study to identify potential factors significantly associated with long recovery.
Results: Among 9625 paediatric outpatients tested for nucleic acid of SARS-CoV-2, 733 (7.62%, 733/9625) were identified as SARS-CoV-2 NAT positive, with only three (0.82%, 3/366) co-infected with other pathogens among 366 randomly selected patients, and 71 (62.83%) determined as Omicron subvariant BF.7 and 42 (37.22%) as BA.5.2 among 113 successfully sequenced. Among the 681 patients with complete clinical information, fever was the most common symptom (96.8%). In a follow-up study of 592 patients, 46.96% became asymptomatic on the third day and 65.71% on the fifth day. Only 1.7% of infected children experienced febrile seizures. Combined with abnormal C-reactive protein, a higher percentage of antibiotics administration was observed. More co-living members and longer duration of first symptoms served as independent risk factors for long-term recovery, especially in children vaccinated for SARS-CoV-2.
Conclusions: BF.7 and BA.5.2 were the dominate Omicron subvariants and caused milder infections during the SARS-CoV-2 outbreak in Beijing. The number of co-living members and duration of first symptoms were independent risk factors for long-term recovery.
Keywords: Clinical characteristics; Omicron; Paediatric patients; Risk factors.