tetano
Editor, Senior Moderator
Virol J
. 2023 May 5;20(1):88.
doi: 10.1186/s12985-023-02046-7. Systematic levels of IL-29 and microRNA185-5p were not associated with severe COVID-19 in the Iranian population
Omidreza Sarrafi[SUP] 1 [/SUP], Ashraf Kariminik[SUP] 2 [/SUP], Mohammad Kazemi Arababadi[SUP] 3 4 [/SUP]
Affiliations
Background: Increased systematic pro-inflammatory cytokines is the main cause of the inflammatory conditions of the hospitalized severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infected patients. In this project, serum levels of IL-29 and whole blood levels of microRNA-185-5p (miR-185-5p) were evaluated in the hospitalized SARS-CoV-2 infected patients.
Methods: This project was performed on the 60 hospitalized SARS-CoV-2 infected patients and 60 healthy controls to evaluate IL-29 and miR185-5p expression levels. IL-29 expression was explored using enzyme linked immunoassay (ELISA), while miR185-5p was evaluated using Real-Time PCR techniques.
Results: The results demonstrated that neither IL-29 serum levels nor relative expressions of miR-185-5p were significantly different between patients and healthy controls.
Conclusion: Due to the results that are presented here, systematic levels of IL-29 and miR-185-5p cannot be considered as the main risk factors for induction of inflammation in the hospitalized SARS-CoV-2 infected patients.
Keywords: COVID-19; IL-29; microRNA185-5p.
. 2023 May 5;20(1):88.
doi: 10.1186/s12985-023-02046-7. Systematic levels of IL-29 and microRNA185-5p were not associated with severe COVID-19 in the Iranian population
Omidreza Sarrafi[SUP] 1 [/SUP], Ashraf Kariminik[SUP] 2 [/SUP], Mohammad Kazemi Arababadi[SUP] 3 4 [/SUP]
Affiliations
- PMID: 37147714
- DOI: 10.1186/s12985-023-02046-7
Background: Increased systematic pro-inflammatory cytokines is the main cause of the inflammatory conditions of the hospitalized severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infected patients. In this project, serum levels of IL-29 and whole blood levels of microRNA-185-5p (miR-185-5p) were evaluated in the hospitalized SARS-CoV-2 infected patients.
Methods: This project was performed on the 60 hospitalized SARS-CoV-2 infected patients and 60 healthy controls to evaluate IL-29 and miR185-5p expression levels. IL-29 expression was explored using enzyme linked immunoassay (ELISA), while miR185-5p was evaluated using Real-Time PCR techniques.
Results: The results demonstrated that neither IL-29 serum levels nor relative expressions of miR-185-5p were significantly different between patients and healthy controls.
Conclusion: Due to the results that are presented here, systematic levels of IL-29 and miR-185-5p cannot be considered as the main risk factors for induction of inflammation in the hospitalized SARS-CoV-2 infected patients.
Keywords: COVID-19; IL-29; microRNA185-5p.