tetano
Editor, Senior Moderator
Virol J
. 2023 Aug 2;20(1):169.
doi: 10.1186/s12985-023-02116-w. Neutrophils in COVID-19: recent insights and advances
Jiayu Li[SUP] 1 [/SUP], Kegong Zhang[SUP] 1 [/SUP], Ye Zhang[SUP] 1 [/SUP], Ziyang Gu[SUP] 1 [/SUP], Changxing Huang[SUP] 2 [/SUP]
Affiliations
Coronavirus disease 2019 (COVID-19) is an acute respiratory disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which can lead to acute respiratory distress syndrome (ARDS), multi-organ failure and death, posing significant threat to human health. Studies have found that pathological mechanisms, such as cytokine storms caused by uncontrolled innate immune system activation, release of damage-associated molecular patterns during tissue injury and a high incidence of thrombotic events, are associated with the function and dysfunction of neutrophils. Specifically, the increased formation of low-density neutrophils (LDNs) and neutrophil extracellular traps (NETs) has been shown to be closely linked with the severity and poor prognosis in patients with COVID-19. Our work focuses on understanding the increased number, abnormal activation, lung tissue infiltration, and elevated neutrophil-to-lymphocyte ratio in the pathogenesis of COVID-19. We also explore the involvement of NETs and LDNs in disease progression and thrombosis formation, along with potential therapeutic strategies targeting neutrophil and NETs formation.
Keywords: COVID-19; Cytokine storm; Low- density neutrophils (LDNs); Neutrophil extracellular traps (NETs); Neutrophils; Thrombosis; Treatment strategies.
. 2023 Aug 2;20(1):169.
doi: 10.1186/s12985-023-02116-w. Neutrophils in COVID-19: recent insights and advances
Jiayu Li[SUP] 1 [/SUP], Kegong Zhang[SUP] 1 [/SUP], Ye Zhang[SUP] 1 [/SUP], Ziyang Gu[SUP] 1 [/SUP], Changxing Huang[SUP] 2 [/SUP]
Affiliations
- PMID: 37533131
- DOI: 10.1186/s12985-023-02116-w
Coronavirus disease 2019 (COVID-19) is an acute respiratory disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which can lead to acute respiratory distress syndrome (ARDS), multi-organ failure and death, posing significant threat to human health. Studies have found that pathological mechanisms, such as cytokine storms caused by uncontrolled innate immune system activation, release of damage-associated molecular patterns during tissue injury and a high incidence of thrombotic events, are associated with the function and dysfunction of neutrophils. Specifically, the increased formation of low-density neutrophils (LDNs) and neutrophil extracellular traps (NETs) has been shown to be closely linked with the severity and poor prognosis in patients with COVID-19. Our work focuses on understanding the increased number, abnormal activation, lung tissue infiltration, and elevated neutrophil-to-lymphocyte ratio in the pathogenesis of COVID-19. We also explore the involvement of NETs and LDNs in disease progression and thrombosis formation, along with potential therapeutic strategies targeting neutrophil and NETs formation.
Keywords: COVID-19; Cytokine storm; Low- density neutrophils (LDNs); Neutrophil extracellular traps (NETs); Neutrophils; Thrombosis; Treatment strategies.