tetano
Editor, Senior Moderator
Virol J
. 2021 Sep 8;18(1):182.
doi: 10.1186/s12985-021-01651-8.
In vitro efficacy of Artemisia extracts against SARS-CoV-2
Chuanxiong Nie[SUP] 1 2 [/SUP], Jakob Trimpert[SUP] 1 [/SUP], Sooyeon Moon[SUP] 3 [/SUP], Rainer Haag[SUP] 2 [/SUP], Kerry Gilmore[SUP] 3 4 [/SUP], Benedikt B Kaufer[SUP] 5 [/SUP], Peter H Seeberger[SUP] 2 3 [/SUP]
Affiliations
Abstract
Background: Traditional medicines based on herbal extracts have been proposed as affordable treatments for patients suffering from coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Teas and drinks containing extracts of Artemisia annua and Artemisia afra have been widely used in Africa in efforts to prevent SARS-CoV-2 infection and fight COVID-19.
Methods: The plant extracts and Covid-Organics drink produced in Madagascar were tested for plaque reduction using both feline coronavirus and SARS-CoV-2 in vitro. Their cytotoxicities were also investigated.
Results: Several extracts as well as Covid-Organics inhibited SARS-CoV-2 and FCoV infection at concentrations that did not affect cell viability.
Conclusions: Some plant extracts show inhibitory activity against FCoV and SARS-CoV-2. However, it remains unclear whether peak plasma concentrations in humans can reach levels needed to inhibit viral infection following consumption of teas or Covid-Organics. Clinical studies are required to evaluate the utility of these drinks for COVID-19 prevention or treatment of patients.
Keywords: Antivirals; Artemisia afra; Artemisia annua; COVID-19; Covid-organics; Feline coronavirus (FCoV); SARS-CoV-2.
. 2021 Sep 8;18(1):182.
doi: 10.1186/s12985-021-01651-8.
In vitro efficacy of Artemisia extracts against SARS-CoV-2
Chuanxiong Nie[SUP] 1 2 [/SUP], Jakob Trimpert[SUP] 1 [/SUP], Sooyeon Moon[SUP] 3 [/SUP], Rainer Haag[SUP] 2 [/SUP], Kerry Gilmore[SUP] 3 4 [/SUP], Benedikt B Kaufer[SUP] 5 [/SUP], Peter H Seeberger[SUP] 2 3 [/SUP]
Affiliations
- PMID: 34496903
- DOI: 10.1186/s12985-021-01651-8
Abstract
Background: Traditional medicines based on herbal extracts have been proposed as affordable treatments for patients suffering from coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Teas and drinks containing extracts of Artemisia annua and Artemisia afra have been widely used in Africa in efforts to prevent SARS-CoV-2 infection and fight COVID-19.
Methods: The plant extracts and Covid-Organics drink produced in Madagascar were tested for plaque reduction using both feline coronavirus and SARS-CoV-2 in vitro. Their cytotoxicities were also investigated.
Results: Several extracts as well as Covid-Organics inhibited SARS-CoV-2 and FCoV infection at concentrations that did not affect cell viability.
Conclusions: Some plant extracts show inhibitory activity against FCoV and SARS-CoV-2. However, it remains unclear whether peak plasma concentrations in humans can reach levels needed to inhibit viral infection following consumption of teas or Covid-Organics. Clinical studies are required to evaluate the utility of these drinks for COVID-19 prevention or treatment of patients.
Keywords: Antivirals; Artemisia afra; Artemisia annua; COVID-19; Covid-organics; Feline coronavirus (FCoV); SARS-CoV-2.