tetano
Editor, Senior Moderator
Virol J
. 2022 Jun 8;19(1):101.
doi: 10.1186/s12985-022-01828-9.
Herpesvirus and neurological manifestations in patients with severe coronavirus disease
Vanessa Cristine de Souza Carneiro[SUP] 1 2 [/SUP], Soniza Vieira Alves-Leon[SUP] 3 4 [/SUP], Dmitry José de Santana Sarmento[SUP] 5 [/SUP], Wagner Luis da Costa Nunes Pimentel Coelho[SUP] 2 [/SUP], Otacilio da Cruz Moreira[SUP] 1 6 [/SUP], Andreza Lemos Salvio[SUP] 4 [/SUP], Carlos Henrique Ferreira Ramos[SUP] 4 [/SUP], Carlos Henrique Ferreira Ramos Filho[SUP] 4 [/SUP], Carla Augusta Barreto Marques[SUP] 4 [/SUP], João Paulo da Costa Gonçalves[SUP] 3 4 [/SUP], Luciane Almeida Amado Leon[SUP] 2 [/SUP], Vanessa Salete de Paula[SUP] 7 8 [/SUP]
Affiliations
Abstract
Background: Certain clinical manifestations of coronavirus disease (COVID-19) mimic those associated with human herpesvirus (HHV) infection. In this study, we estimated the prevalence of herpesvirus in patients with COVID-19 and determined if coinfection is associated with poorer outcomes and neurological symptoms.
Methods: We analyzed samples of 53 patients diagnosed with COVID-19. The samples were evaluated for the presence of alphaherpesviruses, betaherpesviruses, and gammaherpesviruses, and the viral loads were quantified using quantitative polymerase chain reaction (qPCR) method.
Results: Among the patients, in 79.2% had detection at least one type of herpesvirus. HHV-6 (47.2%), cytomegalovirus (43.3%), and HHV-7 (39.6%) showed the highest detection rates. Patients with a high severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) load were more likely to show herpes simplex virus 1 detection (p = 0.037). Among patients coinfected with SARS-CoV-2 and HHVs, 26.4% showed central nervous system-associated neurological symptoms and herpetic manifestations. A statistically significant association was observed between neurological changes and HHV-6 detection (p = 0.034).
Conclusions: The findings showed a high prevalence of herpesvirus in patients with COVID-19. Furthermore, even though SARS-CoV-2 and HHV coinfection was not associated with poorer outcomes, the findings demonstrated the association between neurological symptoms and HHV-6 detection.
Keywords: Herpesvirus; Neurological manifestations; SARS-CoV-2 infection.
. 2022 Jun 8;19(1):101.
doi: 10.1186/s12985-022-01828-9.
Herpesvirus and neurological manifestations in patients with severe coronavirus disease
Vanessa Cristine de Souza Carneiro[SUP] 1 2 [/SUP], Soniza Vieira Alves-Leon[SUP] 3 4 [/SUP], Dmitry José de Santana Sarmento[SUP] 5 [/SUP], Wagner Luis da Costa Nunes Pimentel Coelho[SUP] 2 [/SUP], Otacilio da Cruz Moreira[SUP] 1 6 [/SUP], Andreza Lemos Salvio[SUP] 4 [/SUP], Carlos Henrique Ferreira Ramos[SUP] 4 [/SUP], Carlos Henrique Ferreira Ramos Filho[SUP] 4 [/SUP], Carla Augusta Barreto Marques[SUP] 4 [/SUP], João Paulo da Costa Gonçalves[SUP] 3 4 [/SUP], Luciane Almeida Amado Leon[SUP] 2 [/SUP], Vanessa Salete de Paula[SUP] 7 8 [/SUP]
Affiliations
- PMID: 35676707
- DOI: 10.1186/s12985-022-01828-9
Abstract
Background: Certain clinical manifestations of coronavirus disease (COVID-19) mimic those associated with human herpesvirus (HHV) infection. In this study, we estimated the prevalence of herpesvirus in patients with COVID-19 and determined if coinfection is associated with poorer outcomes and neurological symptoms.
Methods: We analyzed samples of 53 patients diagnosed with COVID-19. The samples were evaluated for the presence of alphaherpesviruses, betaherpesviruses, and gammaherpesviruses, and the viral loads were quantified using quantitative polymerase chain reaction (qPCR) method.
Results: Among the patients, in 79.2% had detection at least one type of herpesvirus. HHV-6 (47.2%), cytomegalovirus (43.3%), and HHV-7 (39.6%) showed the highest detection rates. Patients with a high severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) load were more likely to show herpes simplex virus 1 detection (p = 0.037). Among patients coinfected with SARS-CoV-2 and HHVs, 26.4% showed central nervous system-associated neurological symptoms and herpetic manifestations. A statistically significant association was observed between neurological changes and HHV-6 detection (p = 0.034).
Conclusions: The findings showed a high prevalence of herpesvirus in patients with COVID-19. Furthermore, even though SARS-CoV-2 and HHV coinfection was not associated with poorer outcomes, the findings demonstrated the association between neurological symptoms and HHV-6 detection.
Keywords: Herpesvirus; Neurological manifestations; SARS-CoV-2 infection.