tetano
Editor, Senior Moderator
Virol J
. 2024 Nov 22;21(1):299.
doi: 10.1186/s12985-024-02531-7. Clinical outcomes of Omicron infection and vaccine acceptance among pediatric liver transplant recipients: insights from a cross-sectional survey
Zhigang Zheng[SUP] #[/SUP][SUP] 1 [/SUP], Yefeng Lu[SUP] #[/SUP][SUP] 2 [/SUP], Huimin Wu[SUP] #[/SUP][SUP] 2 [/SUP], Pui U Lam[SUP] 3 [/SUP], Xiaowei Sun[SUP] 4 [/SUP], Yanyan Song[SUP] 5 [/SUP], Hao Ji[SUP] 2 [/SUP], Yi Luo[SUP] 2 [/SUP], Tao Zhou[SUP] 2 [/SUP], Mingxuan Feng[SUP] 2 [/SUP], Ping Wan[SUP] 2 [/SUP], Jianjun Zhu[SUP] 2 [/SUP], Peiying Li[SUP] 6 [/SUP], Jun Deng[SUP] 7 [/SUP], Nan Shen[SUP] 8 [/SUP], Qing Cao[SUP] 8 [/SUP], Ji Liang[SUP] 9 10 [/SUP], Qiang Xia[SUP] 2 11 12 [/SUP], Feng Xue[SUP] 13 [/SUP]
Affiliations
Objectives: Our study aims to explore the clinical characteristics of Omicron infection in pediatric liver transplant recipients (PLTRs), after the national COVID-19 outbreak. Additionally, we will investigate changes in vaccine coverage and parental attitudes towards vaccinating their children after this current outbreak.
Methods: We conducted a web-based questionnaire survey to gather information on Omicron infection, vaccination status, and guardian attitude among PLTRs. Besides, utilized valid questionnaire and long-term follow-up information processing techniques, and performed statistical analysis of relevant parameters.
Results: 528 valid questionnaires were collected, among which, 251 responses replied Omicron infection status. The Omicron infection rate in Chinese PLTRs was 56.2% (141/251), similar to the report in the normal population (around 60%). 99.3% of infected PLTRs presented mild symptoms, mostly with fever (78.0%), followed by Cough (76.6%), with a mean RTPCR conversion time of 7 days; the overall PLTRs' vaccination rate in this study was 13.3%, similar to that of our previous study (9.4%). Besides, we found no significant differences of either infection rate or clinical symptoms between the vaccinated and unvaccinated groups. Moreover, the study showed 61.6% of guardians supported COVID-19 inoculation despite the outbreak of Omicron status.
Conclusions: The symptoms of Omicron infection in Chinese PLTRs were relatively mild, vaccine immunization had a limited effect on PLTRs' defense against Omicron infection, besides, their guardians supported the inoculation policy with a caution.
Clinical trial registration: http://www.chictr.org.cn , identifier ChiCTR2200055968.
Keywords: COVID-19; Nebulized inhalation vaccine; Omicron; Pediatric liver transplantation; Vaccine acceptance.
. 2024 Nov 22;21(1):299.
doi: 10.1186/s12985-024-02531-7. Clinical outcomes of Omicron infection and vaccine acceptance among pediatric liver transplant recipients: insights from a cross-sectional survey
Zhigang Zheng[SUP] #[/SUP][SUP] 1 [/SUP], Yefeng Lu[SUP] #[/SUP][SUP] 2 [/SUP], Huimin Wu[SUP] #[/SUP][SUP] 2 [/SUP], Pui U Lam[SUP] 3 [/SUP], Xiaowei Sun[SUP] 4 [/SUP], Yanyan Song[SUP] 5 [/SUP], Hao Ji[SUP] 2 [/SUP], Yi Luo[SUP] 2 [/SUP], Tao Zhou[SUP] 2 [/SUP], Mingxuan Feng[SUP] 2 [/SUP], Ping Wan[SUP] 2 [/SUP], Jianjun Zhu[SUP] 2 [/SUP], Peiying Li[SUP] 6 [/SUP], Jun Deng[SUP] 7 [/SUP], Nan Shen[SUP] 8 [/SUP], Qing Cao[SUP] 8 [/SUP], Ji Liang[SUP] 9 10 [/SUP], Qiang Xia[SUP] 2 11 12 [/SUP], Feng Xue[SUP] 13 [/SUP]
Affiliations
- PMID: 39578871
- PMCID: PMC11583437
- DOI: 10.1186/s12985-024-02531-7
Objectives: Our study aims to explore the clinical characteristics of Omicron infection in pediatric liver transplant recipients (PLTRs), after the national COVID-19 outbreak. Additionally, we will investigate changes in vaccine coverage and parental attitudes towards vaccinating their children after this current outbreak.
Methods: We conducted a web-based questionnaire survey to gather information on Omicron infection, vaccination status, and guardian attitude among PLTRs. Besides, utilized valid questionnaire and long-term follow-up information processing techniques, and performed statistical analysis of relevant parameters.
Results: 528 valid questionnaires were collected, among which, 251 responses replied Omicron infection status. The Omicron infection rate in Chinese PLTRs was 56.2% (141/251), similar to the report in the normal population (around 60%). 99.3% of infected PLTRs presented mild symptoms, mostly with fever (78.0%), followed by Cough (76.6%), with a mean RTPCR conversion time of 7 days; the overall PLTRs' vaccination rate in this study was 13.3%, similar to that of our previous study (9.4%). Besides, we found no significant differences of either infection rate or clinical symptoms between the vaccinated and unvaccinated groups. Moreover, the study showed 61.6% of guardians supported COVID-19 inoculation despite the outbreak of Omicron status.
Conclusions: The symptoms of Omicron infection in Chinese PLTRs were relatively mild, vaccine immunization had a limited effect on PLTRs' defense against Omicron infection, besides, their guardians supported the inoculation policy with a caution.
Clinical trial registration: http://www.chictr.org.cn , identifier ChiCTR2200055968.
Keywords: COVID-19; Nebulized inhalation vaccine; Omicron; Pediatric liver transplantation; Vaccine acceptance.